PMID- 26382227 OWN - NLM STAT- MEDLINE DCOM- 20160711 LR - 20181202 IS - 1520-6394 (Electronic) IS - 1091-4269 (Linking) VI - 32 IP - 12 DP - 2015 Dec TI - NEUROBIOLOGICAL PREDICTORS OF RESPONSE TO DORSOLATERAL PREFRONTAL CORTEX REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION IN DEPRESSION: A SYSTEMATIC REVIEW. PG - 871-91 LID - 10.1002/da.22424 [doi] AB - BACKGROUND: A significant proportion of patients with depression fail to respond to psychotherapy and standard pharmacotherapy, leading to treatment-resistant depression (TRD). Due to the significant prevalence of TRD, alternative therapies for depression have emerged as viable treatments in the armamentarium for this disorder. Repetitive transcranial magnetic stimulation (rTMS) is now being offered in clinical practice in broader numbers. Many studies have investigated various different neurobiological predictors of response of rTMS. However, a synthesis of this literature and an understanding of what biological targets predict response is lacking. This review aims to systematically synthesize the literature on the neurobiological predictors of rTMS in patients with depression. METHODS: Medline (1996-2014), Embase (1980-2014), and PsycINFO (1806-2014) were searched under set terms. Two authors reviewed each article and came to consensus on the inclusion and exclusion criteria. All eligible studies were reviewed, duplicates were removed, and data were extracted individually. RESULTS: The search identified 1,673 articles, 41 of which met both inclusion and exclusion criteria. Various biological factors at baseline appear to predict response to rTMS, including levels of certain molecular factors, blood flow in brain regions implicated in depression, electrophysiological findings, and specific genetic polymorphisms. CONCLUSIONS: Significant methodological variability in rTMS treatment protocols limits the ability to generalize conclusions. However, response to treatment may be predicted by baseline frontal lobe blood flow, and presence of polymorphisms of the 5-hydroxytryptamine (5-HT) -1a gene, the LL genotype of the serotonin transporter linked polymorphic region (5-HTTLPR) gene, and Val/Val homozygotes of the brain-derived neurotrophic factor (BDNF) gene. CI - (c) 2015 Wiley Periodicals, Inc. FAU - Silverstein, William K AU - Silverstein WK AD - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. AD - Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. FAU - Noda, Yoshihiro AU - Noda Y AD - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. AD - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. FAU - Barr, Mera S AU - Barr MS AD - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. AD - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. AD - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. FAU - Vila-Rodriguez, Fidel AU - Vila-Rodriguez F AD - Non-Invasive Neurostimulation Therapies Laboratory, Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Rajji, Tarek K AU - Rajji TK AD - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. AD - Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. AD - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. AD - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. FAU - Fitzgerald, Paul B AU - Fitzgerald PB AD - Monash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Melbourne, Victoria, Australia. FAU - Downar, Jonathan AU - Downar J AD - Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. AD - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. AD - MRI-Guided rTMS Clinic, Department of Psychiatry, University Health Network, Toronto, Ontario, Canada. FAU - Mulsant, Benoit H AU - Mulsant BH AD - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. AD - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. FAU - Vigod, Simone AU - Vigod S AD - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. AD - Reproductive Life Stages Program, Women's Mental Health Program, Women's College Hospital, Toronto, Ontario, Canada. FAU - Daskalakis, Zafiris J AU - Daskalakis ZJ AD - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. AD - Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. AD - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. AD - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. FAU - Blumberger, Daniel M AU - Blumberger DM AD - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. AD - Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. AD - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. AD - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. LA - eng GR - Canadian Institutes of Health Research/Canada PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20150918 PL - United States TA - Depress Anxiety JT - Depression and anxiety JID - 9708816 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Serotonin Plasma Membrane Transport Proteins) RN - 333DO1RDJY (Serotonin) RN - HG18B9YRS7 (Valine) SB - IM MH - Blood Flow Velocity MH - Brain-Derived Neurotrophic Factor/metabolism MH - Cerebrovascular Circulation MH - Depressive Disorder/*physiopathology/*therapy MH - Depressive Disorder, Treatment-Resistant/therapy MH - Humans MH - Polymorphism, Genetic MH - Prefrontal Cortex/*metabolism/*physiopathology MH - Retreatment MH - Serotonin/metabolism MH - Serotonin Plasma Membrane Transport Proteins/metabolism MH - Transcranial Magnetic Stimulation/*methods MH - Treatment Outcome MH - Valine/metabolism OTO - NOTNLM OT - neurobiological predictor OT - rTMS OT - treatment-resistant depression EDAT- 2015/09/19 06:00 MHDA- 2016/07/12 06:00 CRDT- 2015/09/19 06:00 PHST- 2015/03/16 00:00 [received] PHST- 2015/08/19 00:00 [revised] PHST- 2015/08/24 00:00 [accepted] PHST- 2015/09/19 06:00 [entrez] PHST- 2015/09/19 06:00 [pubmed] PHST- 2016/07/12 06:00 [medline] AID - 10.1002/da.22424 [doi] PST - ppublish SO - Depress Anxiety. 2015 Dec;32(12):871-91. doi: 10.1002/da.22424. Epub 2015 Sep 18.