PMID- 26401760
OWN - NLM
STAT- MEDLINE
DCOM- 20160729
LR  - 20221207
IS  - 1744-8042 (Electronic)
IS  - 1462-2416 (Linking)
VI  - 16
IP  - 14
DP  - 2015
TI  - BDNF (Val66Met) genetic polymorphism is associated with vulnerability for 
      methamphetamine dependence.
PG  - 1541-5
LID - 10.2217/pgs.15.96 [doi]
AB  - AIM: Association of the brain-derived neurotrophic factor (BDNF) genetic 
      polymorphism rs6265 (Val66Met) with methamphetamine (METH) dependence and 
      METH-induced psychosis was investigated in the Thai population. MATERIALS & 
      METHODS: The rs6265 genotype was determined in 100 male METH-dependent subjects 
      and 102 controls using a real-time PCR high-resolution melt (RT-PCR-HRM) assay. 
      RESULTS: The rs6265 genotype demonstrated significant differences in distribution 
      between METH-dependent subjects and controls in which the frequency of GG 
      genotype versus A-allele carriers was associated with METH dependence. Moreover, 
      a significant effect of genotype on the occurrence of psychosis was found, with a 
      lower frequency of GG genotype associated with METH-induced psychosis. 
      CONCLUSION: The present findings indicate that rs6265 is associated with METH 
      dependence in the Thai population, with the GG genotype greater in METH-dependent 
      subjects but reducing the emergence of METH-dependent psychosis.
FAU - Iamjan, Sri-Arun
AU  - Iamjan SA
AD  - Department of Anatomy, Faculty of Medical Science, Naresuan University, 
      Phitsanulok 65000, Thailand.
AD  - Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, 
      Naresuan University, Phitsanulok 65000, Thailand.
FAU - Thanoi, Samur
AU  - Thanoi S
AD  - Department of Anatomy, Faculty of Medical Science, Naresuan University, 
      Phitsanulok 65000, Thailand.
AD  - Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, 
      Naresuan University, Phitsanulok 65000, Thailand.
FAU - Watiktinkorn, Paritat
AU  - Watiktinkorn P
AD  - Synphaet Hospital, Bangkok, Thailand.
FAU - Nudmamud-Thanoi, Sutisa
AU  - Nudmamud-Thanoi S
AD  - Department of Anatomy, Faculty of Medical Science, Naresuan University, 
      Phitsanulok 65000, Thailand.
AD  - Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, 
      Naresuan University, Phitsanulok 65000, Thailand.
FAU - Reynolds, Gavin P
AU  - Reynolds GP
AD  - Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, 
      Naresuan University, Phitsanulok 65000, Thailand.
AD  - Biomedical Research Centre, Sheffield Hallam University, Sheffield, S1 1WB, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150924
PL  - England
TA  - Pharmacogenomics
JT  - Pharmacogenomics
JID - 100897350
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Amphetamine-Related Disorders/epidemiology/*genetics
MH  - Asian People/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - *Central Nervous System Stimulants
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - *Methamphetamine
MH  - Polymorphism, Genetic/*genetics
MH  - Psychoses, Substance-Induced/epidemiology/genetics
MH  - Thailand/epidemiology
OTO - NOTNLM
OT  - BDNF
OT  - methamphetamine dependence
OT  - polymorphism
OT  - psychosis
OT  - rs6265
EDAT- 2015/09/25 06:00
MHDA- 2016/07/30 06:00
CRDT- 2015/09/25 06:00
PHST- 2015/09/25 06:00 [entrez]
PHST- 2015/09/25 06:00 [pubmed]
PHST- 2016/07/30 06:00 [medline]
AID - 10.2217/pgs.15.96 [doi]
PST - ppublish
SO  - Pharmacogenomics. 2015;16(14):1541-5. doi: 10.2217/pgs.15.96. Epub 2015 Sep 24.