PMID- 26391339
OWN - NLM
STAT- MEDLINE
DCOM- 20160627
LR  - 20221207
IS  - 1873-6246 (Electronic)
IS  - 0301-0511 (Linking)
VI  - 112
DP  - 2015 Dec
TI  - Abnormal degree centrality of functional hubs associated with negative coping in 
      older Chinese adults who lost their only child.
PG  - 46-55
LID - S0301-0511(15)30054-5 [pii]
LID - 10.1016/j.biopsycho.2015.09.005 [doi]
AB  - The loss of an only child is a negative life event and may potentially increase 
      the risk of psychiatric disorders. However, the psychological consequences of the 
      loss of an only child and the associated neural mechanisms remain largely 
      unexplored. Degree centrality (DC), derived from resting-state functional 
      magnetic resonance imaging (fMRI), was used to examine network communication in 
      22 older adults who lost their only child and 23 matched controls. The older 
      adults who lost their only child exhibited an ineffective coping style. They also 
      showed decreased distant and local DC in the precuneus and left inferior parietal 
      lobule and decreased distant DC in the bilateral dorsolateral prefrontal cortex 
      (DLPFC). Furthermore, the decreased local and distant DC of these regions and the 
      decreased DLPFC-precuneus connectivity strength were negatively correlated with 
      negative coping scores in the loss group but not in the controls. Overall, the 
      results suggested a model that the impaired neural network communication of brain 
      hubs within the default mode network (DMN) and central executive network (CEN) 
      were associated with a negative coping style in older adults who lost their only 
      child. The decreased connectivity of the hubs can be identified as a neural risk 
      factor that is related to future psychopathology.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Liu, Wei
AU  - Liu W
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China.
FAU - Liu, HuiJuan
AU  - Liu H
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China.
FAU - Wei, Dongtao
AU  - Wei D
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China.
FAU - Sun, Jiangzhou
AU  - Sun J
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China.
FAU - Yang, Junyi
AU  - Yang J
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China.
FAU - Meng, Jie
AU  - Meng J
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China.
FAU - Wang, Lihong
AU  - Wang L
AD  - Department of Psychiatry, University of Connecticut Health Center, Farmington, 
      USA.
FAU - Qiu, Jiang
AU  - Qiu J
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing, China; Department of Psychology, Southwest University, Chongqing, 
      China. Electronic address: qiuj318@swu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150921
PL  - Netherlands
TA  - Biol Psychol
JT  - Biological psychology
JID - 0375566
SB  - IM
MH  - Adaptation, Psychological/*physiology
MH  - Aged
MH  - Asian People
MH  - *Bereavement
MH  - Brain/*physiology
MH  - Brain Mapping
MH  - Female
MH  - Humans
MH  - *Life Change Events
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/physiology
OTO - NOTNLM
OT  - Coping style
OT  - Degree centrality
OT  - Functional connectivity
OT  - Only child losing
OT  - Resting state fMRI
EDAT- 2015/09/24 06:00
MHDA- 2016/06/28 06:00
CRDT- 2015/09/23 06:00
PHST- 2015/06/29 00:00 [received]
PHST- 2015/08/17 00:00 [revised]
PHST- 2015/09/14 00:00 [accepted]
PHST- 2015/09/23 06:00 [entrez]
PHST- 2015/09/24 06:00 [pubmed]
PHST- 2016/06/28 06:00 [medline]
AID - S0301-0511(15)30054-5 [pii]
AID - 10.1016/j.biopsycho.2015.09.005 [doi]
PST - ppublish
SO  - Biol Psychol. 2015 Dec;112:46-55. doi: 10.1016/j.biopsycho.2015.09.005. Epub 2015 
      Sep 21.