PMID- 26385540
OWN - NLM
STAT- MEDLINE
DCOM- 20160627
LR  - 20220408
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 234
IP  - 1
DP  - 2015 Oct 30
TI  - Aberrant functional connectivity of resting state networks associated with trait 
      anxiety.
PG  - 25-34
LID - S0925-4927(15)30030-5 [pii]
LID - 10.1016/j.pscychresns.2015.07.006 [doi]
AB  - Trait anxiety, a personality dimension, has been characterized by functional 
      consequences such as increased distractibility, attentional bias in favor of 
      threat-related information and hyper-responsive amygdala. However, literature on 
      the association between resting state brain functional connectivity, as studied 
      using resting state functional magnetic resonance imaging (rs-fMRI), and reported 
      anxiety levels in the sub-clinical population is limited. In the present study, 
      we employed rs-fMRI to investigate the possible alterations in the functional 
      integrity of Resting State Networks (RSNs) associated with trait anxiety of the 
      healthy subjects (15 high anxious and 14 low anxious). The rs-fMRI data was 
      analyzed using independent component analysis and a dual regression approach that 
      was applied on 12 RSNs that were identified using FSL. High anxious subjects 
      showed significantly reduced functional connectivity in regions of the default 
      mode network (posterior cingulate gyrus, middle and superior temporal gyrus, 
      planum polare, supramarginal gyrus, temporal pole, angular gyrus and lateral 
      occipital gyrus) which has been suggested to be involved in episodic memory, 
      theory of mind, self-evaluation, and introspection, and perceptual systems 
      including medial visual network, auditory network and another network involving 
      temporal, parieto-occipital and frontal regions. Reduction in resting state 
      connectivity in regions of the perceptual networks might underlie the perceptual, 
      attentional and working memory deficits associated with trait anxiety. To our 
      knowledge, this is the first study to relate trait anxiety to resting state 
      connectivity using independent component analysis.
CI  - Copyright (c) 2015. Published by Elsevier Ireland Ltd.
FAU - Modi, Shilpi
AU  - Modi S
AD  - Institute of Nuclear Medicine and Allied Sciences (INMAS), Lucknow Road, 
      Timarpur, Delhi, India.
FAU - Kumar, Mukesh
AU  - Kumar M
AD  - Institute of Nuclear Medicine and Allied Sciences (INMAS), Lucknow Road, 
      Timarpur, Delhi, India.
FAU - Kumar, Pawan
AU  - Kumar P
AD  - Institute of Nuclear Medicine and Allied Sciences (INMAS), Lucknow Road, 
      Timarpur, Delhi, India.
FAU - Khushu, Subash
AU  - Khushu S
AD  - Institute of Nuclear Medicine and Allied Sciences (INMAS), Lucknow Road, 
      Timarpur, Delhi, India. Electronic address: skhushu@inmas.drdo.in.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150708
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adult
MH  - Anxiety/*physiopathology
MH  - Attention/physiology
MH  - Brain/*physiopathology
MH  - Brain Mapping/methods
MH  - Diagnostic Self Evaluation
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*physiopathology
MH  - Personality/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Anxiety
OT  - Auditory
OT  - Functional connectivity
OT  - Resting-state fMRI
OT  - Sensory
OT  - Visual
EDAT- 2015/09/20 06:00
MHDA- 2016/06/28 06:00
CRDT- 2015/09/20 06:00
PHST- 2014/09/16 00:00 [received]
PHST- 2015/04/21 00:00 [revised]
PHST- 2015/07/07 00:00 [accepted]
PHST- 2015/09/20 06:00 [entrez]
PHST- 2015/09/20 06:00 [pubmed]
PHST- 2016/06/28 06:00 [medline]
AID - S0925-4927(15)30030-5 [pii]
AID - 10.1016/j.pscychresns.2015.07.006 [doi]
PST - ppublish
SO  - Psychiatry Res. 2015 Oct 30;234(1):25-34. doi: 10.1016/j.pscychresns.2015.07.006. 
      Epub 2015 Jul 8.