PMID- 26412071
OWN - NLM
STAT- MEDLINE
DCOM- 20160809
LR  - 20240325
IS  - 1875-6190 (Electronic)
IS  - 1570-159X (Print)
IS  - 1570-159X (Linking)
VI  - 13
IP  - 4
DP  - 2015
TI  - Research on the Pathological Mechanism and Drug Treatment Mechanism of 
      Depression.
PG  - 514-23
AB  - Depression is one of the prevalent and persistent psychiatric illnesses. It 
      brings heavy socioeconomic burden such as healthcare expenditures and even higher 
      suicide rates. Despite many hypotheses about its mechanism have been put forward, 
      so far it is still unclear, not to mention the precise and effective diagnostic 
      or therapeutic methods. In this paper, the current conditions of pathological and 
      pharmacological mechanism of depression were reviewed systematically. Firstly, 
      the most recent hypotheses and metabolomics based research including hereditary, 
      neurotransmitter systems, brain derived neurotrophic factor (BDNF), hyperactivity 
      of the hypothalamic pituitary adrenal (HPA) axis and inflammatory as well as 
      metabolomics were summarized. Secondly, the present situation and development on 
      antidepressant drugs at home and abroad were reviewed. Finally, a conclusion and 
      prospect on the pathological and pharmacological mechanism of depression were 
      provided primarily.
FAU - Peng, Guo-jiang
AU  - Peng GJ
FAU - Tian, Jun-sheng
AU  - Tian JS
FAU - Gao, Xiao-xia
AU  - Gao XX
FAU - Zhou, Yu-zhi
AU  - Zhou YZ
FAU - Qin, Xue-mei
AU  - Qin XM
AD  - Modern Research Center for Traditional Chinese Medicine of Shanxi University, 
      Taiyuan 030006, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Neuropharmacol
JT  - Current neuropharmacology
JID - 101157239
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Depression/*drug therapy/pathology
MH  - Depressive Disorder/*drug therapy
MH  - Humans
MH  - Hypothalamo-Hypophyseal System/*drug effects
MH  - Pituitary-Adrenal System/*drug effects
MH  - Research/trends
PMC - PMC4790409
EDAT- 2015/09/29 06:00
MHDA- 2016/08/10 06:00
PMCR- 2016/01/01
CRDT- 2015/09/29 06:00
PHST- 2015/09/29 06:00 [entrez]
PHST- 2015/09/29 06:00 [pubmed]
PHST- 2016/08/10 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - CN-EPUB-69988 [pii]
AID - CN-13-514 [pii]
AID - 10.2174/1570159x1304150831120428 [doi]
PST - ppublish
SO  - Curr Neuropharmacol. 2015;13(4):514-23. doi: 10.2174/1570159x1304150831120428.