PMID- 26409118
OWN - NLM
STAT- MEDLINE
DCOM- 20160822
LR  - 20240109
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 118
DP  - 2015 Sep
TI  - Exposure to sub-chronic unpredictable stress accounts for antidepressant-like 
      effects in hamsters treated with BDNF and CNQX.
PG  - 65-77
LID - S0361-9230(15)30035-6 [pii]
LID - 10.1016/j.brainresbull.2015.09.007 [doi]
AB  - Recent evidences indicate that cerebral neurotrophic factors like vascular 
      endothelial growth factor plus signaling pathways of the glutamatergic 
      neuroreceptor system (L-Glu) are determinant modulators of depression-like 
      states. In the present study, the type of interaction(s) exerted by the AMPAergic 
      antagonist, 6-cyano-7-nitroquinoxalin-2,3-dione (CNQX) and the brain derived 
      neurotrophic factor (BDNF) on depression-like behaviors in hamsters (Mesocricetus 
      auratus) were investigated. Sub-chronic administration of BDNF in the hippocampal 
      dentate gyrus (DG) of stressed hamsters was responsible for very evident 
      (p<0.001) sucrose consumption along with notably elevated swimming bouts and 
      reduced immobility states in the forced swim test (FST). Meanwhile, CNQX 
      displayed evident anxiolytic actions in the elevated plus maze (EPM) as shown by 
      marked (p<0.01) increases of movements to and from both arms. Interestingly 
      cerebral neurodegeneration events, which are viewed during depression states, 
      were reduced following treatment with both compounds. Contextually, marked mRNA 
      expression levels of the BDNF receptor (tropomyosin-related kinase B; TrkB) were 
      detected in DG and the oriens-pyramidalis of HIP (Or-Py) while a moderate 
      (p<0.05) up-regulation was registered in the amygdalar central nucleus (CeA) and 
      the hypothalamic ventromedial nucleus (VMH) of hamsters treated with BDNF. 
      Similarly, this treatment caused moderate increases of the major stress protein 
      (Hsp70) in DG and Or-Py. Conversely, while CNQX induced similar TrkB expression 
      levels, it instead accounted for a moderate reduction of Hsp70 mRNAs in the same 
      brain areas. Overall these results support crucial roles played by BDNF and 
      AMPAergic neurosignaling mechanisms during distinct adaptive responses of 
      depression- and anxiety-like states in hamsters.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Alo, Raffaella
AU  - Alo R
AD  - Comparative Neuroanatomy Laboratory, Biology, Ecology & Earth Science Department 
      (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, 87030 Arcavacata di 
      Rende, Cosenza, Italy. Electronic address: raffaella.alo@unical.it.
FAU - Mele, Maria
AU  - Mele M
AD  - Comparative Neuroanatomy Laboratory, Biology, Ecology & Earth Science Department 
      (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, 87030 Arcavacata di 
      Rende, Cosenza, Italy.
FAU - Fazzari, Gilda
AU  - Fazzari G
AD  - Comparative Neuroanatomy Laboratory, Biology, Ecology & Earth Science Department 
      (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, 87030 Arcavacata di 
      Rende, Cosenza, Italy.
FAU - Avolio, Ennio
AU  - Avolio E
AD  - Comparative Neuroanatomy Laboratory, Biology, Ecology & Earth Science Department 
      (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, 87030 Arcavacata di 
      Rende, Cosenza, Italy; Health Center srl, Biomedical and Nutritional Center, via 
      Sabotino 66, 87100 Cosenza, Italy.
FAU - Canonaco, Marcello
AU  - Canonaco M
AD  - Comparative Neuroanatomy Laboratory, Biology, Ecology & Earth Science Department 
      (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, 87030 Arcavacata di 
      Rende, Cosenza, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150925
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/*pharmacology
MH  - Animals
MH  - Anti-Anxiety Agents/pharmacology
MH  - Antidepressive Agents/*pharmacology
MH  - Anxiety/metabolism
MH  - Brain/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cricetinae
MH  - Depression/*metabolism
MH  - HSP70 Heat-Shock Proteins/biosynthesis
MH  - Male
MH  - Maze Learning/drug effects
MH  - Mesocricetus
MH  - Receptor, trkB/biosynthesis
MH  - Stress, Psychological/*metabolism
OTO - NOTNLM
OT  - BDNF
OT  - CNQX
OT  - Hippocampus
OT  - Hsp70
OT  - Sub-chronic unpredictable stress
EDAT- 2015/09/27 06:00
MHDA- 2016/08/23 06:00
CRDT- 2015/09/27 06:00
PHST- 2015/07/01 00:00 [received]
PHST- 2015/09/17 00:00 [revised]
PHST- 2015/09/21 00:00 [accepted]
PHST- 2015/09/27 06:00 [entrez]
PHST- 2015/09/27 06:00 [pubmed]
PHST- 2016/08/23 06:00 [medline]
AID - S0361-9230(15)30035-6 [pii]
AID - 10.1016/j.brainresbull.2015.09.007 [doi]
PST - ppublish
SO  - Brain Res Bull. 2015 Sep;118:65-77. doi: 10.1016/j.brainresbull.2015.09.007. Epub 
      2015 Sep 25.