PMID- 26386404
OWN - NLM
STAT- MEDLINE
DCOM- 20160808
LR  - 20180816
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 152
IP  - Pt A
DP  - 2015 Dec 1
TI  - Institutionalization and indiscriminate social behavior: 
      Differential-susceptibility versus diathesis-stress models for the 5-HTTLPR and 
      BDNF genotypes.
PG  - 85-91
LID - S0031-9384(15)30112-8 [pii]
LID - 10.1016/j.physbeh.2015.09.015 [doi]
AB  - Institutionalization adversely impacts children's emotional functioning, proving 
      related to attachment disorders, perhaps most notably that involving 
      indiscriminate behavior, the subject of this report. In seeking to extend work in 
      this area, this research on gene X environment (GXE) interplay investigated 
      whether the serotonin transporter (5-HTTLPR) and val66met Brain-Derived 
      Neurotrophic Factor (BDNF) polymorphisms moderated the effect of institutional 
      care on indiscriminate behavior in preschoolers. Eighty-five institutionalized 
      and 135 home-reared Portuguese children were assessed using Disturbances of 
      Attachment Interview (DAI). GXE results indicated that s/s homozygotes of the 
      5-HTTLPR gene displayed significantly higher levels of indiscriminate behavior 
      than all other children if institutionalized, something not true of such children 
      when family reared. These findings proved consistent with the diathesis-stress 
      rather than differential-susceptibility model of personxenvironment interaction. 
      BDNF proved unrelated to indiscriminate behavior. Results are discussed in 
      relation to previous work on this subject of indiscriminate behavior, 
      institutionalization and GXE interaction.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Mesquita, A R
AU  - Mesquita AR
AD  - Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, 
      Campus de Gualtar, 4710 057 Braga, Portugal. Electronic address: 
      ana.mesquita@psi.uminho.uminho.pt.
FAU - Belsky, J
AU  - Belsky J
AD  - Department of Human Ecology, University of California, Davis, One Shields Avenue, 
      Davis, CA 95616, USA. Electronic address: jbelsky@ucdavis.edu.
FAU - Li, Z
AU  - Li Z
AD  - Department of Human Ecology, University of California, Davis, One Shields Avenue, 
      Davis, CA 95616, USA. Electronic address: zhdli@ucdavis.edu.
FAU - Baptista, J
AU  - Baptista J
AD  - Psychotherapy and Psychopathology Research Unit, CIPsi, School of Psychology, 
      University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal. Electronic 
      address: joana.baptista.mail@gmail.com.
FAU - Carvalho-Correia, E
AU  - Carvalho-Correia E
AD  - Psychotherapy and Psychopathology Research Unit, CIPsi, School of Psychology, 
      University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal. Electronic 
      address: eduardaicorreia@ecsaude.uminho.pt.
FAU - Maciel, P
AU  - Maciel P
AD  - Life and Health Sciences Research Institute (ICVS), School of Health Sciences, 
      University of Minho, 4710-057 Braga, Portugal; ICVS/3Bs, PT Government Associate 
      Laboratory, Braga, Guimaraes, Portugal. Electronic address: 
      pmaciel@ecsaude.uminho.pt.
FAU - Soares, I
AU  - Soares I
AD  - Psychotherapy and Psychopathology Research Unit, CIPsi, School of Psychology, 
      University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal. Electronic 
      address: isoares@psi.uminho.pt.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150918
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Child, Institutionalized/*psychology
MH  - Child, Preschool
MH  - Family/psychology
MH  - Female
MH  - Gene-Environment Interaction
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Infant
MH  - Interview, Psychological
MH  - Male
MH  - Models, Genetic
MH  - Models, Psychological
MH  - *Object Attachment
MH  - *Polymorphism, Genetic
MH  - Portugal
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - *Social Behavior
OTO - NOTNLM
OT  - 5-HTTLPR
OT  - BDNF
OT  - Diathesis-stress
OT  - Differential susceptibility
OT  - Indiscriminate behavior
OT  - Institutionalization
EDAT- 2015/09/20 06:00
MHDA- 2016/08/09 06:00
CRDT- 2015/09/20 06:00
PHST- 2015/02/10 00:00 [received]
PHST- 2015/04/16 00:00 [revised]
PHST- 2015/09/14 00:00 [accepted]
PHST- 2015/09/20 06:00 [entrez]
PHST- 2015/09/20 06:00 [pubmed]
PHST- 2016/08/09 06:00 [medline]
AID - S0031-9384(15)30112-8 [pii]
AID - 10.1016/j.physbeh.2015.09.015 [doi]
PST - ppublish
SO  - Physiol Behav. 2015 Dec 1;152(Pt A):85-91. doi: 10.1016/j.physbeh.2015.09.015. 
      Epub 2015 Sep 18.