PMID- 26393635
OWN - NLM
STAT- MEDLINE
DCOM- 20160421
LR  - 20220408
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 12
IP  - 9
DP  - 2015 Sep 18
TI  - Association of TCF7L2 Genetic Polymorphisms with Type 2 Diabetes Mellitus in the 
      Uygur Population of China.
PG  - 11797-814
LID - 10.3390/ijerph120911797 [doi]
AB  - BACKGROUND: Genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) 
      gene have been reported to be strongly associated with type 2 diabetes mellitus 
      (T2DM) in Icelandic, Danish and American populations and further replicated in 
      other European populations, African Americans, Mexican Americans, and Asian 
      populations. The aim of the present study was to investigate the association of 
      TCF7L2 gene polymorphisms with T2DM in a Uygur population of China. METHODS: 877 
      T2DM patients and 871 controls were selected for the present study. Two single 
      nucleotide polymorphisms (SNPs) (rs12255372 and rs7901695) were genotyped by 
      using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass 
      spectrometry. The associations of SNPs and haplotypes with T2DM and linkage 
      disequilibrium (LD) structure of the TCF7L2 gene were analyzed. RESULTS: For 
      total participants and male, the distribution of rs12255372 alleles and the 
      dominant model (Guanine Guanine (GG) genotype vs. Guanine Thymine (GT) genotype + 
      Thymine Thymine (TT) genotype) showed significant difference between T2DM and 
      control subjects (for allele: p = 0.013 and p = 0.002, respectively; for dominant 
      model: p = 0.028 and p = 0.008, respectively). The distribution of rs7901695 
      alleles and the dominant model (TT genotype vs. Thymine Cytosine (TC) genotype + 
      Cytosine Cytosine (CC) genotype) for total participants and male showed 
      significant difference between T2DM and control subjects (for allele: both p = 
      0.001; for dominant model: p = 0.006 and p = 0.008, respectively). CONCLUSIONS: 
      Our data suggested that the genetic polymorphisms of the TCF7L2 gene were 
      associated with T2DM in the Uygur population of China.
FAU - Yao, Hua
AU  - Yao H
AD  - Xinjiang Key Laboratory of Metabolic Disease Research, The First Affiliated 
      Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China. 
      yaohua01@sina.com.
FAU - Wang, Zhiqiang
AU  - Wang Z
AD  - Department of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 
      830011, China. zhiqiangwang1987@sina.com.
FAU - Wang, Tingting
AU  - Wang T
AD  - Department of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 
      830011, China. wangtingting2013@sina.com.
FAU - Ma, Yan
AU  - Ma Y
AD  - Department of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 
      830011, China. mayan16@sina.com.
FAU - Su, Yinxia
AU  - Su Y
AD  - Department of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 
      830011, China. yinxia_su@163.com.
FAU - Ma, Qi
AU  - Ma Q
AD  - Xinjiang Key Laboratory of Metabolic Disease Research, The First Affiliated 
      Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China. 
      maqi1212@126.com.
FAU - Wang, Li
AU  - Wang L
AD  - Xinjiang Key Laboratory of Metabolic Disease Research, The First Affiliated 
      Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China. 
      wl78154189@sina.cn.
FAU - Zhu, Jun
AU  - Zhu J
AD  - Xinjiang Key Laboratory of Metabolic Disease Research, The First Affiliated 
      Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China. 
      zhujun6677@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150918
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Adult
MH  - China
MH  - Diabetes Mellitus, Type 2/*ethnology/genetics
MH  - Female
MH  - *Haplotypes
MH  - Humans
MH  - *Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Transcription Factor 7-Like 2 Protein/*genetics/metabolism
PMC - PMC4586708
OTO - NOTNLM
OT  - Case-control study
OT  - Single nucleotide polymorphism
OT  - TCF7L2
OT  - Type 2 diabetes mellitus
EDAT- 2015/09/24 06:00
MHDA- 2016/04/22 06:00
PMCR- 2015/09/01
CRDT- 2015/09/23 06:00
PHST- 2015/07/15 00:00 [received]
PHST- 2015/08/30 00:00 [revised]
PHST- 2015/09/06 00:00 [accepted]
PHST- 2015/09/23 06:00 [entrez]
PHST- 2015/09/24 06:00 [pubmed]
PHST- 2016/04/22 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - ijerph120911797 [pii]
AID - ijerph-12-11797 [pii]
AID - 10.3390/ijerph120911797 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2015 Sep 18;12(9):11797-814. doi: 
      10.3390/ijerph120911797.