PMID- 26413108
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150928
LR  - 20200930
IS  - 1738-5520 (Print)
IS  - 1738-5555 (Electronic)
IS  - 1738-5520 (Linking)
VI  - 45
IP  - 5
DP  - 2015 Sep
TI  - Relationship between Right Ventricular Longitudinal Strain, Invasive 
      Hemodynamics, and Functional Assessment in Pulmonary Arterial Hypertension.
PG  - 398-407
LID - 10.4070/kcj.2015.45.5.398 [doi]
AB  - BACKGROUND AND OBJECTIVES: Right ventricular longitudinal strain (RVLS) is a new 
      parameter of RV function. We evaluated the relationship of RVLS by 
      speckle-tracking echocardiography with functional and invasive parameters in 
      pulmonary arterial hypertension (PAH) patients. SUBJECTS AND METHODS: Thirty four 
      patients with World Health Organization group 1 PAH (29 females, mean age 45+/-13 
      years old). RVLS were analyzed with velocity vector imaging. RESULTS: Patients 
      with advanced symptoms New York Heart Association (NYHA) functional class 
      III/IV had impaired RVLS in global RV (RVLSglobal, -17+/-5 vs. -12+/-3%, p<0.01) and 
      RV free wall (RVLSFW, -19+/-5 vs. -14+/-4%, p<0.01 to NYHA class I/II). Baseline 
      RVLSglobal and RVLSFW showed significant correlation with 6-minute walking 
      distance (r=-0.54 and r=-0.57, p<0.01 respectively) and logarithmic 
      transformation of brain natriuretic peptide concentration (r=0.65 and r=0.65, 
      p<0.01, respectively). These revealed significant correlations with cardiac index 
      (r=-0.50 and r=-0.47, p<0.01, respectively) and pulmonary vascular resistance 
      (PVR, r=0.45 and r=0.45, p=0.01, respectively). During a median follow-up of 33 
      months, 25 patients (74%) had follow-up examinations. Mean pulmonary arterial 
      pressure (mPAP, 54+/-13 to 46+/-16 mmHg, p=0.03) and PVR (11+/-5 to 6+/-2 wood units, 
      p<0.01) were significantly decreased with pulmonary vasodilator treatment. 
      RVLSglobal (-12+/-5 to -16+/-5%, p<0.01) and RVLSFW (-14+/-5 to -18+/-5%, p<0.01) were 
      significantly improved. The decrease of mPAP was significantly correlated with 
      improvement of RVLSglobal (r=0.45, p<0.01) and RVLSFW (r=0.43, p<0.01). The PVR 
      change demonstrated significant correlation with improvement of RVLSglobal 
      (r=0.40, p<0.01). CONCLUSION: RVLS correlates with functional and invasive 
      hemodynamic parameters in PAH patients. Decrease of mPAP and PVR as a result of 
      treatment was associated with improvement of RVLS.
FAU - Park, Jae-Hyeong
AU  - Park JH
AD  - Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland 
      Clinic, Cleveland, Ohio, USA. ; Cardiology Division of Internal Medicine, 
      Chungnam National University, Chungnam National University Hospital, Daejeon, 
      Korea.
FAU - Kusunose, Kenya
AU  - Kusunose K
AD  - Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland 
      Clinic, Cleveland, Ohio, USA. ; Department of Cardiovascular Medicine, Tokushima 
      University Hospital, Tokushima, Japan.
FAU - Kwon, Deborah H
AU  - Kwon DH
AD  - Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland 
      Clinic, Cleveland, Ohio, USA.
FAU - Park, Margaret M
AU  - Park MM
AD  - Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland 
      Clinic, Cleveland, Ohio, USA. ; Department of Pathobiology, Lerner Research 
      Institute, Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Erzurum, Serpil C
AU  - Erzurum SC
AD  - Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 
      Cleveland, Ohio, USA. ; Pulmonary and Critical Care Medicine, Respiratory 
      Institute, Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Thomas, James D
AU  - Thomas JD
AD  - Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland 
      Clinic, Cleveland, Ohio, USA.
FAU - Grimm, Richard A
AU  - Grimm RA
AD  - Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland 
      Clinic, Cleveland, Ohio, USA.
FAU - Griffin, Brian P
AU  - Griffin BP
AD  - Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland 
      Clinic, Cleveland, Ohio, USA.
FAU - Marwick, Thomas H
AU  - Marwick TH
AD  - Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland 
      Clinic, Cleveland, Ohio, USA. ; Menzies Research Institute, Tasmania, Australia.
FAU - Popovic, Zoran B
AU  - Popovic ZB
AD  - Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland 
      Clinic, Cleveland, Ohio, USA.
LA  - eng
PT  - Journal Article
DEP - 20150422
PL  - Korea (South)
TA  - Korean Circ J
JT  - Korean circulation journal
JID - 101247141
EIN - Korean Circ J. 2016 Mar;46(2):273. PMID: 27014362
PMC - PMC4580699
OTO - NOTNLM
OT  - Familial primary pulmonary hypertension
OT  - Heart ventricles
OT  - Ventricular function, right
COIS- The authors have no financial conflicts of interest.
EDAT- 2015/09/29 06:00
MHDA- 2015/09/29 06:01
PMCR- 2015/09/01
CRDT- 2015/09/29 06:00
PHST- 2015/02/16 00:00 [received]
PHST- 2015/03/15 00:00 [revised]
PHST- 2015/04/17 00:00 [accepted]
PHST- 2015/09/29 06:00 [entrez]
PHST- 2015/09/29 06:00 [pubmed]
PHST- 2015/09/29 06:01 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - 10.4070/kcj.2015.45.5.398 [doi]
PST - ppublish
SO  - Korean Circ J. 2015 Sep;45(5):398-407. doi: 10.4070/kcj.2015.45.5.398. Epub 2015 
      Apr 22.