PMID- 26395442
OWN - NLM
STAT- MEDLINE
DCOM- 20160704
LR  - 20181113
IS  - 1744-9081 (Electronic)
IS  - 1744-9081 (Linking)
VI  - 11
IP  - 1
DP  - 2015 Sep 22
TI  - 4'-O-beta-D-glucosyl-5-O-methylvisamminol, an active ingredient of Saposhnikovia 
      divaricata, attenuates high-mobility group box 1 and subarachnoid 
      hemorrhage-induced vasospasm in a rat model.
PG  - 28
LID - 10.1186/s12993-015-0074-8 [doi]
LID - 28
AB  - BACKGROUND: High-mobility group box 1 (HMGB1) was observed to be an important 
      extracellular mediator involved in vascular inflammation associated with 
      subarachnoid hemorrhage (SAH). This study is of interest to examine the efficacy 
      of 4'-O-beta-D-glucosyl-5-O-methylvisamminol (4OGOMV), C22H28O10, on the alternation 
      of cytokines and HMGB1 in an animal model. METHODS: A rodent double hemorrhage 
      SAH model was employed. Administration with 4OGOMV was initiated 1 h after 
      animals were subjected to SAH. Basilar arteries (BAs) were harvested and cortexes 
      examined for HMGB1 mRNA, protein expression (Western blot) and monocyte 
      chemoattractant protein-1 (MCP-1) immunostaining. Cerebrospinal fluid samples 
      were collected to examine IL-1beta, IL-6, IL-8 and MCP-1 (rt-PCR). RESULTS: 
      Morphological findings revealed endothelial cell deformity, intravascular elastic 
      lamina torture, and smooth muscle necrosis in the vessels of SAH groups. 
      Correspondently, IL-1beta, IL-6 and MCP-1 in the SAH-only and SAH-plus vehicle 
      groups was also elevated. 4OGOMV dose-dependently reduced HMGB1 protein 
      expression when compared with the SAH groups.(p < 0.01) Likewise, 400 mug/kg 
      4OGOMV reduced IL-1beta, MCP-1 and HMGB1 mRNA levels as well as MCP-1(+) monocytes 
      when compared with the SAH groups.. CONCLUSION: 4OGOMV exerts its 
      neuro-protective effect partly through the dual effect of inhibiting IL-6 and 
      MCP-1 activation and also reduced HMGB1 protein, mRNA and MCP-1(+) leukocytes 
      translocation. This study lends credence to validating 4OGOMV as able to 
      attenuate pro-inflammatory cytokine mRNA, late-onset inflammasome, and cellular 
      basis in SAH-induced vasospasm.
FAU - Chang, Chih-Zen
AU  - Chang CZ
AD  - Department of Surgery, Faculty of Medicine, School of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan. changchihzen2002@yahoo.com.tw.
AD  - Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University 
      Hospital, No.100, Tzyou 1st Road, Kaohsiung, Taiwan, ROC. 
      changchihzen2002@yahoo.com.tw.
AD  - Department of Surgery, Kaohsiung Municipal Ta Tung Hospital, Kaohsiung, Taiwan. 
      changchihzen2002@yahoo.com.tw.
FAU - Wu, Shu-Chuan
AU  - Wu SC
AD  - Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University 
      Hospital, No.100, Tzyou 1st Road, Kaohsiung, Taiwan, ROC. shuchuan@kmu.edu.tw.
FAU - Kwan, Aij-Lie
AU  - Kwan AL
AD  - Department of Surgery, Faculty of Medicine, School of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan. A_LKWAN@yahoo.com.
AD  - Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University 
      Hospital, No.100, Tzyou 1st Road, Kaohsiung, Taiwan, ROC. A_LKWAN@yahoo.com.
FAU - Lin, Chih-Lung
AU  - Lin CL
AD  - Department of Surgery, Faculty of Medicine, School of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan. chihlung1@yahoo.com.
AD  - Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University 
      Hospital, No.100, Tzyou 1st Road, Kaohsiung, Taiwan, ROC. chihlung1@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20150922
PL  - England
TA  - Behav Brain Funct
JT  - Behavioral and brain functions : BBF
JID - 101245751
RN  - 0 (4'-O-glucosyl-5-O-methylvisamminol)
RN  - 0 (Chromones)
RN  - 0 (Cytokines)
RN  - 0 (Glucosides)
RN  - 0 (HMGB1 Protein)
RN  - 0 (Hbp1 protein, rat)
RN  - 0 (Neuroprotective Agents)
RN  - EC 3.4.22.- (Caspase 3)
RN  - EC 3.4.22.- (Caspase 9)
SB  - IM
MH  - Animals
MH  - Apiaceae/*chemistry
MH  - Caspase 3/metabolism
MH  - Caspase 9/metabolism
MH  - Cell Movement/drug effects
MH  - Chromones/pharmacology/*therapeutic use
MH  - Cytokines/cerebrospinal fluid
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Glucosides/pharmacology/*therapeutic use
MH  - HMGB1 Protein/*biosynthesis
MH  - Leukocytes/drug effects
MH  - Male
MH  - Neuroprotective Agents/pharmacology/therapeutic use
MH  - Rats
MH  - Subarachnoid Hemorrhage/complications/*drug therapy/metabolism/pathology
MH  - Vasospasm, Intracranial/complications/*drug therapy/metabolism/pathology
PMC - PMC4578329
EDAT- 2015/09/24 06:00
MHDA- 2016/07/05 06:00
PMCR- 2015/09/22
CRDT- 2015/09/24 06:00
PHST- 2015/01/21 00:00 [received]
PHST- 2015/09/11 00:00 [accepted]
PHST- 2015/09/24 06:00 [entrez]
PHST- 2015/09/24 06:00 [pubmed]
PHST- 2016/07/05 06:00 [medline]
PHST- 2015/09/22 00:00 [pmc-release]
AID - 10.1186/s12993-015-0074-8 [pii]
AID - 74 [pii]
AID - 10.1186/s12993-015-0074-8 [doi]
PST - epublish
SO  - Behav Brain Funct. 2015 Sep 22;11(1):28. doi: 10.1186/s12993-015-0074-8.