PMID- 26402922 OWN - NLM STAT- MEDLINE DCOM- 20170117 LR - 20240521 IS - 1873-2054 (Electronic) IS - 1353-8292 (Print) IS - 1353-8292 (Linking) VI - 35 DP - 2015 Sep TI - The impact of environmental and climatic variation on the spatiotemporal trends of hospitalized pediatric diarrhea in Ho Chi Minh City, Vietnam. PG - 147-54 LID - S1353-8292(15)00109-4 [pii] LID - 10.1016/j.healthplace.2015.08.001 [doi] AB - It is predicted that the integration of climate-based early warning systems into existing action plans will facilitate the timely provision of interventions to diarrheal disease epidemics in resource-poor settings. Diarrhea remains a considerable public health problem in Ho Chi Minh City (HCMC), Vietnam and we aimed to quantify variation in the impact of environmental conditions on diarrheal disease risk across the city. Using all inpatient diarrheal admissions data from three large hospitals within HCMC, we developed a mixed effects regression model to differentiate district-level variation in risk due to environmental conditions from the overarching seasonality of diarrheal disease hospitalization in HCMC. We identified considerable spatial heterogeneity in the risk of all-cause diarrhea across districts of HCMC with low elevation and differential responses to flooding, air temperature, and humidity driving further spatial heterogeneity in diarrheal disease risk. The incorporation of these results into predictive forecasting algorithms will provide a powerful resource to aid diarrheal disease prevention and control practices in HCMC and other similar settings. CI - Copyright (c) 2015 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Thompson, Corinne N AU - Thompson CN AD - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, United Kingdom; The London School of Hygiene & Tropical Medicine, United Kingdom. Electronic address: cthompson@oucru.org. FAU - Zelner, Jonathan L AU - Zelner JL AD - Robert Wood Johnson Foundation Health and Society Scholars Program, 701A Knox Hall, Columbia University, New York, NY 10027, USA. Electronic address: jlz2115@columbia.edu. FAU - Nhu, Tran Do Hoang AU - Nhu Tdo H AD - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam. Electronic address: nhutdh@oucru.org. FAU - Phan, My Vt AU - Phan MV AD - Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom. Electronic address: mp21@sanger.ac.uk. FAU - Hoang Le, Phuc AU - Hoang Le P AD - Children's Hospital 1, Ho Chi Minh City, Vietnam. Electronic address: drphuc.ph1@gmail.com. FAU - Nguyen Thanh, Hung AU - Nguyen Thanh H AD - Children's Hospital 1, Ho Chi Minh City, Vietnam. Electronic address: hungnt@oucru.org. FAU - Vu Thuy, Duong AU - Vu Thuy D AD - Children's Hospital 1, Ho Chi Minh City, Vietnam. Electronic address: duongvt@oucru.org. FAU - Minh Nguyen, Ngoc AU - Minh Nguyen N AD - Children's Hospital 2, Ho Chi Minh City, Vietnam. Electronic address: mngocnd2@yahoo.com. FAU - Ha Manh, Tuan AU - Ha Manh T AD - Children's Hospital 2, Ho Chi Minh City, Vietnam. Electronic address: manhtuanzu@yahoo.com. FAU - Van Hoang Minh, Tu AU - Van Hoang Minh T AD - Children's Hospital 2, Ho Chi Minh City, Vietnam. Electronic address: vanhmt@oucru.org. FAU - Lu Lan, Vi AU - Lu Lan V AD - Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. Electronic address: drluvi@yahoo.com.vn. FAU - Nguyen Van Vinh, Chau AU - Nguyen Van Vinh C AD - Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. Electronic address: chaunvv@oucru.org. FAU - Tran Tinh, Hien AU - Tran Tinh H AD - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, United Kingdom. Electronic address: hientt@oucru.org. FAU - von Clemm, Emmiliese AU - von Clemm E AD - Department of Ecology and Evolutionary Biology, Princeton University, NJ, USA. Electronic address: emmiliese.von.clemm@gmail.com. FAU - Storch, Harry AU - Storch H AD - Brandenburg University of Technology, Cottbus, Germany. Electronic address: harry.storch@gmail.com. FAU - Thwaites, Guy AU - Thwaites G AD - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, United Kingdom. Electronic address: gthwaites@oucru.org. FAU - Grenfell, Bryan T AU - Grenfell BT AD - Department of Ecology and Evolutionary Biology, Princeton University, NJ, USA; RAPIDD Program, Fogarty International Center, National Institutes of Health, Bethesda, MD, USA. Electronic address: grenfell@princeton.edu. FAU - Baker, Stephen AU - Baker S AD - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, United Kingdom; The London School of Hygiene & Tropical Medicine, United Kingdom. Electronic address: sbaker@oucru.org. LA - eng GR - 100087/Wellcome Trust/United Kingdom GR - WT1093824/Wellcome Trust/United Kingdom GR - 089276/Wellcome Trust/United Kingdom GR - 100087/Z/12/Z/Wellcome Trust/United Kingdom GR - P2C HD047879/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20150922 PL - England TA - Health Place JT - Health & place JID - 9510067 MH - Child MH - Diarrhea/*epidemiology MH - *Environment MH - Female MH - Hospitals, Pediatric MH - Humans MH - Male MH - *Seasons MH - Vietnam/epidemiology PMC - PMC4664115 OTO - NOTNLM OT - Climate change OT - Diarrhea OT - Environment OT - Mixed effects OT - Spatial risk EDAT- 2015/09/25 06:00 MHDA- 2017/01/18 06:00 PMCR- 2015/09/01 CRDT- 2015/09/25 06:00 PHST- 2015/04/13 00:00 [received] PHST- 2015/07/21 00:00 [revised] PHST- 2015/08/02 00:00 [accepted] PHST- 2015/09/25 06:00 [entrez] PHST- 2015/09/25 06:00 [pubmed] PHST- 2017/01/18 06:00 [medline] PHST- 2015/09/01 00:00 [pmc-release] AID - S1353-8292(15)00109-4 [pii] AID - 10.1016/j.healthplace.2015.08.001 [doi] PST - ppublish SO - Health Place. 2015 Sep;35:147-54. doi: 10.1016/j.healthplace.2015.08.001. Epub 2015 Sep 22.