PMID- 26391661
OWN - NLM
STAT- MEDLINE
DCOM- 20151224
LR  - 20200204
IS  - 1540-8140 (Electronic)
IS  - 0021-9525 (Print)
IS  - 0021-9525 (Linking)
VI  - 210
IP  - 7
DP  - 2015 Sep 28
TI  - A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 
      activation and BDNF release.
PG  - 1225-37
LID - 10.1083/jcb.201504092 [doi]
AB  - Estrogen is an important modulator of hippocampal synaptic plasticity and memory 
      consolidation through its rapid action on membrane-associated receptors. Here, we 
      found that both estradiol and the G-protein-coupled estrogen receptor 1 (GPER1) 
      specific agonist G1 rapidly induce brain-derived neurotrophic factor (BDNF) 
      release, leading to transient stimulation of activity-regulated 
      cytoskeleton-associated (Arc) protein translation and GluA1-containing AMPA 
      receptor internalization in field CA3 of hippocampus. We also show that type-I 
      metabotropic glutamate receptor (mGluR) activation does not induce Arc 
      translation nor long-term depression (LTD) at the mossy fiber pathway, as opposed 
      to its effects in CA1, and it only triggers LTD after GPER1 stimulation. 
      Furthermore, this form of mGluR-dependent LTD is associated with ubiquitination 
      and proteasome-mediated degradation of GluA1, and is prevented by proteasome 
      inhibition. Overall, our study identifies a novel mechanism by which estrogen and 
      BDNF regulate hippocampal synaptic plasticity in the adult brain.
CI  - (c) 2015 Briz et al.
FAU - Briz, Victor
AU  - Briz V
AD  - Graduate College of Biomedical Sciences, Western University of Health Sciences, 
      Pomona, CA 91766 VIB Center for the Biology of Disease, Katholieke Universiteit 
      Leuven, 3000 Leuven, Belgium.
FAU - Liu, Yan
AU  - Liu Y
AD  - Graduate College of Biomedical Sciences, Western University of Health Sciences, 
      Pomona, CA 91766 College of Osteopathic Medicine of the Pacific, Western 
      University of Health Sciences, Pomona, CA 91766.
FAU - Zhu, Guoqi
AU  - Zhu G
AD  - Graduate College of Biomedical Sciences, Western University of Health Sciences, 
      Pomona, CA 91766 Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui 
      University of Traditional Chinese Medicine, Hefei 230038, China.
FAU - Bi, Xiaoning
AU  - Bi X
AD  - College of Osteopathic Medicine of the Pacific, Western University of Health 
      Sciences, Pomona, CA 91766.
FAU - Baudry, Michel
AU  - Baudry M
AD  - Graduate College of Biomedical Sciences, Western University of Health Sciences, 
      Pomona, CA 91766 mbaudry@westernu.edu.
LA  - eng
GR  - P01 NS045260/NS/NINDS NIH HHS/United States
GR  - R15 MH101703/MH/NIMH NIH HHS/United States
GR  - P01NS045260-01/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150921
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Gper1 protein, rat)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (metabotropic glutamate receptor type 1)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
RN  - TFZ3H25BS1 (glutamate receptor ionotropic, AMPA 1)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - CA3 Region, Hippocampal/cytology/*metabolism
MH  - Male
MH  - Neuronal Plasticity/*physiology
MH  - Proteasome Endopeptidase Complex/metabolism
MH  - Proteolysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, AMPA/metabolism
MH  - Receptors, G-Protein-Coupled/*metabolism
MH  - Receptors, Metabotropic Glutamate/metabolism
PMC - PMC4586750
EDAT- 2015/09/24 06:00
MHDA- 2015/12/25 06:00
PMCR- 2016/03/28
CRDT- 2015/09/23 06:00
PHST- 2015/04/21 00:00 [received]
PHST- 2015/08/19 00:00 [accepted]
PHST- 2015/09/23 06:00 [entrez]
PHST- 2015/09/24 06:00 [pubmed]
PHST- 2015/12/25 06:00 [medline]
PHST- 2016/03/28 00:00 [pmc-release]
AID - jcb.201504092 [pii]
AID - 201504092 [pii]
AID - 10.1083/jcb.201504092 [doi]
PST - ppublish
SO  - J Cell Biol. 2015 Sep 28;210(7):1225-37. doi: 10.1083/jcb.201504092. Epub 2015 
      Sep 21.