PMID- 26382221 OWN - NLM STAT- MEDLINE DCOM- 20161005 LR - 20181202 IS - 1938-0682 (Electronic) IS - 1558-7673 (Linking) VI - 14 IP - 1 DP - 2016 Feb TI - Absence of Significant Correlation of Adverse Events Between First- and Second-Line Tyrosine Kinase Inhibitors in Patients With Metastatic Renal Cell Carcinoma. PG - e19-24 LID - S1558-7673(15)00198-6 [pii] LID - 10.1016/j.clgc.2015.08.002 [doi] AB - Several adverse events (AEs) are known to be commonly observed during treatment with different tyrosine kinase inhibitors (TKIs) in patients with metastatic renal cell carcinoma (mRCC) patients. However, no significant correlation appears present in the profiles of such AEs between first- and second-line TKI therapies. Therefore, a second-line targeted agent for patients with mRCC could be selected irrespective of the AE profile during first-line TKI therapy. BACKGROUND: Several adverse events (AEs) commonly observed during treatment with different tyrosine kinase inhibitors (TKIs). The objective of the present study was to investigate whether the appearance of such AEs during treatment with first-line TKIs significantly affects the occurrence of AEs during second-line TKI therapy for patients with metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS: The present study included 154 consecutive patients with mRCC treated with second-line TKIs after the discontinuation of first-line TKIs. The association of AEs, including diarrhea, fatigue, hand-foot syndrome, hypertension, and hypothyroidism, between first- and second-line therapies was analyzed in these 154 patients. RESULTS: For all 5 AEs assessed in the present study, the proportion of patients experiencing AEs or those grade >/= 3 during second-line TKI therapy was not significantly different among the following 3 groups: patients without AEs, those with grade /= 3 AEs during first-line TKI therapy. Furthermore, no significant difference was seen in progression-free or overall survival after the introduction of second-line TKIs between patients with and without grade >/= 3 AEs during treatment with first-line TKIs. CONCLUSION: The incidence of AEs or grade >/= 3 AEs during second-line TKI therapy are not dependent on the profiles of AEs during first-line TKI therapy in patients with mRCC. Therefore, AEs that occur during first-line TKI therapy should not affect the selection of second-line targeted agents for patients with mRCC. CI - Copyright (c) 2016 Elsevier Inc. All rights reserved. FAU - Miyake, Hideaki AU - Miyake H AD - Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address: hideakimiyake@hotmail.com. FAU - Imai, Satoshi AU - Imai S AD - Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Harada, Ken-Ichi AU - Harada K AD - Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Fujisawa, Masato AU - Fujisawa M AD - Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan. LA - eng PT - Journal Article DEP - 20150815 PL - United States TA - Clin Genitourin Cancer JT - Clinical genitourinary cancer JID - 101260955 RN - 0 (Antineoplastic Agents) RN - 0 (Imidazoles) RN - 0 (Indazoles) RN - 0 (Indoles) RN - 0 (Phenylurea Compounds) RN - 0 (Protein Kinase Inhibitors) RN - 0 (Pyrroles) RN - 25X51I8RD4 (Niacinamide) RN - 9ZOQ3TZI87 (Sorafenib) RN - C9LVQ0YUXG (Axitinib) RN - V99T50803M (Sunitinib) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Antineoplastic Agents/*adverse effects/therapeutic use MH - Axitinib MH - Carcinoma, Renal Cell/*drug therapy/mortality/secondary MH - Female MH - Humans MH - Imidazoles/adverse effects/therapeutic use MH - Indazoles/adverse effects/therapeutic use MH - Indoles/adverse effects/therapeutic use MH - Kaplan-Meier Estimate MH - Kidney Neoplasms/*drug therapy/mortality/pathology MH - Lung Neoplasms/*drug therapy/mortality/secondary MH - Male MH - Middle Aged MH - Niacinamide/adverse effects/analogs & derivatives/therapeutic use MH - Phenylurea Compounds/adverse effects/therapeutic use MH - Prognosis MH - Protein Kinase Inhibitors/*adverse effects/therapeutic use MH - Pyrroles/adverse effects/therapeutic use MH - Retrospective Studies MH - Sorafenib MH - Sunitinib OTO - NOTNLM OT - Adverse events OT - First-line OT - Metastatic renal cell carcinoma OT - Second-line OT - Tyrosine kinase inhibitors EDAT- 2015/09/19 06:00 MHDA- 2016/10/07 06:00 CRDT- 2015/09/19 06:00 PHST- 2015/05/22 00:00 [received] PHST- 2015/08/02 00:00 [revised] PHST- 2015/08/08 00:00 [accepted] PHST- 2015/09/19 06:00 [entrez] PHST- 2015/09/19 06:00 [pubmed] PHST- 2016/10/07 06:00 [medline] AID - S1558-7673(15)00198-6 [pii] AID - 10.1016/j.clgc.2015.08.002 [doi] PST - ppublish SO - Clin Genitourin Cancer. 2016 Feb;14(1):e19-24. doi: 10.1016/j.clgc.2015.08.002. Epub 2015 Aug 15.