PMID- 26405456 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150925 LR - 20200930 IS - 1744-859X (Print) IS - 1744-859X (Electronic) IS - 1744-859X (Linking) VI - 14 DP - 2015 TI - The relationship between brain-derived neurotrophic factor and cognitive functions in alcohol-dependent patients: a preliminary study. PG - 30 LID - 10.1186/s12991-015-0065-z [doi] LID - 30 AB - BACKGROUND: As a neurotoxic substance, alcohol can induce neurodegenesis in the brain. Alcohol-dependent patients' cognitive functioning can be affected by chronic alcohol use. In addition, brain-derived neurotrophic factor (BDNF) is known to reflect the status of neuroadaptive changes. The purpose of this study was to investigate the relationship between cognitive functions and BDNF in alcohol-dependent patients. METHODS: The subjects were 39 alcohol-dependent patients. BDNF was measured using an enzyme-linked immunosorbent assay kit. We examined clinical features and administered the Korean version of Alcohol Dependence Scale. We also used the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) to measure cognitive functioning. Then, we determined the relationships between BDNF and various parts of the CERAD. RESULTS: The performance of alcohol-dependent patients proved stable in most parts of the CERAD. Within the different parts of the CERAD, only Trail Making Test B correlated with BDNF. Trail Making Test specifically assesses executive functions. CONCLUSIONS: BDNF might play an important role in the detection of neurocognitive function among individuals with alcohol dependence. FAU - Han, Changwoo AU - Han C AD - Department of Psychiatry, College of Medicine, Korea University, Ansan Hospital, Ansan, Korea. FAU - Bae, Hwallip AU - Bae H AD - Department of Psychiatry, Seonam University, Myongji Hospital, Goyang, Korea. FAU - Won, Sung-Doo AU - Won SD AD - Keyo Medical Foundation, Keyo Hospital, Uiwang, Korea. FAU - Roh, Sungwon AU - Roh S AD - Department of Mental Health Research, Seoul National Hospital, Seoul, Korea. FAU - Kim, Dai-Jin AU - Kim DJ AD - Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, 137-701 Korea. LA - eng PT - Journal Article DEP - 20150923 PL - England TA - Ann Gen Psychiatry JT - Annals of general psychiatry JID - 101236515 PMC - PMC4581104 OTO - NOTNLM OT - Alcohol dependence OT - Brain-derived neurotrophic factor OT - Cognitive function EDAT- 2015/09/26 06:00 MHDA- 2015/09/26 06:01 PMCR- 2015/09/23 CRDT- 2015/09/26 06:00 PHST- 2015/03/04 00:00 [received] PHST- 2015/09/08 00:00 [accepted] PHST- 2015/09/26 06:00 [entrez] PHST- 2015/09/26 06:00 [pubmed] PHST- 2015/09/26 06:01 [medline] PHST- 2015/09/23 00:00 [pmc-release] AID - 65 [pii] AID - 10.1186/s12991-015-0065-z [doi] PST - epublish SO - Ann Gen Psychiatry. 2015 Sep 23;14:30. doi: 10.1186/s12991-015-0065-z. eCollection 2015.