PMID- 26385759
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20191210
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Linking)
VI  - 26
IP  - 4
DP  - 2016 Apr
TI  - Distributed category-specific recognition-memory signals in human perirhinal 
      cortex.
PG  - 423-36
LID - 10.1002/hipo.22531 [doi]
AB  - Evidence from a large body of research suggests that perirhinal cortex (PrC), 
      which interfaces the medial temporal lobe with the ventral visual pathway for 
      object identification, plays a critical role in item-based recognition memory. 
      The precise manner in which PrC codes for the prior occurrence of objects, 
      however, remains poorly understood. In the present functional magnetic resonance 
      imaging (fMRI) study, we used multivoxel pattern analyses to examine whether the 
      prior occurrence of faces is coded by distributed patterns of PrC activity that 
      consist of voxels with decreases as well as increases in signal. We also 
      investigated whether pertinent voxels are preferentially tuned to the specific 
      object category to which judged stimuli belong. We found that, when no a priori 
      constraints were imposed on the direction of signal change, activity patterns 
      that allowed for successful classification of recognition-memory decisions 
      included some voxels with decreases and others with increases in signal in 
      association with perceived prior occurrence. Moreover, successful classification 
      was obtained in the absence of a mean difference in activity across the set of 
      voxels in these patterns. Critically, we observed a positive relationship between 
      classifier accuracy and behavioral performance across participants. Additional 
      analyses revealed that voxels carrying diagnostic information for classification 
      of memory decisions showed category specificity in their tuning for faces when 
      probed with an independent functional localizer in a nonmnemonic task context. 
      These voxels were spatially distributed in PrC, and extended beyond the 
      contiguous voxel clusters previously described as the anterior temporal face 
      patch. Our findings provide support for proposals, recently raised in the 
      neurophysiological literature, that the prior occurrence of objects is coded by 
      distributed PrC representations. They also suggest that the stimulus category to 
      which an item belongs shapes the organization of these distributed 
      representations.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Martin, Chris B
AU  - Martin CB
AD  - Department of Psychology, The Brain and Mind Institute, Western University, 
      London, Ontario, Canada.
AD  - Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
FAU - Cowell, Rosemary A
AU  - Cowell RA
AD  - Department of Psychological and Brain Sciences, University of Massachusetts, 
      Amherst, Massachusetts.
FAU - Gribble, Paul L
AU  - Gribble PL
AD  - Department of Psychology, The Brain and Mind Institute, Western University, 
      London, Ontario, Canada.
AD  - Department of Physiology and Pharmacology, Western University, London, Ontario, 
      Canada.
FAU - Wright, Jessey
AU  - Wright J
AD  - Rotman Institute of Philosophy, Western University, London, Ontario, Canada.
AD  - Department of Philosophy, Western University, London, Ontario, Canada.
FAU - Kohler, Stefan
AU  - Kohler S
AD  - Department of Psychology, The Brain and Mind Institute, Western University, 
      London, Ontario, Canada.
AD  - Baycrest Centre, Rotman Research Institute, Toronto, Ontario, Canada.
LA  - eng
GR  - MOP93644/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151019
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Facial Recognition/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neuropsychological Tests
MH  - Perirhinal Cortex/*physiology
MH  - Photic Stimulation
MH  - Recognition, Psychology/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - fMRI
OT  - faces
OT  - familiarity
OT  - medial temporal lobe
OT  - multivoxel pattern analysis
EDAT- 2015/09/20 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/09/20 06:00
PHST- 2015/09/08 00:00 [accepted]
PHST- 2015/09/20 06:00 [entrez]
PHST- 2015/09/20 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1002/hipo.22531 [doi]
PST - ppublish
SO  - Hippocampus. 2016 Apr;26(4):423-36. doi: 10.1002/hipo.22531. Epub 2015 Oct 19.