PMID- 26391515
OWN - NLM
STAT- MEDLINE
DCOM- 20160819
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 Sep 22
TI  - T cell immunity to glatiramer acetate ameliorates cognitive deficits induced by 
      chronic cerebral hypoperfusion by modulating the microenvironment.
PG  - 14308
LID - 10.1038/srep14308 [doi]
LID - 14308
AB  - Vascular dementia (VaD) is a progressive and highly prevalent disorder. However, 
      in a very large majority of cases, a milieu of cellular and molecular events 
      common for multiple neurodegenerative diseases is involved. Our work focused on 
      whether the immunomodulating effect of glatiramer acetate (GA) could restore 
      normalcy to the microenvironment and ameliorate cognitive decline induced by 
      chronic cerebral hypoperfusion. We assessed cognitive function by rats' 
      performance in a Morris water maze (MWM), electrophysiological recordings and by 
      pathologic changes. The results suggest that GA reduced cognitive deficits by 
      reestablishing an optimal microenvironment such as increasing expression of the 
      brain-derived neurotrophic factor (BDNF) and modulating the Th1/Th2 cytokine 
      balance in the hippocampus. When microenvironmental homeostasis is restored, 
      cholinergic activity becomes involved in ameliorating cellular damage. Since 
      vaccination with GA can boost "protective autoimmunity" in this way, a similar 
      strategy may have therapeutic potential for alleviating VaD disease.
FAU - Chen, Li
AU  - Chen L
AD  - Department of Neurology and Tianjin Neurological Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
FAU - Yao, Yang
AU  - Yao Y
AD  - Department of Neurology and Tianjin Neurological Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
FAU - Wei, Changjuan
AU  - Wei C
AD  - Department of Neurology and Tianjin Neurological Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
FAU - Sun, Yanan
AU  - Sun Y
AD  - Department of Neurology and Tianjin Neurological Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
FAU - Ma, Xiaofeng
AU  - Ma X
AD  - Department of Neurology and Tianjin Neurological Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
FAU - Zhang, Rongxin
AU  - Zhang R
AD  - Center for Basic Medical Science Research, Tianjin Medical University, Tianjin 
      300070, China.
FAU - Xu, Xiaolin
AU  - Xu X
AD  - Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300060, China.
FAU - Hao, Junwei
AU  - Hao J
AD  - Department of Neurology and Tianjin Neurological Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150922
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Aif1 protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Microfilament Proteins)
RN  - 5M691HL4BO (Glatiramer Acetate)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain Ischemia/*complications/*immunology/metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Calcium-Binding Proteins/genetics/metabolism
MH  - Cognition Disorders/*etiology/metabolism
MH  - Cytokines/metabolism
MH  - Dementia, Vascular/etiology
MH  - Disease Models, Animal
MH  - Glatiramer Acetate/*immunology/pharmacology
MH  - Glial Fibrillary Acidic Protein/genetics/metabolism
MH  - Hippocampus/metabolism
MH  - Long-Term Potentiation/drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Microfilament Proteins/genetics/metabolism
MH  - Rats
MH  - T-Lymphocytes/*immunology/metabolism
PMC - PMC4585746
EDAT- 2015/09/24 06:00
MHDA- 2016/08/20 06:00
PMCR- 2015/09/22
CRDT- 2015/09/23 06:00
PHST- 2015/03/20 00:00 [received]
PHST- 2015/08/24 00:00 [accepted]
PHST- 2015/09/23 06:00 [entrez]
PHST- 2015/09/24 06:00 [pubmed]
PHST- 2016/08/20 06:00 [medline]
PHST- 2015/09/22 00:00 [pmc-release]
AID - srep14308 [pii]
AID - 10.1038/srep14308 [doi]
PST - epublish
SO  - Sci Rep. 2015 Sep 22;5:14308. doi: 10.1038/srep14308.