PMID- 26399502
OWN - NLM
STAT- MEDLINE
DCOM- 20160707
LR  - 20181113
IS  - 1477-7819 (Electronic)
IS  - 1477-7819 (Linking)
VI  - 13
DP  - 2015 Sep 24
TI  - The role of primary surgical treatment in young patients with squamous cell 
      carcinoma of the larynx: a 20-year review of 34 cases.
PG  - 283
LID - 10.1186/s12957-015-0699-y [doi]
LID - 283
AB  - BACKGROUND: The aim of this study was to investigate the clinical patterns in 
      young Chinese patients (less than 40 years old) with laryngeal squamous cell 
      cancer (LSCC) and the outcome of primary open surgery. METHODS: Thirty-four young 
      patients, with histologically confirmed LSCC between 1985 and 2005 at Qilu 
      Hospital and Affiliated Hospital of Weifang Medical College, who underwent 
      primary open surgery were retrospectively evaluated according to the clinical 
      patterns in comparison with 374 non-young patients (older than 40 years). The 
      Kaplan-Meier method was used to calculate the survival rate. The relevance of 
      smoking, tumor location, tumor-node-metastasis (TNM) staging, lymph node 
      involvement, tumor size, and histological differentiation to overall survival was 
      tested by multivariate analysis. RESULTS: There was a significantly higher rate 
      of smoking (p = 0.020) in the non-young patients compared to the young patients, 
      but no significant difference was observed in alcohol consumption, tumor 
      location, tumor size, TNM staging, lymph node metastasis, histological grade, and 
      5-year overall survival. One-year survival rates were 100%, 3-year survival rates 
      were 79.41%, and 5-year survival rates were 67.65%. In the multivariate analysis, 
      lymph node involvement (p = 0.006), tumor stage (p = 0.022), and tumor size 
      (p = 0.004) proved to be significant predictors of overall survival. CONCLUSIONS: 
      The incidence of smoking was significantly higher in non-young patients compared 
      to young patients. Primary surgery with or without radiotherapy may provide a 
      value treatment option for young LSCC. Nodal status, tumor stage, and tumor size 
      were the primary determinants of overall survival in multivariate analysis. These 
      data may provide useful information for counseling and treatment planning.
FAU - Wang, Junxi
AU  - Wang J
AD  - Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of 
      Weifang Medical College, 2428 Yunhe Road, Weifang, 261031, Shandong, People's 
      Republic China. wangjunxisdl@163.com.
FAU - Zhao, Xingguo
AU  - Zhao X
AD  - Department of Otolaryngology-Head and Neck Surgery, Qilu Hospital, Shandong 
      University, Jinan, 107#, Wenhua Xi Road, Jinan, Shandong, 250012, People's 
      Republic of China. zhaoxingguo@126.com.
FAU - Pan, Xinliang
AU  - Pan X
AD  - Department of Otolaryngology-Head and Neck Surgery, Qilu Hospital, Shandong 
      University, Jinan, 107#, Wenhua Xi Road, Jinan, Shandong, 250012, People's 
      Republic of China. panxinliang@yahoo.com.cn.
FAU - Zhao, Limin
AU  - Zhao L
AD  - Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of 
      Weifang Medical College, 2428 Yunhe Road, Weifang, 261031, Shandong, People's 
      Republic China. zhaolimin@163.comp.
FAU - Zhou, Jianming
AU  - Zhou J
AD  - Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of 
      Weifang Medical College, 2428 Yunhe Road, Weifang, 261031, Shandong, People's 
      Republic China. zhoujiangming@163.com.
FAU - Ji, Min
AU  - Ji M
AD  - Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of 
      Weifang Medical College, 2428 Yunhe Road, Weifang, 261031, Shandong, People's 
      Republic China. Jimin@126.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20150924
PL  - England
TA  - World J Surg Oncol
JT  - World journal of surgical oncology
JID - 101170544
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/mortality/pathology/*surgery
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Laryngeal Neoplasms/mortality/pathology/*surgery
MH  - *Laryngectomy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Young Adult
PMC - PMC4581450
EDAT- 2015/09/25 06:00
MHDA- 2016/07/09 06:00
PMCR- 2015/09/24
CRDT- 2015/09/25 06:00
PHST- 2015/05/12 00:00 [received]
PHST- 2015/09/14 00:00 [accepted]
PHST- 2015/09/25 06:00 [entrez]
PHST- 2015/09/25 06:00 [pubmed]
PHST- 2016/07/09 06:00 [medline]
PHST- 2015/09/24 00:00 [pmc-release]
AID - 10.1186/s12957-015-0699-y [pii]
AID - 699 [pii]
AID - 10.1186/s12957-015-0699-y [doi]
PST - epublish
SO  - World J Surg Oncol. 2015 Sep 24;13:283. doi: 10.1186/s12957-015-0699-y.