PMID- 26413621
OWN - NLM
STAT- MEDLINE
DCOM- 20151130
LR  - 20190715
IS  - 1533-4880 (Print)
IS  - 1533-4880 (Linking)
VI  - 15
IP  - 3
DP  - 2015 Mar
TI  - Inhibition of Viability of the Respiratory Epithelial Cells Using Functionalized 
      Graphene Oxide.
PG  - 2060-6
AB  - The viability of A549 cells, a human lung carcinoma epithelial cell line, was 
      evaluated after exposure to graphene oxide (GO) and its derivatives (dodecylamine 
      GO (DA-GO), reduced GO (rGO), and sodium dodecyl sulfate rGO (SDS-rGO)). A 
      decrease in the relative amounts of C-OH bonds and an increase in the number of 
      C-C and C-N bonds in the C 1s spectra indicated that the reduction of GO to rGO 
      and the surface functionalization of GO has taken place. The appearance of amine 
      stretching bands, out-of-plane C-H stretching vibrations, and S = O stretching 
      bands in the infrared spectra indicated the formation of DA-GO, rGO, and SDS-rGO, 
      respectively. Low concentrations (3-25 microg/mL) of GO, rGO, and SDS-rGO were found 
      to be mildly toxic, whereas DA-GO exhibited severe dose-dependent toxicity over 
      the same concentration range. High concen- trations (50-400 microg/mL) of GO and all 
      its derivatives resulted in severe toxicity to the A549 cells. It is believed 
      that surface functionality strongly affects the viability of A549 cells.
FAU - Park, Chang Seok
AU  - Park CS
FAU - Choi, Kyoung Soon
AU  - Choi KS
FAU - Shin, Jong Wook
AU  - Shin JW
FAU - Kim, Soo Young
AU  - Kim SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nanosci Nanotechnol
JT  - Journal of nanoscience and nanotechnology
JID - 101088195
RN  - 0 (Amines)
RN  - 0 (Oxides)
RN  - 368GB5141J (Sodium Dodecyl Sulfate)
RN  - 7782-42-5 (Graphite)
RN  - YWY9OD6A2K (dodecylamine)
SB  - IM
MH  - Amines/chemistry
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Epithelial Cells/*cytology/*drug effects
MH  - Graphite/*adverse effects/*chemistry
MH  - Humans
MH  - Lung/*pathology
MH  - Models, Molecular
MH  - Molecular Conformation
MH  - Oxidation-Reduction
MH  - Oxides/*chemistry
MH  - Sodium Dodecyl Sulfate/chemistry
MH  - Surface Properties
EDAT- 2015/09/29 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/09/29 06:00
PHST- 2015/09/29 06:00 [entrez]
PHST- 2015/09/29 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1166/jnn.2015.9539 [doi]
PST - ppublish
SO  - J Nanosci Nanotechnol. 2015 Mar;15(3):2060-6. doi: 10.1166/jnn.2015.9539.