PMID- 26399764
OWN - NLM
STAT- MEDLINE
DCOM- 20160811
LR  - 20220311
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 79
IP  - 11
DP  - 2015
TI  - Risk stratification of coronary artery disease in asymptomatic diabetic subjects 
      using multidetector computed tomography.
PG  - 2422-9
LID - 10.1253/circj.CJ-15-0325 [doi]
AB  - BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) show a greater risk for 
      coronary artery disease (CAD), but the risk stratification in asymptomatic CAD 
      patients has not been established. This study investigated the prevalence and 
      severity for asymptomatic CAD and predictors in T2DM patients. 
      METHODS AND RESULTS: In a multiclinic group, diabetic patients (320 men, 186 
      women) without known symptoms suggestive of CAD were recruited for multidetector 
      computed tomography (MDCT). Patients were categorized according to severity of 
      coronary atherosclerosis: Grade 1 (normal findings), Grade 2 (mild 
      atherosclerosis without significant stenosis), Grade 3 (moderate 
      stenosis/atherosclerosis, 50-74% stenosis), Grade 4 (moderate 
      stenosis/atherosclerosis, 75-89% stenosis), Grade 5 (severe 
      stenosis/atherosclerosis, >/=90% stenosis). The trend for severity grade of CAD was 
      slightly higher in men than women (P=0.054). For critical lesions (combined 
      Grades 3-5), the prevalence was almost equal (men 44% vs. women 37%; P=0.113). 
      Multivariate models showed that in men, HbA1c>/=7.4%, dyslipidemia, duration of 
      diabetes, retinopathy, and other type of cardiovascular diseases were predictors 
      of critical lesions and in women, duration of diabetes and retinopathy were 
      predictors. CONCLUSIONS: The prevalence and severity of asymptomatic CAD are 
      comparably high in men and women with T2DM. Risk stratification by using MDCT 
      might be useful to predict asymptomatic coronary lesions requiring coronary 
      revascularization.
FAU - Shimabukuro, Michio
AU  - Shimabukuro M
AD  - Department of Cardio-Diabetes Medicine, Institute of Biomedical Sciences, 
      Tokushima University Graduate School.
FAU - Saito, Taro
AU  - Saito T
FAU - Higa, Toru
AU  - Higa T
FAU - Nakamura, Keita
AU  - Nakamura K
FAU - Masuzaki, Hiroaki
AU  - Masuzaki H
FAU - Sata, Masataka
AU  - Sata M
CN  - Fukuoka diabetologists group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150918
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
SB  - IM
CIN - Circ J. 2016;80(2):543. PMID: 26781269
CIN - Circ J. 2016;80(2):544. PMID: 26781270
MH  - Aged
MH  - Asymptomatic Diseases
MH  - Comorbidity
MH  - Coronary Angiography/*methods
MH  - Coronary Artery Disease/*diagnostic imaging/epidemiology
MH  - Coronary Stenosis/*diagnostic imaging/epidemiology
MH  - Coronary Vessels/*diagnostic imaging
MH  - Diabetes Mellitus, Type 2/diagnosis/*epidemiology
MH  - Diabetic Angiopathies/*diagnostic imaging/epidemiology
MH  - Female
MH  - Humans
MH  - Japan/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - *Multidetector Computed Tomography
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
EDAT- 2015/09/25 06:00
MHDA- 2016/08/12 06:00
CRDT- 2015/09/25 06:00
PHST- 2015/09/25 06:00 [entrez]
PHST- 2015/09/25 06:00 [pubmed]
PHST- 2016/08/12 06:00 [medline]
AID - 10.1253/circj.CJ-15-0325 [doi]
PST - ppublish
SO  - Circ J. 2015;79(11):2422-9. doi: 10.1253/circj.CJ-15-0325. Epub 2015 Sep 18.