PMID- 26403366
OWN - NLM
STAT- MEDLINE
DCOM- 20160809
LR  - 20151102
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 24
IP  - 11
DP  - 2015 Nov
TI  - Intracranial versus Extracranial Symptomatic Carotid Atherosclerosis in Chinese 
      Patients: Risk Factors, Stroke Mechanisms, and Long-Term Prognosis.
PG  - 2632-9
LID - S1052-3057(15)00422-X [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2015.07.019 [doi]
AB  - OBJECTIVES: This study aims to investigate the clinical-radiological features and 
      stroke mechanisms of symptomatic intracranial internal carotid artery (IICA) 
      atherosclerosis and prognoses of patients with IICA atherosclosis, and compare 
      these data with those from patients with symptomatic extranial carotid artery 
      (EICA) atherosclerosis. METHODS: We prospectively recruited 155 patients with 
      symptomatic IICA or EICA atherosclerosis (stenosis >/=50% or occlusion) from 1968 
      Chinese patients with a first-ever ischemic stroke or transient ischemic attack. 
      The patients were followed up for stroke recurrence, cardiovascular events, and 
      death. RESULTS: There were 80 and 75 patients in the IICA and EICA groups, 
      respectively. Multivariate logistic regression analyses showed that the patients 
      in the IICA group were associated with hypertension (odds ratio [OR], 5.980; 95% 
      confidence interval [CI], 1.790-19.976) and asymptomatic intracranial 
      atherosclerosis (OR, 2.564; 95% CI, 1.222-5.377), while the patients in the EICA 
      group were associated with smoking (OR, 2.397; 95% CI, 1.150-4.998) and 
      contralateral EICA disease (OR, 4.742; 95% CI, 1.455-15.455). Hemodynamic stroke 
      alone was more common in the IICA group; artery-to-artery embolism was identified 
      more often in the EICA group (P <.05). The cumulative incidences of ipsilateral 
      stroke recurrence, stroke recurrence and cardiovascular events, and death at 5 
      years were 43.5%, 52.4%, and 27.3%, respectively, in the patients of the IICA 
      group, which did not differ from those of the EICA group. CONCLUSIONS: IICA 
      atherosclerosis as well as EICA atherosclerosis is an important cause of stroke 
      in Chinese patients. Patients with symptomatic IICA atherosclerosis had unique 
      clinical-radiological features and stroke mechanisms compared with those with 
      symptomatic EICA atherosclerosis; their long-term prognosis was poor.
CI  - Copyright (c) 2015 National Stroke Association. Published by Elsevier Inc. All 
      rights reserved.
FAU - Chen, Hongbing
AU  - Chen H
AD  - Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun 
      Yat-Sen University, Guangzhou, China.
FAU - Hong, Hua
AU  - Hong H
AD  - Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun 
      Yat-Sen University, Guangzhou, China.
FAU - Xing, Shihui
AU  - Xing S
AD  - Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun 
      Yat-Sen University, Guangzhou, China.
FAU - Liu, Gang
AU  - Liu G
AD  - Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun 
      Yat-Sen University, Guangzhou, China.
FAU - Zhang, Aiwu
AU  - Zhang A
AD  - Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun 
      Yat-Sen University, Guangzhou, China.
FAU - Tan, Shuangquan
AU  - Tan S
AD  - Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun 
      Yat-Sen University, Guangzhou, China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun 
      Yat-Sen University, Guangzhou, China.
FAU - Zeng, Jinsheng
AU  - Zeng J
AD  - Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun 
      Yat-Sen University, Guangzhou, China. Electronic address: 
      zengjs@pub.guangzhou.gd.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150926
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/pathology
MH  - Carotid Artery Diseases/*complications
MH  - Carotid Artery, External/*pathology
MH  - Carotid Artery, Internal/*pathology
MH  - China
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Longitudinal Studies
MH  - Magnetic Resonance Angiography
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Risk Factors
MH  - Statistics, Nonparametric
MH  - Stroke/*complications
OTO - NOTNLM
OT  - Internal carotid artery
OT  - atherosclerosis
OT  - prognosis
OT  - risk factor
OT  - stroke mechanisms
OT  - stroke recurrence
EDAT- 2015/09/26 06:00
MHDA- 2016/08/10 06:00
CRDT- 2015/09/26 06:00
PHST- 2015/04/16 00:00 [received]
PHST- 2015/06/24 00:00 [revised]
PHST- 2015/07/24 00:00 [accepted]
PHST- 2015/09/26 06:00 [entrez]
PHST- 2015/09/26 06:00 [pubmed]
PHST- 2016/08/10 06:00 [medline]
AID - S1052-3057(15)00422-X [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2015.07.019 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2015 Nov;24(11):2632-9. doi: 
      10.1016/j.jstrokecerebrovasdis.2015.07.019. Epub 2015 Sep 26.