PMID- 26410307
OWN - NLM
STAT- MEDLINE
DCOM- 20160815
LR  - 20181113
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 36
IP  - 12
DP  - 2015 Dec
TI  - Brain-derived neurotrophic factor and TrkB expression in the "oldest-old," the 
      90+ Study: correlation with cognitive status and levels of soluble amyloid-beta.
PG  - 3130-3139
LID - S0197-4580(15)00439-X [pii]
LID - 10.1016/j.neurobiolaging.2015.08.022 [doi]
AB  - Factors associated with maintaining good cognition into old age are unclear. 
      Decreased brain-derived neurotrophic factor (BDNF) contributes to memory loss in 
      Alzheimer's disease (AD), and soluble assemblies of amyloid-beta (Abeta) and tau 
      contribute to neurodegeneration. However, it is unknown whether AD-type 
      neuropathology, soluble Abeta and tau, or levels of BDNF and its receptor 
      tropomyosin-related kinase B (TrkB) correlate with dementia in the oldest-old. We 
      examined these targets in postmortem Brodmann's areas 7 and 9 (BA7 and BA9) in 4 
      groups of subjects >90 years old: (1) no dementia/no AD pathology, (2) no 
      dementia/AD pathology, (3) dementia/no AD pathology, (4) dementia/AD pathology. 
      In BA7, BDNF messenger RNA correlated with Mini-Mental State Examination scores 
      and was decreased in demented versus nondemented subjects, regardless of 
      pathology. Soluble Abeta42 was increased in both groups with AD pathology, demented 
      or not, compared to no dementia/no AD pathology subjects. Groups did not differ 
      in TrkB isoform levels or in levels of total soluble tau, individual tau 
      isoforms, threonine-181 tau phosphorylation, or ratio of phosphorylated 3R-4R 
      isoforms. In BA9, soluble Abeta42 correlated with Mini-Mental State Examination 
      scores and with BDNF messenger RNA expression. Thus, soluble Abeta42 and BDNF, but 
      not TrkB or soluble tau, correlate with dementia in the oldest-old.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Michalski, Bernadeta
AU  - Michalski B
AD  - Department of Psychiatry and Behavioural Neurosciences, McMaster University, 
      Hamilton, Ontario, Canada.
FAU - Corrada, Maria M
AU  - Corrada MM
AD  - Department of Epidemiology, University of California, Irvine, CA, USA; Institute 
      for Memory Impairments and Neurological Disorders, University of California, 
      Irvine, CA, USA.
FAU - Kawas, Claudia H
AU  - Kawas CH
AD  - Institute for Memory Impairments and Neurological Disorders, University of 
      California, Irvine, CA, USA.
FAU - Fahnestock, Margaret
AU  - Fahnestock M
AD  - Department of Psychiatry and Behavioural Neurosciences, McMaster University, 
      Hamilton, Ontario, Canada. Electronic address: fahnest@mcmaster.ca.
LA  - eng
GR  - R01 AG021055/AG/NIA NIH HHS/United States
GR  - R01 AG042444/AG/NIA NIH HHS/United States
GR  - P50 AG16573/AG/NIA NIH HHS/United States
GR  - P50 AG016573/AG/NIA NIH HHS/United States
GR  - MOP-102723/Canadian Institutes of Health Research/Canada
GR  - R01 AG21055/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150829
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
RN  - 0 (amyloid beta-protein (1-42))
RN  - 0 (tau Proteins)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (tropomyosin-related kinase-B, human)
SB  - IM
MH  - Aged, 80 and over
MH  - Aging
MH  - Amyloid beta-Peptides/genetics/metabolism
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cognition/*physiology
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/genetics/*metabolism
MH  - Neuropsychological Tests
MH  - Peptide Fragments/genetics/metabolism
MH  - Phosphorylation
MH  - Protein Isoforms
MH  - Protein-Tyrosine Kinases/genetics/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Receptor, trkB
MH  - tau Proteins/metabolism
PMC - PMC4756909
MID - NIHMS725845
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Amyloid-beta
OT  - BDNF
OT  - Human postmortem
OT  - Tau
OT  - TrkB
EDAT- 2015/09/28 06:00
MHDA- 2016/08/16 06:00
PMCR- 2016/12/01
CRDT- 2015/09/28 06:00
PHST- 2015/03/31 00:00 [received]
PHST- 2015/08/24 00:00 [revised]
PHST- 2015/08/25 00:00 [accepted]
PHST- 2015/09/28 06:00 [entrez]
PHST- 2015/09/28 06:00 [pubmed]
PHST- 2016/08/16 06:00 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - S0197-4580(15)00439-X [pii]
AID - 10.1016/j.neurobiolaging.2015.08.022 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2015 Dec;36(12):3130-3139. doi: 
      10.1016/j.neurobiolaging.2015.08.022. Epub 2015 Aug 29.