PMID- 26391958
OWN - NLM
STAT- MEDLINE
DCOM- 20160718
LR  - 20181113
IS  - 1433-0407 (Electronic)
IS  - 0028-2804 (Linking)
VI  - 86
IP  - 10
DP  - 2015 Oct
TI  - [Polymorphism of brain derived neurotrophic factor and recovery of functions 
      after ischemic stroke].
PG  - 1255-60
LID - 10.1007/s00115-015-4325-6 [doi]
AB  - BACKGROUND: After ischemic stroke, many factors influence the restitution of 
      functions. In particular they include the patient age, the initial stroke 
      severity and the presence of cognitive and neuropsychological deficits. In this 
      study we investigated whether a polymorphism in the gene encoding for brain 
      derived neurotrophic factor (BDNF) influences improvements of motor functions and 
      everyday activities. METHODS: Patients with subacute ischemic stroke (n = 67) 
      were examined at the beginning of an inpatient neurological rehabilitation, after 
      4 weeks of treatment and after 6 months. The Barthel index (BI) and the Rivermead 
      motor assessment (RMA) were used to measure motor functions and everyday 
      activities. Patients were allocated to three groups (valine [Val]/valine, 
      val/methionine [Met] and Met/Met) depending on the BDNF polymorphism at codon 66. 
      RESULTS: The 3 groups (Val/Val, n = 34 patients, Val/Met, n = 26 and Met/Met, 
      n = 7) showed significant improvements in BI and RMA after 4 weeks and after 6 
      months as compared to the preceding measurements. The BI and RMA were positively 
      correlated. The three groups did not differ with respect to the extent of 
      improvement. CONCLUSION: After ischemic stroke, motor functions and everyday 
      activities improved continuously over a period of at least 6 months. The BDNF 
      polymorphism did not influence this development.
FAU - Liepert, J
AU  - Liepert J
AD  - Abteilung fur Neurorehabilitation, Kliniken Schmieder, Zum Tafelholz 8, 78476, 
      Allensbach, Deutschland. j.liepert@kliniken-schmieder.de.
FAU - Heller, A
AU  - Heller A
AD  - Abteilung fur Neurorehabilitation, Kliniken Schmieder, Zum Tafelholz 8, 78476, 
      Allensbach, Deutschland.
FAU - Behnisch, G
AU  - Behnisch G
AD  - Abteilung fur Verhaltensneurologie, Leibniz Institut fur Neurobiologie, 
      Magdeburg, Deutschland.
FAU - Schoenfeld, A
AU  - Schoenfeld A
AD  - Abteilung fur Neurorehabilitation, Kliniken Schmieder, Zum Tafelholz 8, 78476, 
      Allensbach, Deutschland.
AD  - Abteilung fur Verhaltensneurologie, Leibniz Institut fur Neurobiologie, 
      Magdeburg, Deutschland.
AD  - Neurologische Klinik, Otto-von-Guericke Universitat, Magdeburg, Deutschland.
LA  - ger
PT  - Journal Article
TT  - Polymorphismus des "brain derived neurotrophic factor" und Erholung nach 
      Schlaganfall.
PL  - Germany
TA  - Nervenarzt
JT  - Der Nervenarzt
JID - 0400773
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Genetic Markers)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Causality
MH  - Female
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/epidemiology/genetics
MH  - Germany/epidemiology
MH  - Humans
MH  - Incidence
MH  - Longitudinal Studies
MH  - Male
MH  - Movement Disorders/epidemiology/*genetics/*rehabilitation
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Recovery of Function/*genetics
MH  - Risk Assessment
MH  - Stroke/epidemiology/*genetics
MH  - Stroke Rehabilitation
OTO - NOTNLM
OT  - BDNF
OT  - Barthel index
OT  - Ischemic stroke
OT  - Recovery of functions
OT  - Rivermead motor assessment
EDAT- 2015/09/24 06:00
MHDA- 2016/07/19 06:00
CRDT- 2015/09/23 06:00
PHST- 2015/09/23 06:00 [entrez]
PHST- 2015/09/24 06:00 [pubmed]
PHST- 2016/07/19 06:00 [medline]
AID - 10.1007/s00115-015-4325-6 [pii]
AID - 10.1007/s00115-015-4325-6 [doi]
PST - ppublish
SO  - Nervenarzt. 2015 Oct;86(10):1255-60. doi: 10.1007/s00115-015-4325-6.