PMID- 26382929
OWN - NLM
STAT- MEDLINE
DCOM- 20160201
LR  - 20151021
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 114
IP  - 10
DP  - 2015 Nov 28
TI  - Lean and obese dietary phenotypes: differences in energy and substrate metabolism 
      and appetite.
PG  - 1724-33
LID - 10.1017/S0007114515003402 [doi]
AB  - This study aimed to characterise lean and obese phenotypes according to diet and 
      body composition, and to compare fasting and postprandial appetite and metabolic 
      profiles following a high-fat test meal. A total of ten lean (BMI40 and 30 kg/m2) 
      high-fat consumers (OHF; >40 % energy from fat) were recruited. Before and 
      following the test meal (4727 kJ (1130 kcal), 77 % fat, 20 % carbohydrate (CHO) 
      and 3 % protein), fasting plasma glucose, insulin, leptin, ghrelin, peptide YY 
      (PYY), RER, RMR and subjective appetite ratings (AR) were measured for 6 h. 
      Thereafter, subjects consumed a self-selected portion of a standardised post-test 
      meal (40 % fat, 45 % CHO and 15 % protein) and reported AR. Fasting (P=0.01) and 
      postprandial (P<0.001) fat oxidation was significantly higher in LHF than in LLF 
      but was not different between LHF and OHF. Although similar between the lean 
      groups, fasting and postprandial energy expenditures were significantly higher in 
      OHF compared with LHF (P<0.01). Despite similar AR across groups, LLF consumed a 
      relatively greater quantity of the post-test meal than did LHF (7.87 (sd 2.96) v. 
      7.23 (sd 2.67) g/kg, P=0.013). The lean groups showed appropriate changes in 
      plasma ghrelin and PYY following the test meal, whereas the OHF group showed a 
      blunted response. In conclusion, the LHF phenotype had a greater capacity for fat 
      oxidation, which may be protective against weight gain. OHF individuals had a 
      blunted appetite hormone response to the high-fat test meal, which may 
      subsequently increase energy intake, driving further weight gain.
FAU - Clamp, Louise
AU  - Clamp L
AD  - 1Department of Human Biology,Division of Exercise Science and Sports Medicine, 
      Faculty of Health Sciences,University of Cape Town,Cape Town 7725,South Africa.
FAU - Hehir, Anthony P J
AU  - Hehir AP
AD  - 2Department of Human Biology,Division of Nutrition and Dietetics, Faculty of 
      Health Sciences,University of Cape Town,Cape Town 7925,South Africa.
FAU - Lambert, Estelle V
AU  - Lambert EV
AD  - 1Department of Human Biology,Division of Exercise Science and Sports Medicine, 
      Faculty of Health Sciences,University of Cape Town,Cape Town 7725,South Africa.
FAU - Beglinger, Christoph
AU  - Beglinger C
AD  - 3Division of Gastroenterology,University Hospital,4031 Basel,Switzerland.
FAU - Goedecke, Julia H
AU  - Goedecke JH
AD  - 4Non-communicable Disease Research Unit,South African Medical Research 
      Council,Tygerberg 7505,South Africa.
LA  - eng
PT  - Journal Article
DEP - 20150918
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Dietary Fats)
RN  - 0 (Ghrelin)
RN  - 106388-42-5 (Peptide YY)
SB  - IM
MH  - Adult
MH  - Appetite/*physiology
MH  - Basal Metabolism
MH  - Body Composition
MH  - Body Mass Index
MH  - *Diet
MH  - Diet, High-Fat
MH  - Dietary Fats/metabolism
MH  - Energy Intake
MH  - Fasting
MH  - Female
MH  - Ghrelin/blood
MH  - Humans
MH  - Obesity/*metabolism/*physiopathology
MH  - Oxidation-Reduction
MH  - Peptide YY/blood
MH  - Phenotype
MH  - Postprandial Period
MH  - Satiation/physiology
MH  - Surveys and Questionnaires
MH  - Thinness/*metabolism
MH  - Weight Gain/physiology
OTO - NOTNLM
OT  - AR appetite ratings
OT  - CHO carbohydrate
OT  - Diet
OT  - FFM fat-free mass
OT  - Fat oxidation
OT  - Ghrelin
OT  - LHF lean high-fat
OT  - LLF lean low-fat
OT  - OHF obese high-fat
OT  - PYY peptide YY
OT  - Peptide YY
OT  - RER
OT  - RMR
OT  - SFQ Short Fat Questionnaire
OT  - TE total energy
OT  - TFEQ Three Factor Eating Questionnaire
EDAT- 2015/09/19 06:00
MHDA- 2016/02/02 06:00
CRDT- 2015/09/19 06:00
PHST- 2015/09/19 06:00 [entrez]
PHST- 2015/09/19 06:00 [pubmed]
PHST- 2016/02/02 06:00 [medline]
AID - S0007114515003402 [pii]
AID - 10.1017/S0007114515003402 [doi]
PST - ppublish
SO  - Br J Nutr. 2015 Nov 28;114(10):1724-33. doi: 10.1017/S0007114515003402. Epub 2015 
      Sep 18.