PMID- 26395409
OWN - NLM
STAT- MEDLINE
DCOM- 20160914
LR  - 20181202
IS  - 1526-3231 (Electronic)
IS  - 0749-8063 (Linking)
VI  - 32
IP  - 2
DP  - 2016 Feb
TI  - Arthroscopic Bone Marrow Stimulation and Concentrated Bone Marrow Aspirate for 
      Osteochondral Lesions of the Talus: A Case-Control Study of Functional and 
      Magnetic Resonance Observation of Cartilage Repair Tissue Outcomes.
PG  - 339-47
LID - S0749-8063(15)00633-7 [pii]
LID - 10.1016/j.arthro.2015.07.012 [doi]
AB  - PURPOSE: This study compares retrospective functional and magnetic resonance 
      imaging (MRI) outcomes after arthroscopic bone marrow stimulation (BMS) with and 
      without concentrated bone marrow aspirate (cBMA) as a biological adjunct to the 
      surgical treatment of osteochondral lesions (OCLs) of the talus. METHODS: 
      Twenty-two patients who underwent arthroscopic BMS with cBMA (cBMA/BMS group) for 
      an osteochondral lesion (OCL) of the talus and 12 patients who underwent 
      arthroscopic BMS (BMS alone) for an OCL of the talus were retrospectively 
      reviewed. The Foot and Ankle Outcome Score (FAOS) pain subscale and Short Form 12 
      general health questionnaire physical component summary score (SF-12 PCS) 
      provided patient-reported outcome scores pre- and postoperatively. MRI scans were 
      assessed postoperatively using the magnetic resonance observation of cartilage 
      repair tissue (MOCART) score. All patients had postoperative MRI performed at the 
      2-year postoperative visit, and quantitative T2 mapping relaxation time values 
      were assessed in a subset of the cBMA/BMS group. RESULTS: The mean FAOS and SF-12 
      PCS scores improved significantly pre- to post-operatively (P < .01) at a mean 
      follow-up of 48.3 months (range, 34 to 82 months) for the cBMA/BMS group and 77.3 
      months (range, 46 to 100 months) for the BMS-alone group. The MOCART score in the 
      cBMA/BMS group was significantly higher than that in the BMS-alone group (P = 
      .023). Superficial and deep T2 relaxation values in cBMA/BMS patients were higher 
      in repair tissue compared with measurements in adjacent native articular 
      cartilage (P = .030 and P < .001, respectively). CONCLUSIONS: BMS is an effective 
      treatment strategy for treatment of OCLs of the talus and results in good 
      medium-term functional outcomes. Arthroscopic BMS with cBMA also results in 
      similar functional outcomes and improved border repair tissue integration, with 
      less evidence of fissuring and fibrillation on MRI.
CI  - Copyright (c) 2016 Arthroscopy Association of North America. Published by Elsevier 
      Inc. All rights reserved.
FAU - Hannon, Charles P
AU  - Hannon CP
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, 
      Illinois; Department of Foot and Ankle Surgery, Hospital for Special Surgery, New 
      York, New York.
FAU - Ross, Keir A
AU  - Ross KA
AD  - Department of Foot and Ankle Surgery, Hospital for Special Surgery, New York, New 
      York.
FAU - Murawski, Christopher D
AU  - Murawski CD
AD  - Department of Foot and Ankle Surgery, Hospital for Special Surgery, New York, New 
      York; Department of Orthopaedic Surgery, University of Pittsburgh School of 
      Medicine, Pittsburgh, Pennsylvania, U.S.A.
FAU - Deyer, Timothy W
AU  - Deyer TW
AD  - East River Medical Imaging, New York, New York.
FAU - Smyth, Niall A
AU  - Smyth NA
AD  - Department of Foot and Ankle Surgery, Hospital for Special Surgery, New York, New 
      York.
FAU - Hogan, MaCalus V
AU  - Hogan MV
AD  - Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 
      Pittsburgh, Pennsylvania, U.S.A.
FAU - Do, Huong T
AU  - Do HT
AD  - Department of Foot and Ankle Surgery, Hospital for Special Surgery, New York, New 
      York.
FAU - O'Malley, Martin J
AU  - O'Malley MJ
AD  - Department of Foot and Ankle Surgery, Hospital for Special Surgery, New York, New 
      York.
FAU - Kennedy, John G
AU  - Kennedy JG
AD  - Department of Foot and Ankle Surgery, Hospital for Special Surgery, New York, New 
      York. Electronic address: KennedyJ@hss.edu.
LA  - eng
PT  - Journal Article
DEP - 20150926
PL  - United States
TA  - Arthroscopy
JT  - Arthroscopy : the journal of arthroscopic & related surgery : official 
      publication of the Arthroscopy Association of North America and the International 
      Arthroscopy Association
JID - 8506498
SB  - IM
CIN - Arthroscopy. 2016 Feb;32(2):348-9. PMID: 26814396
MH  - *Arthroscopy
MH  - Biopsy, Needle
MH  - Bone Marrow/*physiology
MH  - Cartilage, Articular/pathology/*surgery
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Talus/pathology/*surgery
MH  - Treatment Outcome
MH  - Wound Healing
EDAT- 2015/09/24 06:00
MHDA- 2016/09/15 06:00
CRDT- 2015/09/24 06:00
PHST- 2014/08/24 00:00 [received]
PHST- 2015/07/04 00:00 [revised]
PHST- 2015/07/10 00:00 [accepted]
PHST- 2015/09/24 06:00 [entrez]
PHST- 2015/09/24 06:00 [pubmed]
PHST- 2016/09/15 06:00 [medline]
AID - S0749-8063(15)00633-7 [pii]
AID - 10.1016/j.arthro.2015.07.012 [doi]
PST - ppublish
SO  - Arthroscopy. 2016 Feb;32(2):339-47. doi: 10.1016/j.arthro.2015.07.012. Epub 2015 
      Sep 26.