PMID- 26384386
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20161230
IS  - 1460-2709 (Electronic)
IS  - 1369-3786 (Linking)
VI  - 54
IP  - 2
DP  - 2016 Feb
TI  - Distinct patterns of yeast cell morphology and host responses induced by 
      representative strains of Paracoccidioides brasiliensis (Pb18) and 
      Paracoccidioides lutzii (Pb01).
PG  - 177-88
LID - 10.1093/mmy/myv072 [doi]
AB  - Paracoccidioidomycosis (PCM) is a systemic mycosis, widespread in Latin America. 
      PCM is a granulomatous disease characterized by a polymorphism of lesions 
      depending on the pathogen's virulence, the immune status of the host and its 
      genetic susceptibility. The thermodimorphic fungus Paracoccidioides brasiliensis 
      was considered the only etiologic agent of PCM, yet recent works have shown 
      significant genetic diversity among different strains of P. brasiliensis. 
      Therefore, it has been proposed for a new species within the Paracoccidioides 
      genus, named Paracoccidioides lutzii. To better understand the fungus-host 
      interactions elicited by strains Pb01 and Pb18 as key representatives of P. 
      lutzii and P. brasiliensis, respectively, we carried out studies to investigate 
      differences in morphology, induced immune response, virulence and pathology 
      between these two Paracoccidioides species. Our results demonstrate distinct 
      patterns of host-parasite interaction and pathology caused by Pb18 and Pb01. 
      These results open up new fronts for NEW: clinical studies, which may result in 
      significant consequences for the diagnosis and treatment of PCM. Considering that 
      our results cannot be extended to all strains of both species, more studies about 
      the virulence among Paracoccioides must be explored in the future.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of The 
      International Society for Human and Animal Mycology. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Siqueira, Isaque Medeiros
AU  - Siqueira IM
AD  - Molecular Pathology Post-Graduate Program, Faculty of Medicine, University of 
      Brasilia, D.F., Brazil.
FAU - Fraga, Cecilia Livia Falcomer
AU  - Fraga CL
AD  - Molecular Pathology Post-Graduate Program, Faculty of Medicine, University of 
      Brasilia, D.F., Brazil.
FAU - Amaral, Andre Correa
AU  - Amaral AC
AD  - Biotechnology, Institute of Tropical Pathology and Public Health, Federal 
      University of Goias.
FAU - Souza, Ana Camila Oliveira
AU  - Souza AC
AD  - Molecular Pathology Post-Graduate Program, Faculty of Medicine, University of 
      Brasilia, D.F., Brazil.
FAU - Jeronimo, Marcio Souza
AU  - Jeronimo MS
AD  - Molecular Pathology Post-Graduate Program, Faculty of Medicine, University of 
      Brasilia, D.F., Brazil.
FAU - Correa, Jose Raimundo
AU  - Correa JR
AD  - Biology Institute, University of Brasilia, D.F., Brazil.
FAU - Magalhaes, Kelly Grace
AU  - Magalhaes KG
AD  - Biology Institute, University of Brasilia, D.F., Brazil.
FAU - Inacio, Carlos Antonio
AU  - Inacio CA
AD  - Biology Institute, Department of Entomology and Plant Pathology, Federal Rural 
      University of Rio de Janeiro.
FAU - Ribeiro, Alice Melo
AU  - Ribeiro AM
AD  - Biology Institute, University of Brasilia, D.F., Brazil.
FAU - Burguel, Pedro Henrique
AU  - Burguel PH
AD  - Molecular Pathology Post-Graduate Program, Faculty of Medicine, University of 
      Brasilia, D.F., Brazil.
FAU - Felipe, Maria Sueli
AU  - Felipe MS
AD  - Biology Institute, University of Brasilia, D.F., Brazil Genomic Science and 
      Biotechnology Post-Graduate Program, Catholic University of Brasilia, D.F., 
      Brazil.
FAU - Tavares, Aldo Henrique
AU  - Tavares AH
AD  - Biology Institute, University of Brasilia, D.F., Brazil.
FAU - Bocca, Anamelia Lorenzetti
AU  - Bocca AL
AD  - Biology Institute, University of Brasilia, D.F., Brazil albocca@unb.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150917
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - *Host-Pathogen Interactions
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Paracoccidioides/*cytology/*immunology/pathogenicity
MH  - Paracoccidioidomycosis/immunology/*microbiology/*pathology
MH  - Virulence
OTO - NOTNLM
OT  - Paracoccidioides brasiliensis
OT  - Paracoccidioides lutzii
OT  - Paracoccidioidomycosis
OT  - host-fungal interaction
OT  - morphological patterns
EDAT- 2015/09/19 06:00
MHDA- 2016/10/14 06:00
CRDT- 2015/09/19 06:00
PHST- 2015/07/07 00:00 [accepted]
PHST- 2015/06/10 00:00 [received]
PHST- 2015/09/19 06:00 [entrez]
PHST- 2015/09/19 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - myv072 [pii]
AID - 10.1093/mmy/myv072 [doi]
PST - ppublish
SO  - Med Mycol. 2016 Feb;54(2):177-88. doi: 10.1093/mmy/myv072. Epub 2015 Sep 17.