PMID- 26381432
OWN - NLM
STAT- MEDLINE
DCOM- 20160407
LR  - 20221207
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 62
DP  - 2016 Jan-Feb
TI  - The prevalence of mild cognitive impairment with type 2 diabetes mellitus among 
      elderly people in China: A cross-sectional study.
PG  - 138-42
LID - S0167-4943(15)30055-8 [pii]
LID - 10.1016/j.archger.2015.09.003 [doi]
AB  - BACKGROUND: In absence of curative treatments for dementia with type 2 diabetes 
      mellitus (T2DM), mild cognitive impairment (MCI) in T2DM, the preclinical 
      transitional states of dementia with T2DM has attracted dramatic attention. Our 
      study was to estimate the prevalence and distribution of MCI in T2DM subjects 
      from China, and identify influencing factors of subjects in MCI with T2DM. 
      METHODS: In the present study, we performed cluster random sampling of 8213 
      people aged 65 years and older in Tianjin, a metropolitan city, located in 
      northern China. All participants were interviewed and screened for T2DM. 1109 
      subjects with T2DM were initially screened with American Diabetes Association 
      criteria for diagnosis of diabetes mellitus and were diagnosed with MCI and 
      dementia according to the criteria of DSM-IIIR. The prevalence of MCI and 
      dementia in subjects with T2DM were compared with that in ordinary subjects. 
      Logistic regression analyses were performed to evaluate risk of MCI with T2DM. 
      RESULTS: Among all 8213 subjects, overall MCI and dementia with T2DM prevalence 
      were 13.5% and 2.34%, respectively. Compared with ordinary subjects, the 
      prevalence of MCI in the present study was more frequent than the prevalence of 
      MCI for the general population in almost each age group. In the univariate 
      analyses, among all diabetic subjects, compared with cognitive intactly subjects, 
      MCI subjects had significantly higher levels of age, current smoking, mean waist 
      circumference, duration from onset of diabetes, insulin intake, systolic BP, 
      fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and immunoreactive 
      insulin (IRI). In multivariate logistic regression analyses, variables including 
      current smoking, duration from onset of diabetes, FPG, HbA1c and IRI were 
      significantly associated with increased risk for MCI with T2DM, the ORs were 
      1.36,1.33,1.17,1.25 and 1.33, respectively (all P<0.05). CONCLUSIONS: The present 
      study confirms the high prevalence of MCI with T2DM among the elderly population 
      of China. T2DM is related to a higher risk of MCI in a population with a high 
      prevalence of this disorder and may aggravate the clinical picture as a 
      concomitant factor.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Gao, Yuxia
AU  - Gao Y
AD  - Department of Cardiology, General Hospital of Tianjin Medical University, Tianjin 
      300052, China.
FAU - Xiao, Yanyu
AU  - Xiao Y
AD  - Department of Nutrition and Food Science, School of Public Health, Tianjin 
      Medical University, Tianjin 30070, China.
FAU - Miao, Rujuan
AU  - Miao R
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin 300070, China.
FAU - Zhao, Jiangang
AU  - Zhao J
AD  - Community Health Service Center, Sanhuailu Street, Binhai New District, Tianjin 
      300450, China.
FAU - Cui, Mingfei
AU  - Cui M
AD  - Community Health Service Center, Sanhuailu Street, Binhai New District, Tianjin 
      300450, China.
FAU - Huang, Guowei
AU  - Huang G
AD  - Department of Nutrition and Food Science, School of Public Health, Tianjin 
      Medical University, Tianjin 30070, China. Electronic address: 
      huangguowei@tmu.edu.cn.
FAU - Fei, Ma
AU  - Fei M
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tianjin 
      Medical University, Tianjin 300070, China. Electronic address: 
      mf2002245mf@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150910
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 0 (Insulin)
SB  - IM
MH  - Aged
MH  - Asian People
MH  - China/epidemiology
MH  - Cognitive Dysfunction/*epidemiology/ethnology
MH  - Cross-Sectional Studies
MH  - Dementia/*epidemiology/ethnology
MH  - Diabetes Mellitus, Type 2/*epidemiology/ethnology
MH  - Female
MH  - Geriatric Assessment
MH  - Humans
MH  - Insulin
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prevalence
MH  - Risk Factors
MH  - Urban Population
OTO - NOTNLM
OT  - Cross-sectional study
OT  - Dementia
OT  - Mild cognitive impairment
OT  - Prevalence
OT  - Type 2 diabetes mellitus
EDAT- 2015/09/19 06:00
MHDA- 2016/04/08 06:00
CRDT- 2015/09/19 06:00
PHST- 2015/07/03 00:00 [received]
PHST- 2015/09/01 00:00 [revised]
PHST- 2015/09/08 00:00 [accepted]
PHST- 2015/09/19 06:00 [entrez]
PHST- 2015/09/19 06:00 [pubmed]
PHST- 2016/04/08 06:00 [medline]
AID - S0167-4943(15)30055-8 [pii]
AID - 10.1016/j.archger.2015.09.003 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2016 Jan-Feb;62:138-42. doi: 
      10.1016/j.archger.2015.09.003. Epub 2015 Sep 10.