PMID- 26381094
OWN - NLM
STAT- MEDLINE
DCOM- 20160712
LR  - 20220331
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 29
IP  - 12
DP  - 2015 Dec
TI  - Optical coherence tomographic angiography shows reduced deep capillary flow in 
      paracentral acute middle maculopathy.
PG  - 1620-4
LID - 10.1038/eye.2015.180 [doi]
AB  - INTRODUCTION: Paracentral acute middle maculopathy (PAMM) has been described as 
      an ischemic lesion of the middle retinal layers with a characteristic lamellar 
      hyper-reflective placoid appearance in the acute phase and thinning of the 
      involved retinal layers in the chronic phase. Optical coherence tomographic 
      angiography (OCTA) is a novel and non-invasive technique for imaging retinal 
      capillary vasculature with en face segmentation capabilities. METHOD: Case 
      series. We describe two patients with PAMM who underwent clinical examination and 
      multimodal imaging including OCTA. RESULTS: In the first patient, who presented 
      with PAMM secondary to acute cilioretinal artery occlusion, OCTA demonstrated 
      reduction in flow in the deep capillary plexus (DCP). One month later, OCTA 
      revealed a flow void due to thinning of the GCL, INL, and OPL and paradoxical 
      apparent ONL thickening. Similar findings of focal retinal lamellar ectopia were 
      seen in the second patient, who had an incidentally detected chronic PAMM lesion. 
      CONCLUSIONS: OCTA images the superficial and deep capillary plexi independently. 
      PAMM is characterized by acute and chronic attenuation of the DCP flow signature. 
      Focal lamellar ectopia in PAMM is discussed.
FAU - Dansingani, K K
AU  - Dansingani KK
AD  - Vitreous Retina Macula Consultants of New York, New York, New York, USA.
AD  - LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat 
      Hospital, New York, New York, USA.
AD  - Moorfields Eye Hospital, London, UK.
FAU - Inoue, M
AU  - Inoue M
AD  - Vitreous Retina Macula Consultants of New York, New York, New York, USA.
AD  - LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat 
      Hospital, New York, New York, USA.
FAU - Engelbert, M
AU  - Engelbert M
AD  - Vitreous Retina Macula Consultants of New York, New York, New York, USA.
AD  - LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat 
      Hospital, New York, New York, USA.
AD  - Department of Ophthalmology, New York University School of Medicine, New York, 
      New York, USA.
FAU - Freund, K B
AU  - Freund KB
AD  - Vitreous Retina Macula Consultants of New York, New York, New York, USA.
AD  - LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat 
      Hospital, New York, New York, USA.
AD  - Department of Ophthalmology, New York University School of Medicine, New York, 
      New York, USA.
AD  - Department of Ophthalmology, North-Shore Long Island Jewish Health System, 
      Manhasset, New York, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150918
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
CIN - Eye (Lond). 2016 May;30(5):643-4. PMID: 26915742
MH  - Aged
MH  - Blood Flow Velocity
MH  - Capillaries/pathology
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multimodal Imaging
MH  - Retinal Artery Occlusion/physiopathology
MH  - Retinal Diseases/*diagnosis/*physiopathology
MH  - Retinal Neurons
MH  - Retinal Vessels/*pathology
MH  - Tomography, Optical Coherence/methods
PMC - PMC5129811
COIS- KBF is a consultant for the following companies: Genentech, Optos, ThromboGenics, 
      Ohr Pharmaceutical, Bayer HealthCare and Heidelberg Engineering. ME was former 
      consultant for Bayer and Genentech.
EDAT- 2015/09/19 06:00
MHDA- 2016/07/13 06:00
PMCR- 2016/12/01
CRDT- 2015/09/19 06:00
PHST- 2015/04/15 00:00 [received]
PHST- 2015/07/12 00:00 [accepted]
PHST- 2015/09/19 06:00 [entrez]
PHST- 2015/09/19 06:00 [pubmed]
PHST- 2016/07/13 06:00 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - eye2015180 [pii]
AID - 10.1038/eye.2015.180 [doi]
PST - ppublish
SO  - Eye (Lond). 2015 Dec;29(12):1620-4. doi: 10.1038/eye.2015.180. Epub 2015 Sep 18.