PMID- 26408987
OWN - NLM
STAT- MEDLINE
DCOM- 20160815
LR  - 20221207
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 310
DP  - 2015 Dec 3
TI  - Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, 
      and biochemical aberrations caused by chronic restraint stress.
PG  - 561-77
LID - S0306-4522(15)00852-0 [pii]
LID - 10.1016/j.neuroscience.2015.09.033 [doi]
AB  - Increasing numbers of studies have suggested that the gut microbiota is involved 
      in the pathophysiology of stress-related disorders. Chronic stress can cause 
      behavioral, cognitive, biochemical, and gut microbiota aberrations. Gut bacteria 
      can communicate with the host through the microbiota-gut-brain axis (which mainly 
      includes the immune, neuroendocrine, and neural pathways) to influence brain and 
      behavior. It is hypothesized that administration of probiotics can improve 
      chronic-stress-induced depression. In order to examine this hypothesis, the 
      chronic restraint stress depression model was established in this study. Adult 
      specific pathogen free (SPF) Sprague-Dawley rats were subjected to 21 days of 
      restraint stress followed by behavioral testing (including the sucrose preference 
      test (SPT), elevated-plus maze test, open-field test (OFT), object recognition 
      test (ORT), and object placement test (OPT)) and biochemical analysis. 
      Supplemental Lactobacillus helveticus NS8 was provided every day during stress 
      until the end of experiment, and selective serotonin reuptake inhibitor (SSRI) 
      citalopram (CIT) served as a positive control. Results showed that L. helveticus 
      NS8 improved chronic restraint stress-induced behavioral (anxiety and depression) 
      and cognitive dysfunction, showing an effect similar to and better than that of 
      CIT. L. helveticus NS8 also resulted in lower plasma corticosterone (CORT) and 
      adrenocorticotropic hormone (ACTH) levels, higher plasma interleukin-10 (IL-10) 
      levels, restored hippocampal serotonin (5-HT) and norepinephrine (NE) levels, and 
      more hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression than in 
      chronic stress rats. Taken together, these results indicate an anti-depressant 
      effect of L. helveticus NS8 in rats subjected to chronic restraint stress 
      depression and that this effect could be due to the microbiota-gut-brain axis. 
      They also suggest the therapeutic potential of L. helveticus NS8 in 
      stress-related and possibly other kinds of depression.
CI  - Copyright (c) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Liang, S
AU  - Liang S
AD  - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Wang, T
AU  - Wang T
AD  - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China.
FAU - Hu, X
AU  - Hu X
AD  - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China.
FAU - Luo, J
AU  - Luo J
AD  - Teacher Education College, Sichuan Normal University, Chengdu, China.
FAU - Li, W
AU  - Li W
AD  - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Wu, X
AU  - Wu X
AD  - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Duan, Y
AU  - Duan Y
AD  - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China.
FAU - Jin, F
AU  - Jin F
AD  - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150925
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0DHU5B8D6V (Citalopram)
RN  - 130068-27-8 (Interleukin-10)
RN  - 333DO1RDJY (Serotonin)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - VTD58H1Z2X (Dopamine)
RN  - W980KJ009P (Corticosterone)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Anxiety/etiology/metabolism/*prevention & control
MH  - *Behavior, Animal/drug effects
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Citalopram/pharmacology
MH  - Corticosterone/blood
MH  - Depression/etiology/metabolism/*prevention & control
MH  - Dopamine/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Interferon-gamma/blood
MH  - Interleukin-10/blood
MH  - *Lactobacillus helveticus
MH  - Male
MH  - Norepinephrine/metabolism
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - Probiotics/*administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Restraint, Physical
MH  - Serotonin/metabolism
MH  - Selective Serotonin Reuptake Inhibitors/pharmacology
MH  - Stress, Psychological/*complications
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - BDNF
OT  - Lactobacillus helveticus
OT  - chronic restraint stress
OT  - depression
OT  - microbiota-gut-brain axis
OT  - serotonin
EDAT- 2015/09/27 06:00
MHDA- 2016/08/16 06:00
CRDT- 2015/09/27 06:00
PHST- 2015/02/24 00:00 [received]
PHST- 2015/09/11 00:00 [revised]
PHST- 2015/09/11 00:00 [accepted]
PHST- 2015/09/27 06:00 [entrez]
PHST- 2015/09/27 06:00 [pubmed]
PHST- 2016/08/16 06:00 [medline]
AID - S0306-4522(15)00852-0 [pii]
AID - 10.1016/j.neuroscience.2015.09.033 [doi]
PST - ppublish
SO  - Neuroscience. 2015 Dec 3;310:561-77. doi: 10.1016/j.neuroscience.2015.09.033. 
      Epub 2015 Sep 25.