PMID- 26393277
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20151224
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 58
DP  - 2015 Dec
TI  - New Zealand white rabbit progeny exposed in utero to methanol are resistant to 
      skeletal anomalies reported for rodents, but exhibit a novel vertebral defect.
PG  - 104-10
LID - S0890-6238(15)30022-8 [pii]
LID - 10.1016/j.reprotox.2015.09.004 [doi]
AB  - Rabbits may serve as a useful model for predicting the human risk for methanol 
      (MeOH) teratogenicity, which currently is unknown. New Zealand white (NZW) 
      rabbits are resistant to the MeOH-initiated gross morphological anomalies 
      characteristically observed in several strains of mice and rats, but skeletal 
      development has not been assessed. Pregnant rabbits were administered 2 doses of 
      2g/kg MeOH on gestational day (GD) 7 or 8, and assessed for skeletal 
      abnormalities on GD 29. Variations between treated and control fetuses were 
      observed only in the number of post-lumbar vertebrae, where MeOH-exposed fetuses 
      had fewer ossified vertebrae, which has not been reported for rodents. 
      Furthermore, rabbits did not exhibit the MeOH-initiated skeletal defects 
      characteristically reported for rodent fetuses. These results expand the 
      morphological breadth of the relative species-dependent resistance of rabbits to 
      MeOH teratogenicity compared to rodents, yet reveal a novel skeletal defect or 
      delay in ossification not reported for rodents.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Sweeting, J Nicole
AU  - Sweeting JN
AD  - Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
FAU - Wells, Peter G
AU  - Wells PG
AD  - Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada; 
      Department of Pharmacology and Toxicology, University of Toronto, Toronto, 
      Ontario M5S 3M2, Canada. Electronic address: pg.wells@utoronto.ca.
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150921
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Teratogens)
RN  - Y4S76JWI15 (Methanol)
SB  - IM
CIN - Reprod Toxicol. 2016 Dec;66:124-125. PMID: 27565515
MH  - Abnormalities, Drug-Induced/*etiology/pathology/physiopathology
MH  - Animals
MH  - Female
MH  - Gestational Age
MH  - Maternal Exposure
MH  - Methanol/*toxicity
MH  - Mice
MH  - Models, Animal
MH  - Osteogenesis/*drug effects
MH  - Pregnancy
MH  - Rabbits
MH  - Rats
MH  - Risk Assessment
MH  - Species Specificity
MH  - Spine/abnormalities/*drug effects/physiopathology
MH  - Teratogens/*toxicity
OTO - NOTNLM
OT  - Methanol (MeOH)
OT  - New Zealand white (NZW) rabbit
OT  - Skeletal development
OT  - Teratology
EDAT- 2015/09/24 06:00
MHDA- 2016/09/27 06:00
CRDT- 2015/09/23 06:00
PHST- 2013/05/28 00:00 [received]
PHST- 2015/07/29 00:00 [revised]
PHST- 2015/09/17 00:00 [accepted]
PHST- 2015/09/23 06:00 [entrez]
PHST- 2015/09/24 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
AID - S0890-6238(15)30022-8 [pii]
AID - 10.1016/j.reprotox.2015.09.004 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2015 Dec;58:104-10. doi: 10.1016/j.reprotox.2015.09.004. Epub 
      2015 Sep 21.