PMID- 26393778
OWN - NLM
STAT- MEDLINE
DCOM- 20160822
LR  - 20191210
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 118
DP  - 2015 Sep
TI  - Lifelong consumption of trans fatty acids promotes striatal impairments on 
      Na(+)/K(+) ATPase activity and BDNF mRNA expression in an animal model of mania.
PG  - 78-81
LID - S0361-9230(15)30033-2 [pii]
LID - 10.1016/j.brainresbull.2015.09.005 [doi]
AB  - PURPOSE: To evaluate the toxicity of chronic consumption of processed foods that 
      are rich in trans fat on the lipid composition of brain membranes, as well as its 
      functional repercussions. METHODS: A second generation of male rats born from 
      mothers and grandmothers supplemented with soybean oil (SOC, an isocaloric 
      control group) or hydrogenated vegetable fat (HVF, rich in TFA) (3g/kg; p.o.) 
      were kept under oral treatment until 90 days of age, when they were exposed to an 
      AMPH-induced model of mania. RESULTS: The HVF group presented 0.38% of TFA 
      incorporation in the striatum, affecting Na(+)/K(+) ATPase activity, which was 
      decreased per se and following AMPH-exposure. The HVF group also showed increased 
      protein carbonyl (PC) and brain-derived neurotrophic factor (BDNF) mRNA levels 
      after AMPH administration, while these oxidative and molecular changes were not 
      observed in the other experimental groups. Additionally, a negative correlation 
      between striatal Na(+)/K(+) ATPase activity and PC levels (r(2)=0.49) was 
      observed. CONCLUSION: The prolonged consumption of trans fat allows TFA 
      incorporation and increases striatal oxidative status, thus impairing the 
      functionality of Na(+)/K(+)-ATPase and affecting molecular targets as BDNF mRNA. 
      We hypothesized that the chronic intake of processed foods (rich in TFA) 
      facilitates the development of neuropsychiatric diseases, particularly bipolar 
      disorder.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Dias, Veronica T
AU  - Dias VT
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil.
FAU - Trevizol, Fabiola
AU  - Trevizol F
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil. Electronic address: fatrevizol@yahoo.com.br.
FAU - Barcelos, Raquel C S
AU  - Barcelos RC
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil.
FAU - Kunh, Fabio T
AU  - Kunh FT
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil.
FAU - Roversi, Katiane
AU  - Roversi K
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil.
FAU - Roversi, Karine
AU  - Roversi K
AD  - Departamento de Fisiologia e Farmacologia, UFSM, RS, Brazil.
FAU - Schuster, Alessandra J
AU  - Schuster AJ
AD  - Departamento de Fisiologia e Farmacologia, UFSM, RS, Brazil.
FAU - Pase, Camila S
AU  - Pase CS
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil.
FAU - Golombieski, Ronaldo
AU  - Golombieski R
AD  - Departamento de Ciencias Naturais e Exatas, UFSM, RS, Brazil.
FAU - Emanuelli, Tatiana
AU  - Emanuelli T
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil; Programa de Pos-Graduacao em Ciencia e Tecnologia dos 
      Alimentos, UFSM, RS, Brazil.
FAU - Burger, Marilise E
AU  - Burger ME
AD  - Programa de Pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria 
      (UFSM), RS, Brazil; Programa de Pos-Graduacao em Bioquimica Toxicologica, UFSM, 
      RS, Brazil. Electronic address: mariliseeb@yahoo.com.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150921
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Trans Fatty Acids)
RN  - 8001-22-7 (Soybean Oil)
RN  - CK833KGX7E (Amphetamine)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
SB  - IM
MH  - Amphetamine/pharmacology
MH  - Animals
MH  - Bipolar Disorder/chemically induced/enzymology/genetics/*metabolism
MH  - Brain/drug effects/*metabolism
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/genetics
MH  - Corpus Striatum/drug effects/metabolism
MH  - Diet, High-Fat
MH  - Disease Models, Animal
MH  - Gene Expression
MH  - Male
MH  - Membranes/metabolism
MH  - Motor Activity/drug effects
MH  - Protein Carbonylation
MH  - RNA, Messenger/*biosynthesis/genetics
MH  - Rats
MH  - Sodium-Potassium-Exchanging ATPase/*metabolism
MH  - Soybean Oil/administration & dosage
MH  - Trans Fatty Acids/administration & dosage/metabolism/*toxicity
OTO - NOTNLM
OT  - Amphetamine
OT  - Mania animal model
OT  - Second generation
OT  - Trans fat supplementation
EDAT- 2015/09/24 06:00
MHDA- 2016/08/23 06:00
CRDT- 2015/09/23 06:00
PHST- 2015/05/28 00:00 [received]
PHST- 2015/09/14 00:00 [revised]
PHST- 2015/09/17 00:00 [accepted]
PHST- 2015/09/23 06:00 [entrez]
PHST- 2015/09/24 06:00 [pubmed]
PHST- 2016/08/23 06:00 [medline]
AID - S0361-9230(15)30033-2 [pii]
AID - 10.1016/j.brainresbull.2015.09.005 [doi]
PST - ppublish
SO  - Brain Res Bull. 2015 Sep;118:78-81. doi: 10.1016/j.brainresbull.2015.09.005. Epub 
      2015 Sep 21.