PMID- 26402757
OWN - NLM
STAT- MEDLINE
DCOM- 20160628
LR  - 20161125
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 47
IP  - 1
DP  - 2015
TI  - Decreased Serum IGF-1/IGFBP-3 Molar Ratio is Associated with Executive Function 
      Behaviors in Type 2 Diabetic Patients with Mild Cognitive Impairment.
PG  - 85-94
LID - 10.3233/JAD-150071 [doi]
AB  - BACKGROUND: Insulin-like growth factor (IGF)-1, through insulin/IGF-1 signaling 
      pathway, is involved in the pathogenesis of type 2 diabetes mellitus (T2DM) and 
      Alzheimer's disease. OBJECTIVE: This study aimed to assess the association of 
      serum IGF-1 and IGF binding protein (IGFBP)-3 levels with cognition status and to 
      determine whether IGF-1 rs972936 polymorphism is associated with T2DM with mild 
      cognitive impairment (MCI). METHODS: A total of 150 T2DM patients, 75 satisfying 
      the MCI diagnostic criteria and 75 exhibiting healthy cognition, were enrolled in 
      this study. The cognitive function of the subjects was extensively assessed. 
      Serum IGF-1 and IGFBP-3 levels were measured through enzyme-linked immunosorbent 
      assay; IGF-1/IGFBP-3 molar ratio was calculated. Single nucleotide polymorphisms 
      of the IGF-1-(rs972936) gene were analyzed. RESULTS: Serum IGF-1/IGFBP-3 molar 
      ratio in MCI patients was significantly lower than that in the control group 
      (p = 0.003). Significant negative correlations were found between IGF-1/IGFBP-3 
      molar ratio and Trail Making Test A and B (TMT-A and TMT-B) scores (p = 0.003; 
      p <  0.001, respectively), which indicated executive function. Further multiple 
      step-wise regression analysis revealed that the TMT-A or TMT-B score was 
      significantly associated only with serum IGF-1/IGFBP-3 molar ratio (p = 0.016; 
      p <  0.001, respectively). No significant difference was found in the genotype or 
      allele distribution of IGF-1 rs972936 polymorphism between MCI and control 
      groups. CONCLUSIONS: A low serum IGF-1/IGFBP-3 molar ratio is associated with the 
      pathogenesis of MCI, particularly executive function in T2DM populations. Further 
      investigation with a large population size should be conducted to confirm this 
      observed association.
FAU - Huang, Rong
AU  - Huang R
AD  - Medical School of Southeast University, Nanjing, PR China; Department of 
      Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, PR 
      China.
FAU - Wang, Pin
AU  - Wang P
AD  - Medical School of Southeast University, Nanjing, PR China.
FAU - Han, Jing
AU  - Han J
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, PR China.
FAU - Xia, Wenqing
AU  - Xia W
AD  - Medical School of Southeast University, Nanjing, PR China.
FAU - Cai, Rongrong
AU  - Cai R
AD  - Medical School of Southeast University, Nanjing, PR China.
FAU - Sun, Haixia
AU  - Sun H
AD  - Medical School of Southeast University, Nanjing, PR China.
FAU - Sun, Jie
AU  - Sun J
AD  - Medical School of Southeast University, Nanjing, PR China.
FAU - Wang, Shaohua
AU  - Wang S
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
EIN - J Alzheimers Dis. 2015;48(3):875. PMID: 26445161
MH  - Aged
MH  - Cognitive Dysfunction/*blood/*complications
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Executive Function/*physiology
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/genetics/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Statistics, Nonparametric
OTO - NOTNLM
OT  - Insulin-like growth factor-1
OT  - mild cognitive impairment
OT  - polymorphism
OT  - type 2 diabetes mellitus
EDAT- 2015/09/25 06:00
MHDA- 2016/06/29 06:00
CRDT- 2015/09/25 06:00
PHST- 2015/09/25 06:00 [entrez]
PHST- 2015/09/25 06:00 [pubmed]
PHST- 2016/06/29 06:00 [medline]
AID - JAD150071 [pii]
AID - 10.3233/JAD-150071 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2015;47(1):85-94. doi: 10.3233/JAD-150071.