PMID- 26399965
OWN - NLM
STAT- MEDLINE
DCOM- 20161006
LR  - 20181113
IS  - 2150-5608 (Electronic)
IS  - 2150-5594 (Print)
IS  - 2150-5594 (Linking)
VI  - 6
IP  - 8
DP  - 2015
TI  - Antibodies to P-selectin glycoprotein ligand-1 block dendritic cell-mediated 
      enterovirus 71 transmission and prevent virus-induced cells death.
PG  - 802-8
LID - 10.1080/21505594.2015.1094605 [doi]
AB  - P-selectin glycoprotein ligand-1 (PSGL-1) has been proved to serve as the 
      functional receptor for enterovirus 71 (EV71). We found the abundant expression 
      of PSGL-1 on monocyte-derived dendritic cells (MDDCs). However, we have 
      previously demonstrated that MDDCs did not support efficient replication of EV71. 
      Dendritic cells (DCs) have been described to be subverted by various viruses 
      including EV71 for viral dissemination, we thus explore the potential 
      contribution of PSGL-1 on DC-mediated EV71 transmission. We found that the 
      cell-surface-expressing PSGL-1 on MDDCs mediated EV71 binding, and intriguingly, 
      these loaded-viruses on MDDCs could be transferred to encountered target cells; 
      Prior-treatment with PSGL-1 antibodies or interference with PSGL-1 expression 
      diminished MDDC-mediated EV71 transfer and rescued virus-induced cell death. Our 
      data uncover a novel role of PSGL-1 in DC-mediated EV71 spread, and provide an 
      insight into blocking primary EV71 infection.
FAU - Ren, Xiao-Xin
AU  - Ren XX
AD  - a Jiangsu Key Laboratory of Infection and Immunity; Institutes of Biology and 
      Medical Sciences; Soochow University ; Suzhou , China.
AD  - b Key Laboratory of Molecular Virology and Immunology; Institute Pasteur of 
      Shanghai; Chinese Academy of Sciences ; Shanghai , China.
FAU - Li, Chuan
AU  - Li C
AD  - b Key Laboratory of Molecular Virology and Immunology; Institute Pasteur of 
      Shanghai; Chinese Academy of Sciences ; Shanghai , China.
FAU - Xiong, Si-Dong
AU  - Xiong SD
AD  - a Jiangsu Key Laboratory of Infection and Immunity; Institutes of Biology and 
      Medical Sciences; Soochow University ; Suzhou , China.
FAU - Huang, Zhong
AU  - Huang Z
AD  - b Key Laboratory of Molecular Virology and Immunology; Institute Pasteur of 
      Shanghai; Chinese Academy of Sciences ; Shanghai , China.
FAU - Wang, Jian-Hua
AU  - Wang JH
AD  - b Key Laboratory of Molecular Virology and Immunology; Institute Pasteur of 
      Shanghai; Chinese Academy of Sciences ; Shanghai , China.
FAU - Wang, Hai-Bo
AU  - Wang HB
AD  - b Key Laboratory of Molecular Virology and Immunology; Institute Pasteur of 
      Shanghai; Chinese Academy of Sciences ; Shanghai , China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150923
PL  - United States
TA  - Virulence
JT  - Virulence
JID - 101531386
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (P-selectin ligand protein)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Receptors, Virus)
SB  - IM
MH  - Antibodies, Monoclonal/immunology/*pharmacology
MH  - Cell Death/immunology
MH  - Cell Line
MH  - Dendritic Cells/*drug effects/immunology/*virology
MH  - Enterovirus A, Human/*drug effects/metabolism
MH  - Flow Cytometry
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Jurkat Cells
MH  - Membrane Glycoproteins/*immunology/metabolism
MH  - RNA, Small Interfering
MH  - Receptors, Virus/metabolism
MH  - Virus Attachment/drug effects
PMC - PMC4826143
OTO - NOTNLM
OT  - Dendritic cell
OT  - P-selectin glycoprotein ligand-1
OT  - enterovirus 71
OT  - viral transmission
EDAT- 2015/09/25 06:00
MHDA- 2016/10/08 06:00
PMCR- 2016/09/23
CRDT- 2015/09/25 06:00
PHST- 2015/09/25 06:00 [entrez]
PHST- 2015/09/25 06:00 [pubmed]
PHST- 2016/10/08 06:00 [medline]
PHST- 2016/09/23 00:00 [pmc-release]
AID - 1094605 [pii]
AID - 10.1080/21505594.2015.1094605 [doi]
PST - ppublish
SO  - Virulence. 2015;6(8):802-8. doi: 10.1080/21505594.2015.1094605. Epub 2015 Sep 23.