PMID- 26394221
OWN - NLM
STAT- MEDLINE
DCOM- 20160603
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 9
DP  - 2015
TI  - Family Perception and 6-Month Symptomatic and Functioning Outcomes in Young 
      Adolescents at Clinical High Risk for Psychosis in a General Population in China.
PG  - e0138361
LID - 10.1371/journal.pone.0138361 [doi]
LID - e0138361
AB  - BACKGROUND AND AIMS: Given the difficulty of treating schizophrenia and other 
      forms of psychosis, researchers have shifted focus to early detection and 
      intervention of individuals at clinical high risk (CHR) for psychosis. Previous 
      studies have shown that elements in family functioning could predict symptom 
      outcome in CHR individuals. However, associations between self reported family 
      functioning and symptom or functioning outcome of CHR individuals was rarely 
      reported. Our study aimed to investigate the characteristics and the role of 
      family functioning in the development of CHR individuals among young adolescents. 
      METHODS: A sample of 32 CHR individuals was recruited from 2800 university 
      students. The characteristics of family perception were evaluated by both Family 
      Assessment Device (FAD) and Family cohesion and adaptability evaluation Scale II 
      (FACES II). 6 month follow up data was available with 25 of the recruited CHR 
      individuals. Baseline socio-demographic characteristics and family functioning 
      were compared between CHR and control group. We also measured the associations 
      between different dimensions of perceived family functioning and both severity of 
      prodromal symptoms and global functioning at baseline and 6-month follow up. 
      RESULTS: CHR individuals showed more maladaptive family functioning compared to 
      control in nearly all of the dimensions of FAD and FACES II except for Affective 
      Involvement. Better Problem Solving and Affective Responsiveness predicted less 
      severe positive and negative symptoms respectively. Family cohesion and 
      adaptability were not only correlated with the baseline severity of general 
      symptoms, but also positively associated with the general and disorganized 
      symptom outcome. CONCLUSIONS: This study contributed preliminary evidence towards 
      the associations between family perception and symptom outcome of CHR 
      individuals. It also provided evidence for the importance of family interventions 
      on CHR individuals.
FAU - Wang, Lu
AU  - Wang L
AD  - Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Shi, JingYu
AU  - Shi J
AD  - Faculty of Humanities and Behavior Medicine, Tongji University School of 
      Medicine, Shanghai, China.
FAU - Chen, FaZhan
AU  - Chen F
AD  - Department of Psychosomatic Medicine, Tongji Hospital, Tongji University School 
      of Medicine, Shanghai, China.
FAU - Yao, YuHong
AU  - Yao Y
AD  - Department of Tongji university counseling center, Tongji University, Shanghai, 
      China.
FAU - Zhan, ChenYu
AU  - Zhan C
AD  - Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Yin, XiaoWen
AU  - Yin X
AD  - Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Fang, XiaoYan
AU  - Fang X
AD  - Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Wang, HaoJie
AU  - Wang H
AD  - Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Yuan, JiaBei
AU  - Yuan J
AD  - Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Zhao, XuDong
AU  - Zhao X
AD  - Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, China; Faculty of Humanities and Behavior Medicine, 
      Tongji University School of Medicine, Shanghai, China.
LA  - eng
SI  - figshare/10.6084/m9.figshare.1507488
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150922
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - China
MH  - Demography
MH  - Family/*psychology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Psychotic Disorders/*diagnosis/pathology
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Translating
MH  - Young Adult
PMC - PMC4578854
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/09/24 06:00
MHDA- 2016/06/04 06:00
PMCR- 2015/09/22
CRDT- 2015/09/23 06:00
PHST- 2015/04/25 00:00 [received]
PHST- 2015/08/28 00:00 [accepted]
PHST- 2015/09/23 06:00 [entrez]
PHST- 2015/09/24 06:00 [pubmed]
PHST- 2016/06/04 06:00 [medline]
PHST- 2015/09/22 00:00 [pmc-release]
AID - PONE-D-15-17974 [pii]
AID - 10.1371/journal.pone.0138361 [doi]
PST - epublish
SO  - PLoS One. 2015 Sep 22;10(9):e0138361. doi: 10.1371/journal.pone.0138361. 
      eCollection 2015.