PMID- 26400435
OWN - NLM
STAT- MEDLINE
DCOM- 20160706
LR  - 20181113
IS  - 1541-1087 (Electronic)
IS  - 0731-5724 (Print)
IS  - 0731-5724 (Linking)
VI  - 34 Suppl 1
IP  - 0 1
DP  - 2015
TI  - Mitigation of Inflammation-Induced Mood Dysregulation by Long-Chain Omega-3 Fatty 
      Acids.
PG  - 48-55
LID - 10.1080/07315724.2015.1080527 [doi]
AB  - Although evidence suggests that chronic elevations in immune-inflammatory 
      signaling can precipitate mood symptoms in a subset of individuals, associated 
      risk and resilience mechanisms remain poorly understood. Long-chain omega-3 
      (LCn-3) fatty acids, including eicosapentaenic acid (EPA) and docosahexaenoic 
      acid (DHA), have anti-inflammatory and inflammation-resolving properties that 
      maintain immune-inflammatory signaling homeostasis. Cross-sectional evidence 
      suggests that the mood disorders major depressive disorder and bipolar disorder 
      are associated with low EPA and/or DHA biostatus, elevations in the LCn-6:LCn-3 
      fatty acid ratio, and elevated levels of pro-inflammatory eicosanoids, cytokines, 
      and acute-phase proteins. Medications that are effective for reducing depressive 
      symptoms or stabilizing manic depressive oscillations may act in part by 
      downregulating immune-inflammatory signaling and are augmented by 
      anti-inflammatory medications. Recent prospective longitudinal evidence suggests 
      that elevations in the LCn-6:LCn-3 fatty acid ratio are a modifiable risk factor 
      for the development of mood symptoms, including depression and irritability, in 
      response to immune-inflammatory signaling. Together these data suggest that 
      increasing LCn-3 fatty acid intake and biostatus represents a feasible strategy 
      to mitigate the negative impact of elevated immune-inflammatory signaling on mood 
      stability. Key teaching points: * Long-chain omega-3 (LCn-3) fatty acids have 
      anti-inflammatory and inflammation-resolving properties. * Major mood disorders 
      are associated with both LCn-3 fatty acids deficiency and elevated 
      immune-inflammatory signaling. * Prospective evidence suggests that low LCn-3 
      fatty acid biostatus increases risk for developing inflammation-induced mood 
      dysregulation. * Taken collectively, this evidence suggests that increasing LCn-3 
      fatty acid intake and biostatus represents a promising strategy to mitigate the 
      detrimental effects of elevated immune-inflammatory signaling on mood.
FAU - McNamara, Robert K
AU  - McNamara RK
AD  - a Department of Psychiatry and Behavioral Neuroscience , Division of Bipolar 
      Disorders Research, University of Cincinnati College of Medicine , Cincinnati , 
      Ohio.
LA  - eng
GR  - R01 DK097599/DK/NIDDK NIH HHS/United States
GR  - DK097599/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Am Coll Nutr
JT  - Journal of the American College of Nutrition
JID - 8215879
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
SB  - IM
MH  - Acute-Phase Proteins/metabolism
MH  - Affect
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Cross-Sectional Studies
MH  - Cytokines/metabolism
MH  - Docosahexaenoic Acids/*pharmacology
MH  - Eicosapentaenoic Acid/*pharmacology
MH  - Humans
MH  - Inflammation/*complications/immunology
MH  - Mood Disorders/*drug therapy/etiology/immunology
MH  - Prospective Studies
MH  - Risk Factors
MH  - Signal Transduction/drug effects
PMC - PMC4686371
MID - NIHMS744732
OTO - NOTNLM
OT  - arachidonic acid
OT  - bipolar disorder
OT  - cytokines
OT  - depression
OT  - docosahexaenoic acid (DHA)
OT  - inflammation
OT  - mood
OT  - omega-3 fatty acids
EDAT- 2015/09/25 06:00
MHDA- 2016/07/07 06:00
PMCR- 2016/01/01
CRDT- 2015/09/25 06:00
PHST- 2015/09/25 06:00 [entrez]
PHST- 2015/09/25 06:00 [pubmed]
PHST- 2016/07/07 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.1080/07315724.2015.1080527 [doi]
PST - ppublish
SO  - J Am Coll Nutr. 2015;34 Suppl 1(0 1):48-55. doi: 10.1080/07315724.2015.1080527.