PMID- 26382744
OWN - NLM
STAT- MEDLINE
DCOM- 20160316
LR  - 20220330
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Linking)
VI  - 70
IP  - 12
DP  - 2015 Dec
TI  - Differentiation between primary central nervous system lymphoma and glioblastoma: 
      a comparative study of parameters derived from dynamic susceptibility 
      contrast-enhanced perfusion-weighted MRI.
PG  - 1393-9
LID - S0009-9260(15)00349-9 [pii]
LID - 10.1016/j.crad.2015.08.004 [doi]
AB  - AIM: To evaluate the diagnostic performance of parameters derived from dynamic 
      susceptibility contrast-enhanced perfusion-weighted magnetic resonance imaging, 
      including first-pass slope ratio (FSR), which is potentially easier to derive 
      than the other proposed parameters in this study, for differentiating primary 
      central nervous system lymphoma (PCNSL) from glioblastoma. MATERIALS AND METHODS: 
      Twenty-eight patients (10 PCNSLs and 18 glioblastomas) were analysed. Six 
      perfusion parameters - corrected cerebral blood volume ratio (cCBVR), uncorrected 
      CBV ratio (uCBVR), FSR, leakage coefficient (K2), percentage of signal-intensity 
      recovery measured at the end of the first-pass (PSRend), and PSR measured using 
      mean signal-intensity after the first-pass (PSRmean) - were derived from 
      enhancing areas selected semi-automatically. Comparisons of cCBVR and uCBVR and 
      of PSRend and PSRmean were conducted. The differences between PCNSL and 
      glioblastoma were compared for the six parameters, and their diagnostic 
      performance was evaluated by receiver operating characteristic curve analysis. 
      RESULTS: For both tumours, cCBVR was significantly higher than uCBVR, and PSRend 
      was significantly lower than PSRmean. PCNSL demonstrated lower cCBVR, uCBVR and 
      FSR, and higher K2, PSRend and PSRmean compared with glioblastoma (p=0.0044 or 
      less). On receiver operating characteristic curve analysis, the areas under the 
      curve were 0.822 for cCBVR, 0.944 for uCBVR, 0.917 for FSR, 0.917 for K2, 0.933 
      for PSRend, and 0.894 for PSRmean. No significant difference was observed among 
      the parameters, except cCBVR, which was significantly inferior to uCBVR. 
      CONCLUSIONS: PCNSL can be differentiated from glioblastoma with high diagnostic 
      value using any of the parameters, except cCBVR. FSR demonstrates high 
      differential performance comparable to the other parameters.
CI  - Copyright (c) 2015 The Royal College of Radiologists. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Nakajima, S
AU  - Nakajima S
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate 
      School of Medicine, Kyoto, 606-8507, Japan.
FAU - Okada, T
AU  - Okada T
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate 
      School of Medicine, Kyoto, 606-8507, Japan. Electronic address: 
      tomokada@kuhp.kyoto-u.ac.jp.
FAU - Yamamoto, A
AU  - Yamamoto A
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate 
      School of Medicine, Kyoto, 606-8507, Japan.
FAU - Kanagaki, M
AU  - Kanagaki M
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate 
      School of Medicine, Kyoto, 606-8507, Japan.
FAU - Fushimi, Y
AU  - Fushimi Y
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate 
      School of Medicine, Kyoto, 606-8507, Japan.
FAU - Okada, T
AU  - Okada T
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate 
      School of Medicine, Kyoto, 606-8507, Japan.
FAU - Arakawa, Y
AU  - Arakawa Y
AD  - Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, 
      606-8507, Japan.
FAU - Takagi, Y
AU  - Takagi Y
AD  - Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, 
      606-8507, Japan.
FAU - Miyamoto, S
AU  - Miyamoto S
AD  - Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, 
      606-8507, Japan.
FAU - Togashi, K
AU  - Togashi K
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate 
      School of Medicine, Kyoto, 606-8507, Japan.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20150914
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/pathology
MH  - Brain Neoplasms/diagnosis
MH  - Central Nervous System Neoplasms/*diagnosis
MH  - *Contrast Media
MH  - Diagnosis, Differential
MH  - Female
MH  - Glioblastoma/*diagnosis
MH  - Humans
MH  - *Image Enhancement
MH  - Image Interpretation, Computer-Assisted
MH  - Lymphoma/*diagnosis
MH  - *Magnetic Resonance Angiography
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Young Adult
EDAT- 2015/09/19 06:00
MHDA- 2016/03/17 06:00
CRDT- 2015/09/19 06:00
PHST- 2014/10/05 00:00 [received]
PHST- 2015/06/06 00:00 [revised]
PHST- 2015/08/10 00:00 [accepted]
PHST- 2015/09/19 06:00 [entrez]
PHST- 2015/09/19 06:00 [pubmed]
PHST- 2016/03/17 06:00 [medline]
AID - S0009-9260(15)00349-9 [pii]
AID - 10.1016/j.crad.2015.08.004 [doi]
PST - ppublish
SO  - Clin Radiol. 2015 Dec;70(12):1393-9. doi: 10.1016/j.crad.2015.08.004. Epub 2015 
      Sep 14.