PMID- 26387843
OWN - NLM
STAT- MEDLINE
DCOM- 20180131
LR  - 20221207
IS  - 1532-1983 (Electronic)
IS  - 0261-5614 (Linking)
VI  - 35
IP  - 5
DP  - 2016 Oct
TI  - Gene and dietary calcium interaction effects on brachial-ankle pulse wave 
      velocity.
PG  - 1127-34
LID - S0261-5614(15)00230-7 [pii]
LID - 10.1016/j.clnu.2015.08.009 [doi]
AB  - BACKGROUND & AIM: Understanding the lifestyle and genetic factors that affect 
      pulse wave velocity (PWV) may provide clues to preventing atherosclerotic 
      cardiovascular events. The aim of this study is to investigate genome-wide 
      genetic and dietary calcium (Ca) intake interaction effects on brachial-ankle 
      pulse wave velocity (baPWV). METHODS: The baPWV was measured, and Ca intake was 
      quantified by administering a food frequency questionnaire (FFQ) to 3198 
      participants, which included men and women (>/=40 years) from the Korean 
      Multi-Rural communities Cohort study (MRCohort). The interaction effects of 
      dietary Ca intake and 19 single-nucleotide polymorphisms (SNPs) on baPWV were 
      assessed using the general linear models. RESULTS: Dietary Ca intake was not 
      significantly associated with baPWV or any type of SNP among the subjects herein. 
      In men, however, the adducin1 (ADD1) rs4961_C SNP had a significant dietary Ca 
      intake-dependent effect on mean baPWV (pinteraction = 0.002). In women, the 
      interaction of zinc finger proteins 618 (ZNF618) rs10817542_A with dietary Ca 
      intake played a significant and key role in mean baPWV (pinteraction = 0.001). In 
      the results of ADD1 rs4961_C in men and ZNF618 rs10817542_A in women, the minor 
      allele-lowest Ca intake tertile (T1) group had significantly higher mean baPWV 
      value than other subgroups of Ca intake tertile-genotype cross-classification 
      whereas genotype was not a significant effector on mean baPWV values among 
      highest Ca intake subgroups (T3). CONCLUSIONS: The baPWV, a phenotype of arterial 
      stiffness, can be modulated in subjects through regulation of dietary Ca intake, 
      particularly in subjects with more vulnerable genotypes.
CI  - Copyright (c) 2015 Elsevier Ltd and European Society for Clinical Nutrition and 
      Metabolism. All rights reserved.
FAU - Choi, SeongIl
AU  - Choi S
AD  - Department of Cardiology, Guri Hospital, College of Medicine, Hanyang University, 
      Guri, South Korea.
FAU - Jung, Sukyoung
AU  - Jung S
AD  - Department of Preventive Medicine, College of Medicine, Hanyang University, 
      Seoul, South Korea; Institute for Health and Society, Hanyang University, Seoul, 
      South Korea.
FAU - Kim, Mi Kyung
AU  - Kim MK
AD  - Department of Preventive Medicine, College of Medicine, Hanyang University, 
      Seoul, South Korea; Institute for Health and Society, Hanyang University, Seoul, 
      South Korea. Electronic address: kmkkim@hanyang.ac.kr.
FAU - Shin, Jinho
AU  - Shin J
AD  - Division of Cardiology, Department of Internal Medicine, Hanyang University, 
      College of Medicine, Seoul, South Korea.
FAU - Shin, Min-Ho
AU  - Shin MH
AD  - Department of Preventive Medicine, Chonnam National University Medical School, 
      Gwangju, South Korea; Jeonnam Regional Cancer Center, Chonnam National University 
      Hwasun Hospital, Hwasun, South Korea.
FAU - Shin, Dong Hoon
AU  - Shin DH
AD  - Department of Preventive Medicine, School of Medicine, Keimyung University, 
      Daegu, South Korea.
FAU - Lee, Young-Hoon
AU  - Lee YH
AD  - Department of Preventive Medicine, Institute of Wonkwang Medical Science, 
      Wonkwang University College of Medicine, Iksan, South Korea.
FAU - Chun, Byung-Yeol
AU  - Chun BY
AD  - Department of Preventive Medicine, School of Medicine, Health Promotion Research 
      Center, Kyungpook National University, Daegu, South Korea.
FAU - Hong, Kyung-Won
AU  - Hong KW
AD  - Center for Genome Science, National Institute of Health, Osong Health Technology 
      Administration Complex, Chungcheongbuk-do, South Korea.
FAU - Hwang, Joo-Yeon
AU  - Hwang JY
AD  - Center for Genome Science, National Institute of Health, Osong Health Technology 
      Administration Complex, Chungcheongbuk-do, South Korea.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20150906
PL  - England
TA  - Clin Nutr
JT  - Clinical nutrition (Edinburgh, Scotland)
JID - 8309603
RN  - 0 (Calcium, Dietary)
RN  - 0 (Calmodulin-Binding Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Triglycerides)
RN  - 0 (adducin)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - *Ankle Brachial Index
MH  - Asian People/*genetics
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Calcium, Dietary/*administration & dosage
MH  - Calmodulin-Binding Proteins/genetics/metabolism
MH  - Cholesterol/blood
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Diet
MH  - Female
MH  - Genotyping Techniques
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nutrition Assessment
MH  - Polymorphism, Single Nucleotide
MH  - *Pulse Wave Analysis
MH  - Republic of Korea
MH  - Risk Factors
MH  - Rural Population
MH  - Surveys and Questionnaires
MH  - Triglycerides/blood
MH  - Vascular Stiffness
OTO - NOTNLM
OT  - Arterial stiffness
OT  - Dietary calcium intake
OT  - Gene-diet interaction
OT  - Single-nucleotide polymorphisms
EDAT- 2015/09/22 06:00
MHDA- 2018/02/01 06:00
CRDT- 2015/09/22 06:00
PHST- 2014/11/16 00:00 [received]
PHST- 2015/08/08 00:00 [revised]
PHST- 2015/08/29 00:00 [accepted]
PHST- 2015/09/22 06:00 [entrez]
PHST- 2015/09/22 06:00 [pubmed]
PHST- 2018/02/01 06:00 [medline]
AID - S0261-5614(15)00230-7 [pii]
AID - 10.1016/j.clnu.2015.08.009 [doi]
PST - ppublish
SO  - Clin Nutr. 2016 Oct;35(5):1127-34. doi: 10.1016/j.clnu.2015.08.009. Epub 2015 Sep 
      6.