PMID- 26398594
OWN - NLM
STAT- Publisher
LR  - 20220331
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 17
IP  - 5
DP  - 2016 May 1
TI  - Electrical Intramuscular Stimulation in Osteoarthritis Enhances the Inhibitory 
      Systems in Pain Processing at Cortical and Cortical Spinal System.
PG  - 877-891
LID - 10.1111/pme.12930 [doi]
AB  - OBJECTIVE: To determine if in knee osteoarthritis (KOA), one session of active 
      electrical intramuscular stimulation (a-EIMS) compared with sham causes an effect 
      on the motor cortex excitability parameters [motor evoked potential (MEP; the 
      primary outcome), short intracortical inhibition (SICI), intracortical 
      facilitation (ICF) and cortical silent period (CSP)] and pain measurements [pain 
      pressure threshold (PPT); visual analog scale (VAS) and change in numerical pain 
      scale (NPS(0-10) ) during the conditioned pain modulation (CPM)-task]. This study 
      also set out to determine if serum brain-derived neurotrophic factor (BDNF) 
      mediates the effect of treatment on the cortical spinal system as assessed by MEP 
      and PPT. DESIGN: Randomized clinical trial. SUBJECTS AND METHODS: Women with KOA, 
      50-75-years old received a 30-min session of either sham (n = 13) or a-EIMS 
      (n = 13) with 2 Hz. The pain measures and excitability parameters were measured 
      before and immediately after a-EIMS or sham. RESULTS: The a-EIMS group compared 
      with sham decreased the MEP by 31,67% [confidence interval (CI) 95%, 2.34-60.98]. 
      For the secondary outcomes, the a-EIMS reduced the ICF and increased the CSP but 
      not changed the SICI. The a-EIMS improved the pain reported on VAS, the PPT, and 
      the score of the NPS (0-10) during the CPM-task The BDNF was negatively 
      correlated with the PPT (r = -0.56). CONCLUSIONS: The serum BDNF revealed an 
      inverse relationship with PPT independent of the treatment group. These results 
      suggest that a-EIMS enhanced the corticospinal inhibitory systems in cortical and 
      infracortical pain processing sites most likely by bottom-up regulation 
      mechanisms.
CI  - Wiley Periodicals, Inc.
FAU - da Graca-Tarrago, Maria
AU  - da Graca-Tarrago M
AD  - Post-Graduate Program in Medical Sciences, School of Medicine, Universidade 
      Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil.
AD  - Laboratory of Pain and Neuromodulation at HCPA, Porto Alegre, Brazil.
FAU - Deitos, Alicia
AU  - Deitos A
AD  - Post-Graduate Program in Medical Sciences, School of Medicine, Universidade 
      Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil.
AD  - Laboratory of Pain and Neuromodulation at HCPA, Porto Alegre, Brazil.
FAU - Patricia Brietzke, Aline
AU  - Patricia Brietzke A
AD  - Post-Graduate Program in Medical Sciences, School of Medicine, Universidade 
      Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil.
AD  - Laboratory of Pain and Neuromodulation at HCPA, Porto Alegre, Brazil.
FAU - Torres, Iraci L S
AU  - Torres IL
AD  - Post-Graduate Program in Medical Sciences, School of Medicine, Universidade 
      Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil.
AD  - Pharmacology Department, Instituto De Ciencias Basicas Da Saude, UFRGS, Porto 
      Alegre, Brazil.
FAU - Cadore Stefani, Luciana
AU  - Cadore Stefani L
AD  - Post-Graduate Program in Medical Sciences, School of Medicine, Universidade 
      Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil.
AD  - Laboratory of Pain and Neuromodulation at HCPA, Porto Alegre, Brazil.
AD  - Surgery Department, School of Medicine at UFRGS, Porto Alegre, Brazil.
AD  - Anesthesia and Perioperative Pain Medicine at Hospital De Clinicas De Porto 
      Alegre (HCPA), Porto Alegre, Brazil.
FAU - Fregni, Felipe
AU  - Fregni F
AD  - Department of Physical Medicine and Rehabilitation Boston, Harvard Medical 
      School, Boston, Massachusetts, USA.
FAU - Caumo, Wolnei
AU  - Caumo W
AD  - Post-Graduate Program in Medical Sciences, School of Medicine, Universidade 
      Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil.
AD  - Laboratory of Pain and Neuromodulation at HCPA, Porto Alegre, Brazil.
AD  - Surgery Department, School of Medicine at UFRGS, Porto Alegre, Brazil.
AD  - Pain and Palliative Care Service at Hospital De Clinicas De Porto Alegre (HCPA), 
      Porto Alegre, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20150923
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
OTO - NOTNLM
OT  - Brain-Derived Neurotrophic Factor
OT  - Conditioned Pain Modulation
OT  - Intramuscular Stimulation
OT  - Osteoarthritis
OT  - Pain Pressure Threshold
OT  - Transcranial Magnetic Stimulation
EDAT- 2015/09/24 06:00
MHDA- 2015/09/24 06:00
CRDT- 2015/09/24 06:00
PHST- 2015/05/04 00:00 [received]
PHST- 2015/08/13 00:00 [revised]
PHST- 2015/08/16 00:00 [accepted]
PHST- 2015/09/24 06:00 [entrez]
PHST- 2015/09/24 06:00 [pubmed]
PHST- 2015/09/24 06:00 [medline]
AID - 10.1111/pme.12930 [doi]
PST - ppublish
SO  - Pain Med. 2016 May 1;17(5):877-891. doi: 10.1111/pme.12930. Epub 2015 Sep 23.