PMID- 26391639
OWN - NLM
STAT- MEDLINE
DCOM- 20170227
LR  - 20221207
IS  - 1541-1087 (Electronic)
IS  - 0731-5724 (Linking)
VI  - 35
IP  - 5
DP  - 2016 Jul
TI  - The Effect of Vitamin D Supplementation on Glycemic Control and Lipid Profile in 
      Patients with Type 2 Diabetes Mellitus.
PG  - 399-404
LID - 10.1080/07315724.2015.1026427 [doi]
AB  - AIM: The aim of this study was to evaluate the effect of vitamin D 
      supplementation in patients with type 2 diabetes mellitus (T2DM) with regard to 
      their glycemic control and lipid profile. METHODS: One hundred subjects with T2DM 
      were recruited and given 4500 IU/day of vitamin D for 2 months. 25-Hydroxyvitamin 
      D [25(OH)D], fasting blood glucose (FBG), glycosylated hemoglobin A1c (HbA1c), 
      and lipid profile were measured pre- and postsupplementation. RESULTS: There was 
      a significant increase in the mean value of 25(OH)D level after supplementation 
      (baseline level 16 +/- 5.3 ng/ml vs. after supplement level 49.2 +/- 17.7 ng/ml, p < 
      0.05). Both FBG and HbA1c but not lipid profile were significantly decreased 
      after supplementation. However, the univariate general linear model between 
      25(OH)D percentiles and lipid profile levels showed that diabetic subjects with 
      high 25(OH)D levels (>61 ng/ml) had significantly lower levels of total 
      cholesterol and low-density lipoprotein cholesterol (LDL-C) in comparison to 
      those in the low or middle percentiles. Furthermore, participants in a higher 
      percentile had a significantly higher level of high-density lipoprotein 
      cholesterol (HDL-C) than those in the middle percentile. Lipid profile levels 
      were not affected by the supplement except for triglycerides (TG) levels in 
      females, which were significantly decreased. CONCLUSIONS: Vitamin D 
      supplementation may be beneficial to diabetic subjects because it improved 
      glycemic control. Diabetic subjects with high 25(OH)D levels (>61 ng/ml) had 
      better lipid profiles.
FAU - Mohamad, Magda I
AU  - Mohamad MI
AD  - a Medical Biochemistry Department.
FAU - El-Sherbeny, Enas E
AU  - El-Sherbeny EE
AD  - c Faculty of Medicine, Ain Shams University, Cairo, EGYPT; Public Health & 
      Community Medicine Department , Faculty of Medicine, Mansoura University, 
      Mansoura, EGYPT.
FAU - Bekhet, Meram M
AU  - Bekhet MM
AD  - b Endocrinology Department.
LA  - eng
PT  - Journal Article
DEP - 20150921
PL  - United States
TA  - J Am Coll Nutr
JT  - Journal of the American College of Nutrition
JID - 8215879
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
RN  - 1406-16-2 (Vitamin D)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*analysis
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Diabetes Mellitus, Type 2/*blood/*drug therapy
MH  - Dietary Supplements
MH  - Fasting
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - Sex Factors
MH  - Vitamin D/*administration & dosage/analogs & derivatives/blood
OTO - NOTNLM
OT  - 25-hydroxyvitamin D
OT  - diabetes mellitus
OT  - glycemic control
OT  - lipid profile
OT  - vitamin D
EDAT- 2015/09/24 06:00
MHDA- 2017/02/28 06:00
CRDT- 2015/09/23 06:00
PHST- 2015/09/23 06:00 [entrez]
PHST- 2015/09/24 06:00 [pubmed]
PHST- 2017/02/28 06:00 [medline]
AID - 10.1080/07315724.2015.1026427 [doi]
PST - ppublish
SO  - J Am Coll Nutr. 2016 Jul;35(5):399-404. doi: 10.1080/07315724.2015.1026427. Epub 
      2015 Sep 21.