PMID- 26397829 OWN - NLM STAT- MEDLINE DCOM- 20160523 LR - 20150924 IS - 1678-2690 (Electronic) IS - 0001-3765 (Linking) VI - 87 IP - 2 Suppl DP - 2015 Aug TI - Effects of omega-3 supplementation on interleukin and neurotrophin levels in an animal model of schizophrenia. PG - 1475-86 LID - S0001-37652015000301475 [pii] LID - 10.1590/0001-3765201520140714 [doi] AB - New studies suggest that polyunsaturated fatty acids, such as omega-3, may reduce the symptoms of schizophrenia. The present study evaluated the preventive effect of omega-3 on interleukines (IL) and neurotrophin brain-derived neurotrophic factor (BDNF) levels in the brains of young rats subjected to a model of schizophrenia. Treatment was performed over 21 days, starting on the 30th day of rat's life. After 14 days of treatment with omega-3 or vehicle, a concomitant treatment with saline or ketamine (25 mg/kg) was started and maintained until the last day of the experiment. BDNF levels in the rat's prefrontal cortex were decreased at 1 h and 24 h after the last administration of ketamine, whereas the group administered with ketamine and omega-3 showed a decrease in BDNF levels only after 24 h. In contrast, both interventions induced similar responses in levels of IL-1beta and IL6. These findings suggest that the similarity of IL-1beta and IL6 levels in our experimental groups is due to the mechanism of action of ketamine on the immune system. More studies have to be carried out to explain this pathology. In conclusion, according to previous studies and considering the current study, we could suggest a prophylactic role of omega-3 against the outcome of symptoms associated with schizophrenia. FAU - Zugno, Alexandra I AU - Zugno AI AD - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR. FAU - Canever, Lara AU - Canever L AD - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR. FAU - Mastella, Gustavo AU - Mastella G AD - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR. FAU - Heylmann, Alexandra S AU - Heylmann AS AD - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR. FAU - Oliveira, Mariana B AU - Oliveira MB AD - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR. FAU - Steckert, Amanda V AU - Steckert AV AD - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR. FAU - Castro, Adalberto A AU - Castro AA AD - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR. FAU - dal Pizzol, Felipe AU - dal Pizzol F AD - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR. FAU - Quevedo, Joao AU - Quevedo J AD - Universidade do Extremo Sul Catarinense, Criciuma, SC, BR. FAU - Gama, Clarissa S AU - Gama CS AD - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BR. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Brazil TA - An Acad Bras Cienc JT - Anais da Academia Brasileira de Ciencias JID - 7503280 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Fatty Acids, Omega-3) RN - 0 (Interleukins) RN - 690G0D6V8H (Ketamine) SB - IM MH - Animals MH - *Brain Chemistry MH - Brain-Derived Neurotrophic Factor/*analysis/drug effects MH - *Dietary Supplements MH - Disease Models, Animal MH - Fatty Acids, Omega-3/*administration & dosage MH - Interleukins/*analysis MH - Ketamine/*administration & dosage MH - Male MH - Rats MH - Rats, Wistar MH - Schizophrenia/*prevention & control EDAT- 2015/09/24 06:00 MHDA- 2016/05/24 06:00 CRDT- 2015/09/24 06:00 PHST- 2015/09/24 06:00 [entrez] PHST- 2015/09/24 06:00 [pubmed] PHST- 2016/05/24 06:00 [medline] AID - S0001-37652015000301475 [pii] AID - 10.1590/0001-3765201520140714 [doi] PST - ppublish SO - An Acad Bras Cienc. 2015 Aug;87(2 Suppl):1475-86. doi: 10.1590/0001-3765201520140714.