PMID- 26407757
OWN - NLM
STAT- MEDLINE
DCOM- 20170110
LR  - 20200830
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Linking)
VI  - 51
DP  - 2016 Jan
TI  - Interaction of BDNF with cytokines in chronic schizophrenia.
PG  - 169-175
LID - S0889-1591(15)30021-0 [pii]
LID - 10.1016/j.bbi.2015.09.014 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) interacts with cytokines. Although both 
      BDNF and cytokines occur at abnormal levels in schizophrenia patients, their 
      interactions have not yet been examined. We therefore compared serum BDNF, TNF-alpha, 
      interleukin (IL)-2, IL-6, and IL-8 levels in 92 chronically medicated 
      schizophrenia patients and 60 healthy controls. We correlated these serum levels 
      within these subject groups with each other and with clinical symptoms assessed 
      according to the Positive and Negative Syndrome Scale (PANSS). Compared to the 
      control group, the schizophrenia patients had significantly lower BDNF and TNF-alpha 
      levels, and higher IL-2, IL-6, and IL-8 levels. The patients also showed a 
      significant positive correlation between BDNF and both IL-2 and IL-8 levels, and 
      low BDNF and TNF-alpha levels together were associated with poor performance on the 
      PANSS cognitive factor. Thus, an interaction between cytokines and neurotrophic 
      factors may be implicated in the pathophysiology of chronic schizophrenia. In 
      particular, the cytokine TNF-alpha may interact with BNDF causing cognitive 
      impairment.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Zhang, Xiang Yang
AU  - Zhang XY
AD  - Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, 
      Beijing, China; Department of Psychiatry and Behavioral Sciences, The University 
      of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: 
      xiang.y.zhang@uth.tmc.edu.
FAU - Tan, Yun-Long
AU  - Tan YL
AD  - Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, 
      Beijing, China.
FAU - Chen, Da-Chun
AU  - Chen DC
AD  - Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, 
      Beijing, China.
FAU - Tan, Shu-Ping
AU  - Tan SP
AD  - Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, 
      Beijing, China.
FAU - Yang, Fu-De
AU  - Yang FD
AD  - Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, 
      Beijing, China.
FAU - Wu, Hanjing Emily
AU  - Wu HE
AD  - Department of Psychiatry and Behavioral Sciences, The University of Texas Health 
      Science Center at Houston, Houston, TX, USA.
FAU - Zunta-Soares, Giovana B
AU  - Zunta-Soares GB
AD  - Department of Psychiatry and Behavioral Sciences, The University of Texas Health 
      Science Center at Houston, Houston, TX, USA.
FAU - Huang, Xu-Feng
AU  - Huang XF
AD  - Centre for Translational Neuroscience, School of Medicine, University of 
      Wollongong, and Illawarra Health and Medical Research Institute, NSW, Australia.
FAU - Kosten, Thomas R
AU  - Kosten TR
AD  - Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 
      Houston, TX, USA.
FAU - Soares, Jair C
AU  - Soares JC
AD  - Department of Psychiatry and Behavioral Sciences, The University of Texas Health 
      Science Center at Houston, Houston, TX, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150925
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Interleukin-2/blood
MH  - Interleukin-6/blood
MH  - Interleukin-8/blood
MH  - Male
MH  - Middle Aged
MH  - Schizophrenia/*blood/complications/drug therapy
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - BDNF
OT  - Cognition
OT  - Cytokine
OT  - Interaction
OT  - Schizophrenia
OT  - Symptom
EDAT- 2015/09/27 06:00
MHDA- 2017/01/11 06:00
CRDT- 2015/09/27 06:00
PHST- 2015/03/23 00:00 [received]
PHST- 2015/09/21 00:00 [revised]
PHST- 2015/09/22 00:00 [accepted]
PHST- 2015/09/27 06:00 [entrez]
PHST- 2015/09/27 06:00 [pubmed]
PHST- 2017/01/11 06:00 [medline]
AID - S0889-1591(15)30021-0 [pii]
AID - 10.1016/j.bbi.2015.09.014 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2016 Jan;51:169-175. doi: 10.1016/j.bbi.2015.09.014. Epub 2015 
      Sep 25.