PMID- 26408071
OWN - NLM
STAT- MEDLINE
DCOM- 20160809
LR  - 20181113
IS  - 1873-7528 (Electronic)
IS  - 0149-7634 (Print)
IS  - 0149-7634 (Linking)
VI  - 57
DP  - 2015 Oct
TI  - The prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA): Controlled 
      studies in humans and laboratory animals.
PG  - 433-46
LID - S0149-7634(15)30083-X [pii]
LID - 10.1016/j.neubiorev.2015.08.016 [doi]
AB  - Users of +/-3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy') report prosocial 
      effects such as sociability and empathy. Supporting these apparently unique 
      social effects, data from controlled laboratory studies indicate that MDMA alters 
      social feelings, information processing, and behavior in humans, and social 
      behavior in rodents. Here, we review this growing body of evidence. In rodents, 
      MDMA increases passive prosocial behavior (adjacent lying) and social reward 
      while decreasing aggression, effects that may involve serotonin 1A receptor 
      mediated oxytocin release interacting with vasopressin receptor 1A. In humans, 
      MDMA increases plasma oxytocin and produces feelings of social affiliation. It 
      decreases identification of negative facial expressions (cognitive empathy) and 
      blunts responses to social rejection, while enhancing responses to others' 
      positive emotions (emotional empathy) and increasing social approach. Thus, 
      consistent with drug folklore, laboratory administration of MDMA robustly alters 
      social processing in humans and increases social approach in humans and animals. 
      Effects are consistent with increased sociability, with mixed evidence about 
      enhanced empathy. These neurobiologically-complex prosocial effects likely 
      motivate recreational ecstasy use.
CI  - Copyright (c) 2015. Published by Elsevier Ltd.
FAU - Kamilar-Britt, Philip
AU  - Kamilar-Britt P
AD  - Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside 
      Drive, MC 120, New York, NY 10032, United States. Electronic address: 
      kabritt@nyspi.columbia.edu.
FAU - Bedi, Gillinder
AU  - Bedi G
AD  - Division on Substance Abuse, New York State Psychiatric Institute, Department of 
      Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 
      Riverside Drive, MC 120, New York, NY 10032, United States. Electronic address: 
      gb2326@columbia.edu.
LA  - eng
GR  - K23 DA034877/DA/NIDA NIH HHS/United States
GR  - R03 DA029679/DA/NIDA NIH HHS/United States
GR  - DA029679/DA/NIDA NIH HHS/United States
GR  - DA034877/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20150925
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Interpersonal Relations
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - *Social Behavior
PMC - PMC4678620
MID - NIHMS742238
OTO - NOTNLM
OT  - Ecstasy
OT  - Empathy
OT  - MDMA
OT  - Molly
OT  - Prosocial
OT  - Sociability
OT  - Social reward
OT  - Social threat
EDAT- 2015/09/27 06:00
MHDA- 2016/08/10 06:00
PMCR- 2016/10/01
CRDT- 2015/09/27 06:00
PHST- 2015/07/13 00:00 [received]
PHST- 2015/08/26 00:00 [revised]
PHST- 2015/08/28 00:00 [accepted]
PHST- 2015/09/27 06:00 [entrez]
PHST- 2015/09/27 06:00 [pubmed]
PHST- 2016/08/10 06:00 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - S0149-7634(15)30083-X [pii]
AID - 10.1016/j.neubiorev.2015.08.016 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2015 Oct;57:433-46. doi: 10.1016/j.neubiorev.2015.08.016. 
      Epub 2015 Sep 25.