PMID- 26381876
OWN - NLM
STAT- MEDLINE
DCOM- 20161222
LR  - 20221207
IS  - 1878-7533 (Electronic)
IS  - 1550-7289 (Linking)
VI  - 12
IP  - 2
DP  - 2016 Feb
TI  - The long-term impact of biliopancreatic diversion on glycemic control in the 
      severely obese with type 2 diabetes mellitus in relation to preoperative duration 
      of diabetes.
PG  - 345-9
LID - S1550-7289(15)00155-0 [pii]
LID - 10.1016/j.soard.2015.05.012 [doi]
AB  - BACKGROUND: Bariatric surgery has been shown to be effective in severely obese 
      patients with type 2 diabetes mellitus (T2DM). OBJECTIVE: Evaluate the long-term 
      efficacy of biliopancreatic diversion (BPD) for the treatment of T2DM depending 
      on the preoperative duration of T2DM. SETTING: University Hospital. METHODS: 
      Retrospective analysis investigating 2 subsets of severely obese patients who had 
      undergone BPD from 1984 to 1995. The first included 52 patients with a 
      preoperative T2DM duration of ~1 year (SD group - 49 on oral agents and 3 on 
      insulin), and the second included 68 patients who had been diabetic for>5 years 
      before BPD (LD group - 52 on oral agents and 16 on insulin). Postoperatively, 
      T2DM was regarded as in remission when fasting serum glucose (FSG) was lower than 
      100 mg/dL on regular diet and without antidiabetic therapy. RESULTS: In the SD 
      patients, the number of individuals without T2DM remission were lower both at 
      5-10 (0/31, 0% of patients, versus 8/54, 15% of patients, p<.04) and at>15 years 
      (1/28, 3% of patients, versus 10/41, 24% of patients, p<.0012). Furthermore, 
      after BPD, the number of patients with dyslipidemia strongly reduced (p<.001) in 
      both groups, values at 5-10 years remaining very similar to those observed at>15 
      years. CONCLUSION: These results indicate that severely obese patients with 
      longer T2DM duration have a worse metabolic outcome maintained at long and very 
      long term following BPD.
CI  - Copyright (c) 2016. Published by Elsevier Inc.
FAU - Camerini, Giovanni B
AU  - Camerini GB
AD  - Department of Surgery, University of Genova, Azienda Ospedale-Universita San 
      Martino, Genova, Italy.
FAU - Papadia, Francesco S
AU  - Papadia FS
AD  - Department of Surgery, University of Genova, Azienda Ospedale-Universita San 
      Martino, Genova, Italy.
FAU - Carlini, Flavia
AU  - Carlini F
AD  - Department of Surgery, University of Genova, Azienda Ospedale-Universita San 
      Martino, Genova, Italy.
FAU - Catalano, Mariafrancesca
AU  - Catalano M
AD  - Department of Surgery, University of Genova, Azienda Ospedale-Universita San 
      Martino, Genova, Italy.
FAU - Adami, Gian Franco
AU  - Adami GF
AD  - Department of Surgery, University of Genova, Azienda Ospedale-Universita San 
      Martino, Genova, Italy. Electronic address: adami@unige.it.
FAU - Scopinaro, Nicola
AU  - Scopinaro N
AD  - Department of Surgery, University of Genova, Azienda Ospedale-Universita San 
      Martino, Genova, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150528
PL  - United States
TA  - Surg Obes Relat Dis
JT  - Surgery for obesity and related diseases : official journal of the American 
      Society for Bariatric Surgery
JID - 101233161
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Biliopancreatic Diversion/*methods
MH  - Blood Glucose/*metabolism
MH  - Blood Glucose Self-Monitoring/*methods
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Insulin/*blood
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/blood/complications/*surgery
MH  - Preoperative Period
MH  - Prognosis
MH  - Retrospective Studies
MH  - Time Factors
MH  - Weight Loss
OTO - NOTNLM
OT  - Bariatric surgery
OT  - Biliopancreatic diversion
OT  - Diabetes resolution
OT  - Retrospective study
OT  - Type 2 diabetes
OT  - Very long term results
EDAT- 2015/09/19 06:00
MHDA- 2016/12/23 06:00
CRDT- 2015/09/19 06:00
PHST- 2015/02/24 00:00 [received]
PHST- 2015/05/21 00:00 [revised]
PHST- 2015/05/22 00:00 [accepted]
PHST- 2015/09/19 06:00 [entrez]
PHST- 2015/09/19 06:00 [pubmed]
PHST- 2016/12/23 06:00 [medline]
AID - S1550-7289(15)00155-0 [pii]
AID - 10.1016/j.soard.2015.05.012 [doi]
PST - ppublish
SO  - Surg Obes Relat Dis. 2016 Feb;12(2):345-9. doi: 10.1016/j.soard.2015.05.012. Epub 
      2015 May 28.