PMID- 26382610
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20170103
IS  - 1096-0295 (Electronic)
IS  - 0273-2300 (Linking)
VI  - 73
IP  - 3
DP  - 2015 Dec
TI  - Five-year yield variation in N-nitrosonornicotine and 
      (4-methylnitrosoamino)-1-(3-pyridyl)-1-butanone from the smoke of commercial 
      cigarette brands on the Japanese market.
PG  - 953-9
LID - S0273-2300(15)30068-4 [pii]
LID - 10.1016/j.yrtph.2015.09.019 [doi]
AB  - This study reports on variation in the yields of N-nitrosonornicotine (NNN) and 
      (4-methylnitrosoamino)-1-(3-pyridyl)-1-butanone (NNK) from the mainstream smoke 
      of cigarette brands and describes factors affecting this variation. Yields of NNN 
      and NNK from smoke and tobacco filler, which is blended and cut tobacco filled in 
      a cigarette tube, together with cigarette design parameters, were measured for 11 
      commercial cigarette brands, which were available in Japan from 2009 to 2013. The 
      ranges of the relative standard deviations (RSDs) for NNN from the smoke of each 
      brand were 5.0%-29.9% under International Organization for Standardization (ISO) 
      and 6.3%-26.3% under Health Canada Intense (HCI) smoking regime. When these RSDs 
      were compared with those of tar, nicotine, and carbon monoxide yields in each 
      brand, they were found to be much higher for all of the brands under the HCI, and 
      higher for most of the brands under the ISO smoking regime. In addition, the RSDs 
      of NNN and NNK in smoke were mostly higher than those of KY3R4F which was 
      manufactured in a single batch. It was identified that variation in NNN yields 
      from tobacco filler mainly contribute to variation in NNN yields from smoke.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Hyodo, T
AU  - Hyodo T
AD  - Japan Tobacco Inc., 2-1-1 Toranomon, Minato-ku, Tokyo 105-8422, Japan. Electronic 
      address: takatsugu.hyodo@jt.com.
FAU - Minagawa, K
AU  - Minagawa K
AD  - Japan Tobacco Inc., 2-1-1 Toranomon, Minato-ku, Tokyo 105-8422, Japan.
FAU - Mikita, A
AU  - Mikita A
AD  - Japan Tobacco Inc., 2-1-1 Toranomon, Minato-ku, Tokyo 105-8422, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150914
PL  - Netherlands
TA  - Regul Toxicol Pharmacol
JT  - Regulatory toxicology and pharmacology : RTP
JID - 8214983
RN  - 0 (Nitrosamines)
RN  - 0 (Smoke)
RN  - 7S395EDO61 (4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone)
RN  - X656TZ86DX (N'-nitrosonornicotine)
SB  - IM
MH  - Japan
MH  - Nitrosamines/*analysis
MH  - Quality Control
MH  - Smoke/*analysis
MH  - *Smoking
MH  - Time Factors
MH  - *Tobacco Products/standards
OTO - NOTNLM
OT  - Cigarette smoke
OT  - Japan
OT  - NNK
OT  - NNN
OT  - Variation
EDAT- 2015/09/19 06:00
MHDA- 2016/10/07 06:00
CRDT- 2015/09/19 06:00
PHST- 2015/04/30 00:00 [received]
PHST- 2015/08/20 00:00 [revised]
PHST- 2015/09/12 00:00 [accepted]
PHST- 2015/09/19 06:00 [entrez]
PHST- 2015/09/19 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
AID - S0273-2300(15)30068-4 [pii]
AID - 10.1016/j.yrtph.2015.09.019 [doi]
PST - ppublish
SO  - Regul Toxicol Pharmacol. 2015 Dec;73(3):953-9. doi: 10.1016/j.yrtph.2015.09.019. 
      Epub 2015 Sep 14.