PMID- 26409150
OWN - NLM
STAT- MEDLINE
DCOM- 20160511
LR  - 20220321
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 105
IP  - 1
DP  - 2016 Jan
TI  - Assessing brain-derived neurotrophic factor as a novel clinical marker of 
      endometriosis.
PG  - 119-28.e1-5
LID - S0015-0282(15)01889-0 [pii]
LID - 10.1016/j.fertnstert.2015.09.003 [doi]
AB  - OBJECTIVE: To evaluate novel clinical markers of endometriosis including the 
      neurotrophins brain-derived neurotrophic factor (BDNF), nerve growth factor 
      (NGF), and neurotrophin 4/5 (NT4/5) and compare them to others previously 
      reported in the literature including cancer antigen 125 (CA-125) and C-reactive 
      protein (CRP). DESIGN: Prospective study. SETTING: University hospital. 
      PATIENT(S): One hundred thirty-eight women were prospectively and consecutively 
      recruited (April 2011-April 2015; cases: undergoing endometriosis surgery, n = 
      96; controls: benign gynecological surgery, n = 24 combined with healthy women, 
      no history of pelvic pain, not undergoing surgery, n = 18). INTERVENTION(S): 
      Collection of peripheral blood, gynecological and demographic information, 
      eutopic biopsy in women undergoing laparoscopy. MAIN OUTCOME MEASURE(S): 
      Circulating BDNF, NGF, NT4/5, CA-125, and CRP were quantified by ELISA. 
      RESULT(S): Plasma concentrations of BDNF were significantly greater in women with 
      endometriosis (1,091.9 pg/mL [640.4-1,683.1]; n = 68, untreated) than in controls 
      (731.4 pg/mL [352.1-1,176.2]; n = 36), whereas circulating NGF, NT4/5, CA-125, 
      and CRP were not different. When assessed for their ability to differentiate 
      between women with revised Classification of the American Society of Reproductive 
      Medicine stage 1 and 2 or stage 3 and 4 disease and controls, BDNF was the only 
      putative marker able to identify stage 1 and 2 disease, with a sensitivity and 
      specificity of 91.7% and 69.4%, respectively, using an arbitrary cutoff value of 
      1,000 pg/mL. We also demonstrated that circulating BDNF in women with 
      endometriosis who were receiving ovarian suppression for disease was equivalent 
      to that in the control group. This suggests that BDNF may also offer the 
      opportunity to monitor patient response to treatment. CONCLUSION(S): Plasma BDNF 
      is a potentially useful clinical marker of endometriosis that is superior to NGF, 
      NT4/5, CA-125, and CRP.
CI  - Copyright (c) 2016 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Wessels, Jocelyn M
AU  - Wessels JM
AD  - Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, 
      Canada.
FAU - Kay, Vanessa R
AU  - Kay VR
AD  - Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, 
      Canada.
FAU - Leyland, Nicholas A
AU  - Leyland NA
AD  - Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, 
      Canada.
FAU - Agarwal, Sanjay K
AU  - Agarwal SK
AD  - Department of Reproductive Medicine, University of California, San Diego, La 
      Jolla, California.
FAU - Foster, Warren G
AU  - Foster WG
AD  - Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, 
      Canada. Electronic address: fosterw@mcmaster.ca.
LA  - eng
GR  - MOP142230/Canadian Institutes of Health Research/Canada
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150925
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Endometriosis/*blood/*diagnosis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Up-Regulation
MH  - Young Adult
OTO - NOTNLM
OT  - Biomarker
OT  - C-reactive protein
OT  - CA-125
OT  - endometriosis
OT  - neurotrophin
EDAT- 2015/09/27 06:00
MHDA- 2016/05/12 06:00
CRDT- 2015/09/27 06:00
PHST- 2015/06/15 00:00 [received]
PHST- 2015/09/01 00:00 [revised]
PHST- 2015/09/02 00:00 [accepted]
PHST- 2015/09/27 06:00 [entrez]
PHST- 2015/09/27 06:00 [pubmed]
PHST- 2016/05/12 06:00 [medline]
AID - S0015-0282(15)01889-0 [pii]
AID - 10.1016/j.fertnstert.2015.09.003 [doi]
PST - ppublish
SO  - Fertil Steril. 2016 Jan;105(1):119-28.e1-5. doi: 
      10.1016/j.fertnstert.2015.09.003. Epub 2015 Sep 25.