PMID- 26395671
OWN - NLM
STAT- MEDLINE
DCOM- 20160303
LR  - 20181113
IS  - 1748-880X (Electronic)
IS  - 0007-1285 (Print)
IS  - 0007-1285 (Linking)
VI  - 88
IP  - 1056
DP  - 2015
TI  - Dosimetric planning study for the prevention of anal complications after 
      post-operative whole pelvic radiotherapy in cervical cancer patients with 
      hemorrhoids.
PG  - 20150223
LID - 10.1259/bjr.20150223 [doi]
LID - 20150223
AB  - OBJECTIVE: Radiation-induced anal toxicity can be induced by low radiation doses 
      in patients with haemorrhoids. The object of this study was to determine the 
      dosimetric benefits of different whole pelvic radiotherapy (WPRT) techniques in 
      terms of dose delivered to the anal canal in post-operative patients with 
      cervical cancer. METHODS: The planning CT images of 10 patients with cervical 
      cancer undergoing postoperative radiotherapy were used for comparison of three 
      different plans. All patients had been treated using the conventional box 
      technique WPRT (CV-WPRT), and we tried low-margin-modified WPRT (LM-WPRT), 
      three-dimensional conformal techniques WPRT (CF-WPRT) and intensity-modulated 
      WPRT (IM-WPRT) planning for dosimetric comparison of the anal canal, 
      retrospectively. RESULTS: Mean anal canal doses of the IM-WPRT were significantly 
      lower (p < 0.05) than those of CV-WPRT, LM-WPRT and CF-WPRT, and V10, V20, V30 
      and V40 to the anal canal were also significantly lower for IM-WPRT (p < 0.05). 
      The proportion of planning target volumes (PTVs) that received >/=98% of the 
      prescribed dose for all plans was >99%, and the proportion that received >/=108% of 
      the prescribed dose for IM-WPRT was <2%. Volumes of bladders and rectums that 
      received >/=30 or >/=40 Gy were significantly lower for IM-WPRT than for three of the 
      four-field WPRT plans (p = 0.000). CONCLUSION: IM-WPRT can significantly reduce 
      radiation dose delivered to the anal canal and does not compromise PTV coverage. 
      In patients with haemorrhoids, IM-WPRT may be of value for the prevention of anal 
      complications. ADVANCES IN KNOWLEDGE: Although tolerance of the anal canal tends 
      to be ignored in patients undergoing post-operative WPRT, patients with 
      haemorrhoids may suffer complications at low radiation doses. The present study 
      shows IM-WPRT can be meaningful in these patients.
FAU - Baek, J G
AU  - Baek JG
AD  - 1 Department of Radiation Oncology, Dongguk University Gyeongju Hospital, 
      Gyeongju, Republic of Korea.
AD  - 2 Department of Physics, Yeungnam University, Gyeongsan, Republic of Korea.
FAU - Kim, E C
AU  - Kim EC
AD  - 2 Department of Physics, Yeungnam University, Gyeongsan, Republic of Korea.
FAU - Kim, S K
AU  - Kim SK
AD  - 3 Department of Radiation Oncology, Yeungnam University College of Medicine, 
      Daegu, Republic of Korea.
FAU - Jang, H
AU  - Jang H
AD  - 1 Department of Radiation Oncology, Dongguk University Gyeongju Hospital, 
      Gyeongju, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20150923
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anal Canal/*radiation effects
MH  - Female
MH  - Hemorrhoids/*complications
MH  - Humans
MH  - Middle Aged
MH  - Pelvis/radiation effects
MH  - Radiation Injuries/prevention & control
MH  - *Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Uterine Cervical Neoplasms/*complications/*radiotherapy
PMC - PMC4984930
EDAT- 2015/09/24 06:00
MHDA- 2016/03/05 06:00
PMCR- 2016/12/01
CRDT- 2015/09/24 06:00
PHST- 2015/09/24 06:00 [entrez]
PHST- 2015/09/24 06:00 [pubmed]
PHST- 2016/03/05 06:00 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - 10.1259/bjr.20150223 [doi]
PST - ppublish
SO  - Br J Radiol. 2015;88(1056):20150223. doi: 10.1259/bjr.20150223. Epub 2015 Sep 23.