PMID- 26400882
OWN - NLM
STAT- MEDLINE
DCOM- 20160401
LR  - 20181202
IS  - 1732-2693 (Electronic)
IS  - 0032-5449 (Linking)
VI  - 69
DP  - 2015 Aug 19
TI  - [The impact of chromatin modification on the development of chronic complications 
      in patients with diabetes].
PG  - 964-8
LID - 10.5604/17322693.1165198 [doi]
AB  - Diabetes is a chronic, metabolic disease. Over 347 million people worldwide have 
      diabetes. Chronic complications (retinopathy, nephropathy or neuropathy) are the 
      major dangerous outcome of this disease. Recent studies indicate a significant 
      role of epigenetic regulation in the development of chronic complications in 
      patients with diabetes. Hyperglycemia could cause abnormal regulation of the 
      activity of enzymes participating in the post-translational histone modifications 
      (PTHMs) and initiation of changes in patterns of DNA methylation. It leads to 
      modification of chromatin structure. These epigenetic abnormalities result in 
      changes in the expression of genes involved in development of chronic 
      inflammation, such as NF-KAPPAB (nuclear factor kappaB gene), TNFalpha (tumor 
      necrosis factor a gene), IL6 (interleukin 6 gene) or MCP1 (monocyte 
      chemoattractant protein 1 gene). It enhances endothelial cell dysfunction, which 
      plays an important role in development of chronic, diabetic complications. In 
      addition, caused by hyperglycemia epigenetic modifications changes in structure 
      of chromatin explains "metabolic memory", a phenomenon of presence of 
      pathological pathways related to the prolonged hyperglycemia in the past, despite 
      maintaining good metabolic control later on.
FAU - Wegner, Malgorzata
AU  - Wegner M
AD  - Pracownia Metabolizmu Lipidow, Katedra Chemii i Biochemii Klinicznej Uniwersytetu 
      Medycznego im. K. Marcinkowskiego w Poznaniu.
FAU - Piorunska-Stolzmann, Maria
AU  - Piorunska-Stolzmann M
AD  - Zaklad Biochemii Klinicznej i Medycyny Laboratoryjnej, Katedra Chemii i Biochemii 
      Klinicznej Uniwersytetu Medycznego im. K. Marcinkowskiego w Poznaniu.
FAU - Jagodzinski, Pawel P
AU  - Jagodzinski PP
AD  - Katedra i Zaklad Biochemii i Biologii Molekularnej Uniwersytetu Medycznego im. K. 
      Marcinkowskiego w Poznaniu.
LA  - pol
PT  - Journal Article
PT  - Review
TT  - Wplyw modyfikacji struktury chromatyny na rozwoj przewleklych powiklan 
      cukrzycowych.
DEP - 20150819
PL  - Poland
TA  - Postepy Hig Med Dosw (Online)
JT  - Postepy higieny i medycyny doswiadczalnej (Online)
JID - 101206517
RN  - 0 (Chromatin)
SB  - IM
MH  - Chromatin/*metabolism
MH  - Diabetes Complications/*physiopathology
MH  - Diabetes Mellitus/*metabolism
MH  - Endothelial Cells/*metabolism
MH  - Epigenesis, Genetic/*physiology
MH  - Humans
EDAT- 2015/09/25 06:00
MHDA- 2016/04/02 06:00
CRDT- 2015/09/25 06:00
PHST- 2015/09/25 06:00 [entrez]
PHST- 2015/09/25 06:00 [pubmed]
PHST- 2016/04/02 06:00 [medline]
AID - 1165198 [pii]
AID - 10.5604/17322693.1165198 [doi]
PST - epublish
SO  - Postepy Hig Med Dosw (Online). 2015 Aug 19;69:964-8. doi: 
      10.5604/17322693.1165198.