PMID- 26412543
OWN - NLM
STAT- MEDLINE
DCOM- 20160519
LR  - 20181202
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 102
DP  - 2015 Oct
TI  - Expression of NGF, BDNF and their receptors in subcutaneous adipose tissue of 
      lactating cows.
PG  - 196-9
LID - S0034-5288(15)30046-1 [pii]
LID - 10.1016/j.rvsc.2015.08.016 [doi]
AB  - Currently, there are no reports of neurotrophins in adipose tissue of cows. The 
      distribution of nerve growth factor (NGF), brain-derived neurotrophic factor 
      (BDNF) and their high-affinity tyrosine kinase receptors TrkA and TrkB, was 
      investigated by immunohistochemical method in the subcutaneous adipose tissue of 
      cow at mid-lactation. Results revealed the localization of NGF and BDNF along the 
      plasma membrane and cytoplasm of adipocytes. Neurotrophin receptors TrkA and TrkB 
      showed moderate and strong positive staining in adipocytes, respectively. The 
      expression of NGF, BDNF, TRKB--but not of TRKA--was also confirmed at 
      transcriptional level by RT-PCR analyses. Considering the involvement of BDNF on 
      fat metabolism and of NGF on activation of the sympathetic response in human and 
      rodents, these neurotrophins could be related to lipogenesis and lipolysis 
      occurring during lactation in cows. The local production of these neurotrophins 
      supports their potential paracrine function for the regulation of adipocyte 
      activity and deserve further investigations.
CI  - Copyright (c) 2015. Published by Elsevier Ltd.
FAU - Colitti, Monica
AU  - Colitti M
AD  - Department of Agricultural and Environmental Sciences, University of Udine, via 
      delle Scienze, 206, 33100 Udine, Italy. Electronic address: 
      monica.colitti@uniud.it.
FAU - Loor, Juan J
AU  - Loor JJ
AD  - Department of Animal Sciences and Division of Nutritional Sciences, University of 
      Illinois Urbana, United States.
FAU - Stefanon, Bruno
AU  - Stefanon B
AD  - Department of Agricultural and Environmental Sciences, University of Udine, via 
      delle Scienze, 206, 33100 Udine, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150829
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Cattle/*genetics/metabolism
MH  - Female
MH  - *Gene Expression
MH  - Lactation
MH  - Nerve Growth Factors/*genetics/metabolism
MH  - Receptors, Nerve Growth Factor/*genetics/metabolism
MH  - Subcutaneous Fat/metabolism
OTO - NOTNLM
OT  - Adipose tissue
OT  - BDNF
OT  - Cow
OT  - Expression
OT  - NGF
OT  - Receptors
EDAT- 2015/09/29 06:00
MHDA- 2016/05/20 06:00
CRDT- 2015/09/29 06:00
PHST- 2015/07/03 00:00 [received]
PHST- 2015/08/18 00:00 [revised]
PHST- 2015/08/25 00:00 [accepted]
PHST- 2015/09/29 06:00 [entrez]
PHST- 2015/09/29 06:00 [pubmed]
PHST- 2016/05/20 06:00 [medline]
AID - S0034-5288(15)30046-1 [pii]
AID - 10.1016/j.rvsc.2015.08.016 [doi]
PST - ppublish
SO  - Res Vet Sci. 2015 Oct;102:196-9. doi: 10.1016/j.rvsc.2015.08.016. Epub 2015 Aug 
      29.