PMID- 26388728 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150921 LR - 20220317 IS - 1662-5099 (Print) IS - 1662-5099 (Electronic) IS - 1662-5099 (Linking) VI - 8 DP - 2015 TI - Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats. PG - 49 LID - 10.3389/fnmol.2015.00049 [doi] LID - 49 AB - Early life adversity, such as postnatal maternal separation (MS), play a central role in the development of psychopathologies during individual ontogeny. In this study, we investigated the effects of repeated MS (4 h per day from postnatal day (PND) 1-21) on the brain-derived neurotrophic factor (BDNF) expression in the medial prefrontal cortex (mPFC), the nucleus accumbens (NAc) and the hippocampus of male and female juvenile (PND 21), adolescent (PND 35) and young adult (PND 56) Wistar rats. The results indicated that MS increased BDNF in the CA1 and the dentate gyrus (DG) of adolescent rats as well as in the DG of young adult rats. However, the expression of BDNF in the mPFC in the young adult rats was decreased by MS. Additionally, in the hippocampus, there was decreased BDNF expression with age in both the MS and non separated rats. However, in the mPFC, the BDNF expression was increased with age in the non separated rats; nevertheless, the BDNF expression was significantly decreased in the MS young adult rats. In the NAc, the BDNF expression was increased with age in the male non-maternal separation (NMS) rats, and the young adult female MS rats had less BDNF expression than the adolescent female MS rats. The present study shows unique age-differently changes on a molecular level induced by MS and advances the use of MS as a valid animal model to detect the underlying neurobiological mechanisms of mental disorders. FAU - Wang, Qiong AU - Wang Q AD - Department of Psychology, Peking University Beijing, China. FAU - Shao, Feng AU - Shao F AD - Department of Psychology, Peking University Beijing, China. FAU - Wang, Weiwen AU - Wang W AD - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences Beijing, China. LA - eng PT - Journal Article DEP - 20150901 PL - Switzerland TA - Front Mol Neurosci JT - Frontiers in molecular neuroscience JID - 101477914 PMC - PMC4555027 OTO - NOTNLM OT - brain-derived neurotrophic factor (BDNF) OT - hippocampus OT - maternal separation OT - medial prefrontal cortex (mPFC) EDAT- 2015/09/22 06:00 MHDA- 2015/09/22 06:01 PMCR- 2015/01/01 CRDT- 2015/09/22 06:00 PHST- 2015/04/27 00:00 [received] PHST- 2015/08/18 00:00 [accepted] PHST- 2015/09/22 06:00 [entrez] PHST- 2015/09/22 06:00 [pubmed] PHST- 2015/09/22 06:01 [medline] PHST- 2015/01/01 00:00 [pmc-release] AID - 10.3389/fnmol.2015.00049 [doi] PST - epublish SO - Front Mol Neurosci. 2015 Sep 1;8:49. doi: 10.3389/fnmol.2015.00049. eCollection 2015.