PMID- 26402095
OWN - NLM
STAT- MEDLINE
DCOM- 20160803
LR  - 20151031
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 48
IP  - 4
DP  - 2015
TI  - sAbetaPPalpha Improves Hippocampal NMDA-Dependent Functional Alterations Linked to 
      Healthy Aging.
PG  - 927-35
LID - 10.3233/JAD-150297 [doi]
AB  - This study shows a decrease in soluble amyloid-beta protein precursor-alpha (sAbetaPPalpha) 
      levels, but no change in sAbetaPPbeta, in the rat hippocampus during healthy aging, 
      associated with the weaker expression of N-methyl-D-aspartate receptor 
      (NMDAR)-dependent long-term potentiation (LTP) in the CA1 area of hippocampal 
      slices. Exogenous application of recombinant sAbetaPPalpha increases NMDAR activation in 
      aged animals and could rescue the age-related LTP deficits described. In 
      contrast, it does not affect basal synaptic transmission or glutamate release. 
      These results indicate that improving synaptic sAbetaPPalpha availability at synapses 
      helps in reducing the functional NMDAR-related deregulation of hippocampal 
      networks linked to aging.
FAU - Moreno, Laura
AU  - Moreno L
FAU - Rose, Christiane
AU  - Rose C
FAU - Mohanraj, Arun
AU  - Mohanraj A
FAU - Allinquant, Bernadette
AU  - Allinquant B
FAU - Billard, Jean-Marie
AU  - Billard JM
FAU - Dutar, Patrick
AU  - Dutar P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Recombinant Proteins)
RN  - EC 3.4.- (Amyloid Precursor Protein Secretases)
SB  - IM
MH  - Aging/*physiology
MH  - Amyloid Precursor Protein Secretases/metabolism
MH  - Amyloid beta-Protein Precursor/administration & dosage/*metabolism
MH  - Animals
MH  - Blotting, Western
MH  - Electric Stimulation
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Excitatory Postsynaptic Potentials/physiology
MH  - Hippocampus/*physiology
MH  - Long-Term Potentiation/*physiology
MH  - Microelectrodes
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Recombinant Proteins/administration & dosage/metabolism
MH  - Tissue Culture Techniques
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - NMDA receptors
OT  - amyloid-beta protein precursor
OT  - glutamate
OT  - memory
OT  - mouse hippocampus
OT  - synaptic plasticity
OT  - alpha-secretase
EDAT- 2015/09/25 06:00
MHDA- 2016/08/04 06:00
CRDT- 2015/09/25 06:00
PHST- 2015/09/25 06:00 [entrez]
PHST- 2015/09/25 06:00 [pubmed]
PHST- 2016/08/04 06:00 [medline]
AID - JAD150297 [pii]
AID - 10.3233/JAD-150297 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2015;48(4):927-35. doi: 10.3233/JAD-150297.