PMID- 26382215 OWN - NLM STAT- MEDLINE DCOM- 20160629 LR - 20181113 IS - 1475-2840 (Electronic) IS - 1475-2840 (Linking) VI - 14 DP - 2015 Sep 18 TI - Altered myocardial response in patients with diabetic retinopathy: an exercise echocardiography study. PG - 123 LID - 10.1186/s12933-015-0281-5 [doi] LID - 123 AB - BACKGROUND: Type 2 diabetes mellitus (T2DM) complicated by retinopathy is associated with altered left ventricular (LV) structure and resting myocardial dysfunction unlike T2DM without retinopathy. The myocardial response to stress has not been compared in patients with and without diabetic retinopathy. The aim of this retrospective study was to determine the relationship between retinopathy and myocardial function in patients with T2DM at rest and during exercise echocardiography. METHODS: 134 patients with T2DM and no evidence of underlying coronary artery disease were recruited. All patients underwent retinal photography to screen for diabetic retinopathy, and resting and exercise echocardiography. Resting echocardiography was analyzed by conventional echocardiographic parameters and speckle tracking derived global longitudinal strain (GLS). Exercise echocardiography parameters included diastolic function reserve index (DFRI) and stress GLS. RESULTS: The mean age of participants was 60 years and 49% were male. Diabetic retinopathy was identified in 43 patients (32%). Resting echocardiography revealed that those with diabetic retinopathy had a higher prevalence of impaired diastolic function, higher E/E' ratio (LV filling pressures) and impaired resting GLS compared with those without. Exercise echocardiography revealed that those with diabetic retinopathy also had more impaired DFRI and stress GLS. Multivariable analysis showed that the presence of diabetic retinopathy was independently associated with high resting E/E', diastolic dysfunction grade, impaired resting GLS, low DFRI and impaired stress GLS. CONCLUSIONS: In conclusion, the presence of diabetic retinopathy was independently associated with impaired resting myocardial function (diastolic and systolic function) and myocardial function during stress (evaluated by DFRI and stress GLS). FAU - Zhen, Zhe AU - Zhen Z AD - Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Rm 1929b, Block K, Hong Kong, China. zhenzhe717@gmail.com. FAU - Chen, Yan AU - Chen Y AD - Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Rm 1929b, Block K, Hong Kong, China. 290505880@qq.com. FAU - Shih, Kendrick AU - Shih K AD - Department of Ophthalmology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China. kendrick.shih@gmail.com. FAU - Liu, Ju-Hua AU - Liu JH AD - Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Rm 1929b, Block K, Hong Kong, China. juhualiu1984@163.com. FAU - Yuen, Michele AU - Yuen M AD - Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. micheleyuen@hotmail.com. FAU - Wong, David Sai-Hung AU - Wong DS AD - Department of Ophthalmology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China. shdwong@hku.hk. FAU - Lam, Karen Siu-Ling AU - Lam KS AD - Division of Endocrinology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China. ksllam@hku.hk. AD - Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. ksllam@hku.hk. FAU - Tse, Hung-Fat AU - Tse HF AD - Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Rm 1929b, Block K, Hong Kong, China. hftse@hkucc.hku.hk. AD - Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. hftse@hkucc.hku.hk. FAU - Yiu, Kai-Hang AU - Yiu KH AD - Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Rm 1929b, Block K, Hong Kong, China. khkyiu@hku.hk. AD - Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. khkyiu@hku.hk. AD - Department of Medicine, The University of Hong Kong ShenZhen Hospital, Shenzhen, China. khkyiu@hku.hk. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150918 PL - England TA - Cardiovasc Diabetol JT - Cardiovascular diabetology JID - 101147637 SB - IM MH - Aged MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/*complications/diagnosis MH - Diabetic Cardiomyopathies/*diagnostic imaging/etiology/physiopathology MH - Diabetic Retinopathy/diagnosis/*etiology MH - *Echocardiography, Doppler, Pulsed MH - Echocardiography, Stress/*methods MH - *Exercise Test MH - Female MH - Humans MH - Male MH - Middle Aged MH - Multivariate Analysis MH - Predictive Value of Tests MH - Prognosis MH - Retrospective Studies MH - Risk Assessment MH - Risk Factors MH - Stroke Volume MH - Ventricular Dysfunction, Left/*diagnostic imaging/etiology/physiopathology MH - *Ventricular Function, Left MH - Ventricular Pressure PMC - PMC4574544 EDAT- 2015/09/19 06:00 MHDA- 2016/06/30 06:00 PMCR- 2015/09/18 CRDT- 2015/09/19 06:00 PHST- 2015/07/15 00:00 [received] PHST- 2015/08/26 00:00 [accepted] PHST- 2015/09/19 06:00 [entrez] PHST- 2015/09/19 06:00 [pubmed] PHST- 2016/06/30 06:00 [medline] PHST- 2015/09/18 00:00 [pmc-release] AID - 10.1186/s12933-015-0281-5 [pii] AID - 281 [pii] AID - 10.1186/s12933-015-0281-5 [doi] PST - epublish SO - Cardiovasc Diabetol. 2015 Sep 18;14:123. doi: 10.1186/s12933-015-0281-5.